In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility

Autor: Michiyo Okamoto, Keiko Nakano, Azusa Takahashi-Nakaguchi, Kaname Sasamoto, Masashi Yamaguchi, Miguel Cacho Teixeira, Hiroji Chibana

Publikováno v: Journal of Fungi, Vol 9, Iss 2, p 240 (2023)

Mitochondrial dysfunction or morphological abnormalities in human pathogenic fungi are known to contribute to azole resistance; however, the underlying molecular mechanisms are unknown. In this study, we investigated the link between mitochondrial mo

Externí odkaz: https://doaj.org/article/dfc649e4cb3e4deb91035884946e46a7

CHARACTERIZING THE GROWTH ARREST SPECIFIC GENE, GEM1, IN CHICKEN EMBRYO FIBROBLASTS

Autor: Patel, Preyansh

Conditions that lead to reversible growth arrest (quiescence), promote the expression of a set of genes called growth arrest specific (GAS) genes. GAS genes play a crucial role in initiating and maintaining the entry into quiescence, while also activ

Externí odkaz: http://hdl.handle.net/11375/29417

A hunt for OM45 synthetic petite interactions in Saccharomyces cerevisiae reveals a role for Miro GTPase Gem1p in cristae structure maintenance

Autor: Shvetsova, A. (Antonina), Masud, A. J. (Ali J.), Schneider, L. (Laura), Bergmann, U. (Ulrich), Monteuuis, G. (Geoffray), Miinalainen, I. J. (Ilkka J.), Hiltunen, J. K. (J. Kalervo), Kastaniotis, A. J. (Alexander J.)

Om45 is a major protein of the yeast’s outer mitochondrial membrane under respiratory conditions. However, the cellular role of the protein has remained obscure. Previously, deletion mutant phenotypes have not been found, and clear amino acid seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::88fc8d9c0e1d126b44f24b668050b032
http://urn.fi/urn:nbn:fi-fe2022013111302

ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast

Autor: Andrew Murley, Laura L Lackner, Christof Osman, Matthew West, Gia K Voeltz, Peter Walter, Jodi Nunnari

Publikováno v: eLife, Vol 2 (2013)

Mitochondrial division is important for mitochondrial distribution and function. Recent data have demonstrated that ER–mitochondria contacts mark mitochondrial division sites, but the molecular basis and functions of these contacts are not understo

Externí odkaz: https://doaj.org/article/afcfbf8868544b1da1f95b827db1e1a3

Gem1 andERMESDo Not Directly Affect Phosphatidylserine Transport fromERto Mitochondria or Mitochondrial Inheritance

Autor: Dennis R. Voelker, Agnieszka Lewandowska, Tom A. Rapoport, Mesut Bilgin, Daniel F. Markgraf, Christer S. Ejsing, Janet M. Shaw, Mirco Junker, Tammy T. Nguyen, Jae-Yeon Choi

Publikováno v: Nguyen, T T, Lewandowska, A, Choi, J-Y, Markgraf, D F, Junker, M, Bilgin, M, Ejsing, C S, Voelker, D R, Rapoport, T A & Shaw, J M 2012, ' Gem1 and ERMES Do Not Directly Affect Phosphatidylserine Transport from ER to Mitochondria or Mitochondrial Inheritance ', Traffic, vol. 13, no. 6, pp. 880-90 . https://doi.org/10.1111/j.1600-0854.2012.01352.x
Traffic (Copenhagen, Denmark)

In yeast, a protein complex termed the ER-Mitochondria Encounter Structure (ERMES) tethers mitochondria to the endoplasmic reticulum. ERMES proteins are implicated in a variety of cellular functions including phospholipid synthesis, mitochondrial pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f3c0561d16c4edba02aa99923c70eb
https://doi.org/10.1111/j.1600-0854.2012.01352.x