Zobrazeno 1 - 10
of 221
pro vyhledávání: '"GEORGE L. KENYON"'
Autor:
Gregory A. Petsko, Michael J. McLeish, Anand Balakrishnan, Alejandra Yep, Frank Jordan, Sumit Chakraborty, Gabriel S. Brandt, Natalia Nemeria, Malea M. Kneen, Dagmar Ringe, George L. Kenyon
Publikováno v:
Biochemistry. 48:981-994
The mechanism of the enzyme benzoylformate decarboxylase (BFDC), which carries out a typical thiamin diphosphate (ThDP)-dependent nonoxidative decarboxylation reaction, was studied with the chromophoric alternate substrate (E)-2-oxo-4(pyridin-3-yl)-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be4a7c4ebd865eef7daebff5fcead52
https://doi.org/10.1021/bi801810h
https://doi.org/10.1021/bi801810h
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1784:1248-1255
The mandelate pathway of Pseudomonas putida ATCC 12633 comprises five enzymes and catalyzes the conversion of R - and S -mandelamide to benzoic acid which subsequently enters the β-ketoadipate pathway. Although the first four enzymes have been exten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91999a84c85fc516e7c90a7850e83b81
https://doi.org/10.1016/j.bbapap.2008.04.015
https://doi.org/10.1016/j.bbapap.2008.04.015
Autor:
Alejandra Yep, Gabriel S. Brandt, Michael J. McLeish, Natalia Nemeria, George L. Kenyon, Sumit Chakraborty, Frank Jordan, Dagmar Ringe, Gregory A. Petsko
Publikováno v:
Biochemistry. 47:7734-7743
Benzaldehyde lyase (BAL) catalyzes the reversible cleavage of ( R)-benzoin to benzaldehyde utilizing thiamin diphosphate and Mg (2+) as cofactors. The enzyme is important for the chemoenzymatic synthesis of a wide range of compounds via its carboliga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad291b4beed54bf6bbb4f76a10048e07
https://doi.org/10.1021/bi8004413
https://doi.org/10.1021/bi8004413
Autor:
Michael J. McLeish, Natalia Nemeria, Alejandra Yep, Frank Jordan, Sumit Chakraborty, George L. Kenyon
Publikováno v:
Biochemistry. 47:3800-3809
Direct spectroscopic observation of thiamin diphosphate-bound intermediates was achieved on the enzyme benzaldehyde lyase, which carries out reversible and highly enantiospecific conversion of ( R)-benzoin to benzaldehyde. The key enamine intermediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf48c466e33cd0cf1a8dc170b04e503c
https://doi.org/10.1021/bi702302u
https://doi.org/10.1021/bi702302u
Autor:
Elisabeth Davioud-Charvet, Christine Nickel, Adriano D. Andricopulo, George L. Kenyon, R. Krogh, Michael J. McLeish, M. B. Akoachere, Arscott Ld, Katja Becker, Charles H. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2283-2292
Plasmodium falciparum thioredoxin reductase (PfTrxR: NADPH + Trx(S)2 + H+ ↔ NADP+ + Trx(SH)2) is a high Mr flavin-dependent TrxR that reduces thioredoxin (Trx) via a CysXXXXCys pair located penultimately to the C-terminal Gly. In this respect, PfTr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e2aa115f64e9ec2d2e3e6b5a1d8e0d
https://doi.org/10.1016/j.bmcl.2006.01.027
https://doi.org/10.1016/j.bmcl.2006.01.027
Autor:
Michael J. McLeish, George L. Kenyon
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 40:1-20
Found in all vertebrates, creatine kinase catalyzes the reversible reaction of creatine and ATP forming phosphocreatine and ADP. Phosphocreatine may be viewed as a reservoir of "high-energy phosphate" which is able to supply ATP, the primary energy s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ff532fcb25b208f974254e57df6351
https://doi.org/10.1080/10409230590918577
https://doi.org/10.1080/10409230590918577
Publikováno v:
Journal of Biological Chemistry. 279:38424-38432
2-Naphthalenesulfonic acid (4-hydroxy-7-[[[[5-hydroxy-6-[(4 cinnamylphenyl)azo]-7-sulfo-2-naphthalenyl]amino]-carbonyl]amino]-3-[(4-cinnamylphenyl)]azo (KM-1)) is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) that was designed to bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8738ea60be78a794cb2bd654c46bc58
https://doi.org/10.1074/jbc.m406241200
https://doi.org/10.1074/jbc.m406241200
Autor:
Michael J. McLeish, Eduard A. Sergienko, Elena S. Polovnikova, Miriam S. Hasson, Frank Jordan, Natalie L. Anderson, George L. Kenyon, Asim K. Bera, John T. Burgner
Publikováno v:
Biochemistry. 42:1820-1830
Benzoylformate decarboxylase is a member of the family of enzymes that are dependent on the cofactor thiamin diphosphate. A structure of this enzyme binding (R)-mandelate, a competitive inhibitor, suggests that at least two hydrogen bonds are formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff859a806d0517aa6678605b7539b732
https://doi.org/10.1021/bi026490k
https://doi.org/10.1021/bi026490k
Autor:
George L. Kenyon, Michael J. McLeish
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Selective inhibitors of enzyme-catalyzed reactions are widely used in both biochemical and medical science. The inhibitor may be used to block either a single enzyme or a metabolic pathway. The utility of an enzyme inhibitor as a mechanistic probe or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f028512bfeeb9f454f9ceca3fef491c
https://doi.org/10.1002/0471266949.bmc015
https://doi.org/10.1002/0471266949.bmc015
Autor:
Stephen H. Hughes, Dolan H. Eargle, Maxine V. Medaglia, Edward Arnold, Karl Maurer, Diana C. Roe, Robert W. Buckheit, Hong Qiang Gao, Robert J. Fisher, Angelika Muscate, A. Geoffrey Skillman, Elisabeth Davioud-Charvet, Paul L. Boyer, George L. Kenyon, Todd J. A. Ewing, Irwin D. Kuntz, Margaret J. Stauber
Publikováno v:
Bioorganic Chemistry. 30:443-458
The human immunodeficiency virus (HIV) epidemic is an important medical problem. Although combination drug regimens have produced dramatic decreases in viral load, current therapies do not provide a cure for HIV infection. We have used structure-base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46fa649ae10837191d892d139761bc8
https://doi.org/10.1016/s0045-2068(02)00502-3
https://doi.org/10.1016/s0045-2068(02)00502-3