Zobrazeno 1 - 10 of 3 098 pro vyhledávání: '"GEF, Guanine Nucleotide Exchange Factor"'
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Gγ-like (ggl) domains: new frontiers in g-protein signaling and β-propeller scaffolding22Abbreviations: DEP, dishevelled/EGL-10/pleckstrin-related domain; DH, dbl-homology domain; GAP, guanosine triphosphatase-activating protein; GEF, guanine nucleotide exchange factor; GGL, G-gamma-like; GIRK, G-protein-gated inwardly rectifying potassium channel; GPCR, G-protein-coupled receptor; G protein, guanine nucleotide binding protein; GTPase, guanosine triphosphatase; mAChR, muscarinic acetylcholine receptor; MAPK, mitogen-activated protein kinase; PDE, phosphodiesterase; PDZ, PSD-95/Discs-large/ZO-1 related domain; PH, pleckstrin-homology domain; PI3Kγ, gamma isoform of phosphoinositide 3-kinase; PLC-β, beta isoform of phospholipase C; PTB, phosphotyrosine-binding domain; RACK1, receptor for activated C kinase type-1; RBD, Ras-binding domain; RGS, regulators of G-protein signaling; and SAPK, stress-activated protein kinase
Autor: John Sondek, David P. Siderovski
Publikováno v: Biochemical Pharmacology. 61:1329-1337
The standard model of signal transduction from G-protein-coupled receptors (GPCRs) involves guanine nucleotide cycling by a heterotrimeric G-protein assembly composed of Galpha, Gbeta, and Ggamma subunits. The WD-repeat beta-propeller protein Gbeta a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62a0361eadbe11c7ed872fd467c834b6
https://doi.org/10.1016/s0006-2952(01)00633-5
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2
Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5
Autor: Mo Wang, C. Chris Yun, Yiran Han, Lei Dong, Peijian He
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1073-1092 (2021)
Background & Aims Epithelial cells form a monolayer at mucosal surface that functions as a highly selective barrier. Lysophosphatidic acid (LPA) is a bioactive lipid that elicits a broad range of biological effects via cognate G protein-coupled recep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76070d2010df41333ad81cb10e8a8f40
http://europepmc.org/articles/PMC8350072
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3
Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anticancer activities in lung adenocarcinoma
Autor: Hemant Kumar, Yoav Peleg, Ariel Erijman, Julia M. Shifman, Ashish Noronha, Anamika Singh, Yosef Yarden
Publikováno v: The Journal of Biological Chemistry
Within the superfamily of small GTPases, Ras appears to be the master regulator of such processes as cell cycle progression, cell division, and apoptosis. Several oncogenic Ras mutations at amino acid positions 12, 13, and 61 have been identified tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6e501be983b2ce2666c2a21b78ab3a
http://europepmc.org/articles/PMC8605244
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4
Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma
Autor: Alexander Gont, Danny Jomaa, Karen Jardine, Ian A. J. Lorimer, Sylvie J. Lavictoire, David P. Cook
Publikováno v: The Journal of Biological Chemistry
The protein Lgl1 is a key regulator of cell polarity. We previously showed that Lgl1 is inactivated by hyperphosphorylation in glioblastoma as a consequence of PTEN tumour suppressor loss and aberrant activation of the PI 3-kinase pathway; this contr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eac172f9342d10d751e70e28529ec91
http://europepmc.org/articles/PMC8551657
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5
Basolateral protein Scribble binds phosphatase PP1 to establish a signaling network maintaining apicobasal polarity
Autor: Regina B. Troyanovsky, Sergey M. Troyanovsky, Rei Kato, Indrajyoti Indra, Brian J. Mitchell
Publikováno v: The Journal of Biological Chemistry
Scribble, a member of the LAP protein family, contributes to the apicobasal polarity (ABP) of epithelial cells. The LAP-unique region of these proteins, which is essential and sufficient for ABP, includes a conserved Leucine-Rich Repeat (LRR) domain.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffc510128db201992cbbf4256e9e1dc
https://pubmed.ncbi.nlm.nih.gov/34634305
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6
A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners
Autor: Christoph Wittich, Claus A. M. Seidel, Radovan Dvorsky, Soheila Rezaei Adariani, Farhad Bazgir, Ehsan Amin, Mohammad Reza Ahmadian, Neda S. Kazemein Jasemi
Publikováno v: The Journal of Biological Chemistry
RAS effectors specifically interact with GTP-bound RAS proteins to link extracellular signals to downstream signaling pathways. These interactions rely on two types of domains, called RAS-binding (RB) and RAS association (RA) domains, which share com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c908bf66f01ab88e26b2531338812873
http://europepmc.org/articles/PMC8163975
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7
RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors
Autor: J.L. Gray, Christina Bitsina, Frank von Delft, Paul Brennan, Andrew P. Thompson
Publikováno v: The Journal of Biological Chemistry
The human dedicator of cytokinesis (DOCK) family consists of 11 structurally conserved proteins that serve as atypical RHO guanine nucleotide exchange factors (RHO GEFs). These regulatory proteins act as mediators in numerous cellular cascades that p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a6616905efc2a2ef77da8d684aca0b
http://europepmc.org/articles/PMC8063744
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8
Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease
Autor: Tawni Dornelles, Rachel E Hodgson, Mark P. Ashe, Susan G. Campbell, Benjamin Abell, Karl Norris, K Elizabeth Allen
Publikováno v: The Journal of Biological Chemistry
Norris, K, Hodgson, R E, Dornelles, T, Allen, K E, Abell, B M, Ashe, M P & Campbell, S G 2020, ' Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease ', The Journal of biological chemistry . https://doi.org/10.1074/jbc.RA120.014956
Eukaryotic initiation factor 2B (eIF2B) serves as a vital control point within protein synthesis and regulates translation initiation in response to cellular stress. Mutations within eIF2B result in the fatal disease, leukoencephalopathy with vanishi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bbe2734e8e96bd8429c56aebca073a
http://europepmc.org/articles/PMC7948505
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9
Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling
Autor: Hironori Inaba, Takao Nakata, Qianqian Miao
Publikováno v: The Journal of Biological Chemistry
Rho/Ras family small GTPases are known to regulate numerous cellular processes, including cytoskeletal reorganization, cell proliferation, and cell differentiation. These processes are also controlled by Ca2+, and consequently, cross talk between the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140bda14014405287b83abe6cfc634b1
http://europepmc.org/articles/PMC7949103
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10
Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart☆
Autor: Ward, Matthew, Iskratsch, Thomas
Publikováno v: Biochimica et Biophysica Acta. Molecular Cell Research
The composition and the stiffness of cardiac microenvironment change during development and/or in heart disease. Cardiomyocytes (CMs) and their progenitors sense these changes, which decides over the cell fate and can trigger CM (progenitor) prolifer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4179d4eefebf105245222732b8cb9ce5
http://europepmc.org/articles/PMC7042712
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