Zobrazeno 1 - 10
of 124
pro vyhledávání: '"GEORG SCZAKIEL"'
Autor:
Josephine Dubois, Georg Sczakiel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Numerous indirect and in silico produced evidences suggest circular RNAs (circRNA) in mammals while thorough experimental proofs of their existence have rarely been reported. Biological studies of circRNA, however, should be based on experim
Externí odkaz:
https://doaj.org/article/99c3be04329a4556ac01ef5622f903d7
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0229193 (2020)
BACKGROUND:Urine-based diagnostics indicated involvement of oncoprotein 18 (OP18) in bladder cancer. In cell culture models we investigated the role of OP18 for malignant cell growth. METHODS:We analyzed 113 urine samples and investigated two human B
Externí odkaz:
https://doaj.org/article/5e8f92d75b8d47fb9919418bed71a8ce
Autor:
Clint L Miller, Ulrike Haas, Roxanne Diaz, Nicholas J Leeper, Ramendra K Kundu, Bhagat Patlolla, Themistocles L Assimes, Frank J Kaiser, Ljubica Perisic, Ulf Hedin, Lars Maegdefessel, Heribert Schunkert, Jeanette Erdmann, Thomas Quertermous, Georg Sczakiel
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004263 (2014)
Genome-wide association studies (GWAS) have identified chromosomal loci that affect risk of coronary heart disease (CHD) independent of classical risk factors. One such association signal has been identified at 6q23.2 in both Caucasians and East Asia
Externí odkaz:
https://doaj.org/article/110ec0e471a84977a6042ab7941be3e3
Autor:
Sonja Petkovic, Sarah Graff, Georg Sczakiel, Jasmin Dülfer, Vanessa-Patricia Ruppert, Julia Berghaus, Nina Feller
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Circular RNA is progressively reported to occur in various species including mammals where it is thought to be involved in the post-transcriptional regulation of gene expression, partly via interactions with microRNA. Here, we asked whether the circu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a3e8b32cb1222b641b483af9e714b6
https://doi.org/10.1080/15476286.2021.1978214
https://doi.org/10.1080/15476286.2021.1978214
Autor:
Georg Sczakiel, Bernhard Haubold, Josephine Dubois, Rosel Kretschmer-Kazemi Far, Jacqueline Rueger
Publikováno v:
Oncotarget
Non-invasive clinical diagnostics of bladder cancer is feasible via a set of chemically distinct molecules including macromolecular tumor markers such as polypeptides and nucleic acids. In terms of tumor-related aberrant gene expression, RNA transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42d603f347424b36aeddb8ee3a0c43f
https://doi.org/10.18632/oncotarget.27954
https://doi.org/10.18632/oncotarget.27954
Publikováno v:
Cancers
Cancers, Vol 13, Iss 4381, p 4381 (2021)
Volume 13
Issue 17
Cancers, Vol 13, Iss 4381, p 4381 (2021)
Volume 13
Issue 17
Simple Summary Non-invasive tumor diagnosis includes liquid biopsy withdrawn from extracellular and extratissue samples including human urine in which RNA-based markers can be measured by various means. RNA markers include short-chain RNA such as mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef64e81b733209fe87b041206622630
http://europepmc.org/articles/PMC8430584
http://europepmc.org/articles/PMC8430584
Autor:
Simon Dornseifer, Kirsten Frank, Georg Sczakiel, Janine Liebschwager, Sarah Willkomm, Jens Christian Claussen, Thomas Martinetz, Tobias Restle, Sandra D. Laufer, Foteini Beltsiou, Rosel Kretschmer-Kazemi Far
Publikováno v:
Nucleic Acids Research
The discovery of RNA interference (RNAi) gave rise to the development of new nucleic acid-based technologies as powerful investigational tools and potential therapeutics. Mechanistic key details of RNAi in humans need to be deciphered yet, before suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c1d2121ca59b6ca03450e9f84cf76a
https://doi.org/10.1093/nar/gkv1200
https://doi.org/10.1093/nar/gkv1200
Publikováno v:
RNA Biology
Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) or their target sites (miR-SNPs) within the 3'-UTR of mRNAs are increasingly thought to play a major role in pathological dysregulation of gene expression. Here, we studied the functional r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef6c6e06552b5b075d67841191abf4f
http://europepmc.org/articles/PMC3495750
http://europepmc.org/articles/PMC3495750
Autor:
Dmitri I. Svergun, Tobias Restle, Rajesh Ponnusamy, Weifeng Shang, Georg Sczakiel, Qingjun Ma, Rolf Hilgenfeld, Yibei Xiao
Publikováno v:
Journal of Virology; Vol 86
Journal of Virology
Journal of virology 86, 4444-4454 (2012). doi:10.1128/JVI.06635-11
Journal of Virology
Journal of virology 86, 4444-4454 (2012). doi:10.1128/JVI.06635-11
Nonstructural proteins 7 and 8 of severe acute respiratory syndrome coronavirus (SARS-CoV) have previously been shown by X-ray crystallography to form an 8:8 hexadecamer. In addition, it has been demonstrated that N-terminally His 6 -tagged SARS-CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444e909cf244241651c4f937c29f8359
Autor:
Alfred C. Feller, Georg Sczakiel, Dieter Jocham, Hartmut Merz, Jens M. Warnecke, Merle Hanke, Ingo Kausch, Kai P. Hoefig
Publikováno v:
Urologic Oncology: Seminars and Original Investigations. 28:655-661
Objectives MicroRNAs have been shown to be related to specific types of malignant cell growth. In case of urothelial bladder cancer (BCa), novel noninvasive diagnosis is particularly required and it is attractive to consider, as urine is an easily av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203e0d91fb6e301d90ea26599dc8c1f8
https://doi.org/10.1016/j.urolonc.2009.01.027
https://doi.org/10.1016/j.urolonc.2009.01.027