Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5

Autor: Mo Wang, C. Chris Yun, Yiran Han, Lei Dong, Peijian He

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1073-1092 (2021)

Background & Aims Epithelial cells form a monolayer at mucosal surface that functions as a highly selective barrier. Lysophosphatidic acid (LPA) is a bioactive lipid that elicits a broad range of biological effects via cognate G protein-coupled recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76070d2010df41333ad81cb10e8a8f40
http://europepmc.org/articles/PMC8350072

Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma

Autor: Alexander Gont, Danny Jomaa, Karen Jardine, Ian A. J. Lorimer, Sylvie J. Lavictoire, David P. Cook

Publikováno v: The Journal of Biological Chemistry

The protein Lgl1 is a key regulator of cell polarity. We previously showed that Lgl1 is inactivated by hyperphosphorylation in glioblastoma as a consequence of PTEN tumour suppressor loss and aberrant activation of the PI 3-kinase pathway; this contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eac172f9342d10d751e70e28529ec91
http://europepmc.org/articles/PMC8551657

A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners

Autor: Christoph Wittich, Claus A. M. Seidel, Radovan Dvorsky, Soheila Rezaei Adariani, Farhad Bazgir, Ehsan Amin, Mohammad Reza Ahmadian, Neda S. Kazemein Jasemi

Publikováno v: The Journal of Biological Chemistry

RAS effectors specifically interact with GTP-bound RAS proteins to link extracellular signals to downstream signaling pathways. These interactions rely on two types of domains, called RAS-binding (RB) and RAS association (RA) domains, which share com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c908bf66f01ab88e26b2531338812873
http://europepmc.org/articles/PMC8163975

Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease

Autor: Tawni Dornelles, Rachel E Hodgson, Mark P. Ashe, Susan G. Campbell, Benjamin Abell, Karl Norris, K Elizabeth Allen

Publikováno v: The Journal of Biological Chemistry
Norris, K, Hodgson, R E, Dornelles, T, Allen, K E, Abell, B M, Ashe, M P & Campbell, S G 2020, ' Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease ', The Journal of biological chemistry . https://doi.org/10.1074/jbc.RA120.014956

Eukaryotic initiation factor 2B (eIF2B) serves as a vital control point within protein synthesis and regulates translation initiation in response to cellular stress. Mutations within eIF2B result in the fatal disease, leukoencephalopathy with vanishi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bbe2734e8e96bd8429c56aebca073a
http://europepmc.org/articles/PMC7948505

Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart☆

Autor: Ward, Matthew, Iskratsch, Thomas

Publikováno v: Biochimica et Biophysica Acta. Molecular Cell Research

The composition and the stiffness of cardiac microenvironment change during development and/or in heart disease. Cardiomyocytes (CMs) and their progenitors sense these changes, which decides over the cell fate and can trigger CM (progenitor) prolifer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4179d4eefebf105245222732b8cb9ce5
http://europepmc.org/articles/PMC7042712