Zobrazeno 1 - 10
of 288
pro vyhledávání: '"GEORGE J. CHRIST"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The rat hindlimb is a frequently utilized pre-clinical model system to evaluate injuries and pathologies impacting the hindlimbs. These studies have demonstrated the translational potential of this model but have typically focused on the for
Externí odkaz:
https://doaj.org/article/1514f88400b24c59b72412a402fa3809
Autor:
Jack A. Dienes, Xiao Hu, Kevin D. Janson, Conrad Slater, Emily A. Dooley, George J. Christ, Shawn D. Russell
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
There is currently a substantial volume of research underway to develop more effective approaches for the regeneration of functional muscle tissue as treatment for volumetric muscle loss (VML) injury, but few studies have evaluated the relationship b
Externí odkaz:
https://doaj.org/article/e99191c701e84414bb7b6370ad806d4e
Autor:
Christina L. Ross, Mevan Siriwardane, Graça Almeida-Porada, Christopher D. Porada, Peter Brink, George J. Christ, Benjamin S. Harrison
Publikováno v:
Stem Cell Research, Vol 15, Iss 1, Pp 96-108 (2015)
Human bone marrow stromal cells (hBMSCs, also known as bone marrow-derived mesenchymal stem cells) are a population of progenitor cells that contain a subset of skeletal stem cells (hSSCs), able to recreate cartilage, bone, stroma that supports hemat
Externí odkaz:
https://doaj.org/article/71190baa8f834938b7badbaaaaec0d5f
Autor:
Sarah E. Dyer, J. David Remer, Kelsey E. Hannifin, Aishwarya Hombal, Joseph C. Wenke, Thomas J. Walters, George J. Christ
Publikováno v:
J Appl Physiol (1985)
Extended tourniquet application, often associated with battlefield extremity trauma, can lead to severe ischemia-reperfusion (I/R) injury in skeletal muscle. Particulate oxygen generators (POGs) can be directly injected into tissue to supply oxygen t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a0344740bb66450e7c9584307de92e
https://pubmed.ncbi.nlm.nih.gov/34989649
https://pubmed.ncbi.nlm.nih.gov/34989649
Publikováno v:
Therapeutics and Clinical Risk Management
A need exists for local (ie, bladder-specific) interventions to treat overactive bladder (OAB) with low risk of unwanted postprocedural outcomes. Gene therapy targeted to leverage endogenous physiology in bladder cells may assist in restoring normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe457e85d35431079bb579c0b9b3135e
https://doi.org/10.2147/tcrm.s291798
https://doi.org/10.2147/tcrm.s291798
Adipose Stem Cells Enhance Nerve Regeneration and Muscle Function in a Peroneal Nerve Ablation Model
Autor:
Jacqueline M. Bliley, Andrew Portell, Juliana A. Passipieri, Kaushik P. Venkatesh, George J. Christ, Kacey G. Marra, Joshua Glazier, Joseph A. Frank, Jack Dienes, Damian Grybowski, Benjamin K. Schilling
Publikováno v:
Tissue Engineering Part A. 27:297-310
Severe peripheral nerve injuries have devastating consequences on the quality of life in affected patients, and they represent a significant unmet medical need. Destruction of nerve fibers results in denervation of targeted muscles, which, subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381213fa876238947d6fe351cd95f220
https://doi.org/10.1089/ten.tea.2018.0244
https://doi.org/10.1089/ten.tea.2018.0244
Publikováno v:
Biomaterials Science. 9:4040-4053
Skeletal muscle is characterized by its three-dimensional (3D) anisotropic architecture composed of highly aligned and electrically-excitable muscle fibers that enable normal movement. Biomaterial-based tissue engineering approaches to repair skeleta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b1ec6f72119095dd3dc396a6cae6ea
https://doi.org/10.1039/d1bm00147g
https://doi.org/10.1039/d1bm00147g
Publikováno v:
Journal of biomedical materials research. Part A. 110(10)
Skeletal muscle's combination of three-dimensional (3D) anisotropy and electrical excitability is critical for enabling normal movement. We previously developed a 3D aligned collagen scaffold incorporating conductive polypyrrole (PPy) particles to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ea6966416acd6b39da7259be02b9f4
https://pubmed.ncbi.nlm.nih.gov/35762455
https://pubmed.ncbi.nlm.nih.gov/35762455
Autor:
George J. Christ, Gregg M Gardner, Kathryn K. Smith, Ivan M Basurto, Audrey I. Hansrisuk, Austin R. Amacher, Steven R. Caliari, Juliana A. Passipieri
Publikováno v:
Tissue Eng Part A
Volumetric muscle loss (VML) injuries are characterized by permanent loss of muscle mass, structure, and function. Hydrogel biomaterials provide an attractive platform for skeletal muscle tissue engineering due to the ability to easily modulate their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c66faf2cdc8346a28536cbc3978640
https://europepmc.org/articles/PMC9057873/
https://europepmc.org/articles/PMC9057873/
Autor:
Emma C Afferton, Juliana A. Passipieri, Ellen L. Mintz, Victoria M Toscano, Isabelle R Franklin, Poonam Sharma, George J. Christ
Publikováno v:
Tissue Eng Part A
Volumetric muscle loss (VML) injuries, by definition, exceed the endogenous repair capacity of skeletal muscle resulting in permanent structural and functional deficits. VML injuries present a significant burden for both civilian and military medicin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfa1891db5d19429c207412583c5f68
https://doi.org/10.1089/ten.tea.2019.0126
https://doi.org/10.1089/ten.tea.2019.0126