The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma

Autor: Thibault Houles, Jonathan Boucher, Genevieve Lavoie, Graham Macleod, Sichun Lin, Stephane Angers, Philippe P Roux

CDK12 is a transcriptional cyclin-dependent kinase (CDK) that interacts with cyclin K to regulate different aspects of gene expression. The CDK12-cyclin K complex phosphorylates several substrates, including RNA Pol II, and thereby regulates transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9430e2d713da5241b56eaf6fa7400845
https://doi.org/10.1101/2023.05.30.542844

Do offers of admission to regional medical campuses impact an applicant's decision to decline their acceptance to medical school?

Autor: Alysha, Roberts, Kavita, Raju, Thomas, Sebastian Haupt, Todd, Dow, Mike, Smyth, J Thomas, Toguri, Rosalind, Bihun, Margo, Mountjoy, Andrew, Costa, Graham, Campbell, Emily, Fong, Alex, Wong, Tibetha, Kemble, Stephanie, Chan, Nathasha, Dias, Amanda, Leslie, Maggie, McCann, Kristen, McFadyen, Olivia, Spohn, Janet, Vogt, Barry, Isaacs, Alvin, Loh, Fok-Han, Leung, Jeremy, Dick, Karen, Pinder, George T., Kitching, Adrina, Zhong, Orianna, Mak, Marissa, Ley, Farnaz, Javadian, Alexandra, Davidson, Rajiv, Shah, Anita, Shah, Lindsay, Shirreff, Eliane, Shore, David-Dan, Nguyen, Julie, de Meulemeester, Kacper, Niburski, Gordon, Best, Koray, Demir, Eric, Mitchell, James, Riggs, Rebecca, Barnfield, Trystan, Nault, Rajas, Tipnis, Leshawn, Benedict, Kevin, Si, Thomas, Haupt, Tom, Toguri, Anna, MacLeod, Alex, Sapa, Ahtsham, Niazi, Clyde, Matava, Tina (Shijie), Zhou, Lucie, Dupuis, Cheryl, Cytrynbaum, Roberto, Mendoza-Londono, Arielle, Brickman, Vincent, Wu, Boris, Zevin, Sylvie, Bowden, Shawn, Khan, Kimia, Sorouri, Stephanie, Searle, Lauren, Carr, Jory, Simpson, Farina, Rafiq, Babar, Haroon, Zhubo, Zhang, Avrilynn, Ding, Andrea, Winthrop, Eleni, Katsoulas, Natalie, Lidster, Caitlin, VanDeCappelle, Saroo, Sharma, Samuel, Wilson, Dalia, Karol, Christopher G., Elliott, Kuan-chin Jean, Chen, Sachin, Pasricha, Zsuzsanna, Keri, Matthew, Holden, Tamas, Ungi, Gabor, Fichtinger, Vijay, Sandhu, Raed, Hawa, Carla, Garcia, Andrea, Waddell, Sophie, Glanz, Rachel, McDonald, Lisa, Kachaniwsky, Sabrina, Kolker, Pearl, Yang, Karen, Fleming, Vincent, Ménard-Cholette, Élizabeth, Richard, Julie, Thériault, Emily, Wang, Frank, Battaglia, Emilie, Langlois, Marisa, Market, John, Shin, Christine, Seabrook, Tim, Brandys, Alexander, Cormier, Erin, Brennan, Evan, Mah, Megan, Deck, Julie, Yu, Kish, Lyster, Joann, Kawchuk, Brian, Brownbridge, Alison, Turnquist, Luke, Terrett, Brent, Thoma, Maria, Merlano, Céline, Sayed, Meghan, McConnell, Christopher, Ramnanan, Nikhil, Rastogi, Celine, Sayed, Michael, Elfassy, Laura, Duncan, Alison, Green, Katina, Tzanetos, Joyce, Nyhof-Young, Alexis, Fong-Leboeuf, Irina, Simin, Andy, Le, Debra, Andrews, Cynthia, Henriksen, Vincent, Jobin, Louise, Fugère, Flora, Jung, Mike, Wiley, Frazer, Howard, Nicholas, Sequeira, Sarah, Mavin, Gayle, Adams-Carpino, April, Kindrat, Katherina, Baranova, Jacqueline, Torti, Mark, Goldszmidt, Maichael, Thejoe, Carrie, Krekoski, Christie, Newton, Tom, MacMillan, Robert, Wu, Rodrigo, Cavalcanti, Mona, Maleki, Kelly, Huang, Heather, McEwen, Glenn, Regehr, Dhiren, Naidu, Tracey, Hillier, Tul-Zahra, Rida, Laura, Muldoon, Marie-Hélène, Chomienne, Karine, Toupin-April, Chloe, Thabet, Megan, Doherty, Tatiana, Fras, Meredith, McKague, Regina, Taylor-Gjevre, Michael, Prystajecky, Krista, Trinder, Fangyi, Liu, Yang, Qin, Imaan, Javeed, Vivian, Tia, Richard, Yu, John, Cameron, Dylan, Russelo, Danny, Kim, Alison, Bell, Michelle, Gibson, Yasamin, Mahjoub, Miranda, Wan, Marie, DeCock, Melanie, Lewis, Richard, Conn, Orla, Kearney, Michael, Shields, Mary, Tully, Tim, Dornan, Abirami, Kirubarajan, Tahmina, Shamsheri, Sangeeta, Mehta, Mélissa, Nepton-Riverin, Genevieve, Lavoie, Émilie, Courtois, Pascale, Ouellet- Dufour, Kaitlyn, Lam, Ben, Shachar, David, Rojas Gualdron, Hannah, Samuels, Vanessa, Rojas Luengas, Arman, Zereshkian, Paula, Veinot, Ashna, Bowry, Marcus, Law, Aashna, Duggal, Thomas, Jeffery, Dr., Joanne Rodger, Patrick, Von Hauff, Dr., Tracey Hillier, Anahita, Dehmoobad Sharifabadi, Asif, Doja, Chantalle, Clarkin, Akshay, Rajaram, Nimesh, Patel, Zachary, Hickey, Joseph, Newbigging, Brent, Wolfrom, Emily, Evans, Aselin, Weng, Brian, Tran, Victoria, Luong, Chris, Shields, Allison, Petrie, Katerina, Neumann, Andy, Grock, Anuja, Bhalerao, Teresa, Chan, Seth, Trueger, Natasha, Tang, Maria, Mylopoulus, Sanjeev, Sockalingam, Janaya E., Perron, Michael J., Coffey, Andrew, Lovell-Simons, Zheyu, Li, Seiya, Takeda, Luis, Dominguez, Chee Y., Ooi, Maxwell, Ng, Rohit, Malyala, He Tian, Chen, Katherine, Kuo, Alexander K., Ball, Michel P., Rathbone, Bruce, Wainman

Publikováno v: Canadian Medical Education Journal

Background/Purpose: Medical students face numerous stressors during their pre-clinical years, including developing confidence in their skills, knowledge and deciding which specialty to pursue. For those interested in specialties with limited integrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::45c3b2e735b6a1305b78f4eb5059b538
http://europepmc.org/articles/PMC6500504

Traces d'animaux du Québec : Guide d'identification

Autor: Mathieu Hébert, Geneviève Lavoie

Mathieu Hébert et Geneviève Lavoie, de l'école de survie Les Primitifs, t'aident à reconnaître les traces et les signes laissés par les animaux du Québec. De l'identification des espèces à l'interprétation des mouvements, été comme hiver

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Autor: Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P. Roux

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

The oncogene KRAS is frequently mutated in cancer, including colorectal cancer. Here, using a cell-surface proteomics approach, KRAS-mutated colorectal cancer cells are shown to express high levels of the copper transporter ATP7A, which has an essent

Externí odkaz: https://doaj.org/article/e0ea73c88dab4e7c804e408236956ef7

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit.

Autor: Emilie L Cerezo, Thibault Houles, Oriane Lié, Marie-Kerguelen Sarthou, Charlotte Audoynaud, Geneviève Lavoie, Maral Halladjian, Sylvain Cantaloube, Carine Froment, Odile Burlet-Schiltz, Yves Henry, Philippe P Roux, Anthony K Henras, Yves Romeo

Publikováno v: PLoS Genetics, Vol 17, Iss 6, p e1009583 (2021)

Ribosome biogenesis lies at the nexus of various signaling pathways coordinating protein synthesis with cell growth and proliferation. This process is regulated by well-described transcriptional mechanisms, but a growing body of evidence indicates th

Externí odkaz: https://doaj.org/article/d9e4b8bf8c4a485c8bce6800672ede2b