Artificial Gravity as a Bone Loss Countermeasure in Simulated Weightlessness

Autor: Sara R. Zwart, Linda Shackelford, Adrian LeBlanc, GE Crawford, PL Gillman, Martina Heer, Scott M. Smith

Publikováno v: The FASEB Journal. 21

The impact of microgravity on the human body is a significant concern for space travelers. We report here initial results from a pilot study designed to explore the utility of artificial gravity (AG) as a countermeasure to the effects of microgravity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ea454c9f7f1f8e443e8282a2263d254
https://doi.org/10.1096/fasebj.21.5.a174-c

Promoter Deletion Leading to Allele Specific Expression in a Genetically Unsolved Case of Primary Ciliary Dyskinesia.

Autor: Beaman MM; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, North Carolina, USA.; Medical Scientist Training Program, Duke University, Durham, North Carolina, USA.; University Program in Genetics & Genomics, Duke University, Durham, North Carolina, USA., Yin W; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Smith AJ; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Sears PR; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Leigh MW; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Ferkol TW; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Kearney B; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.; Center for Statistical Genetics and Genomics, Duke University, Durham, North Carolina, USA., Olivier KN; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Kimple AJ; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Otolaryngology/Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Clarke S; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.; Center for Statistical Genetics and Genomics, Duke University, Durham, North Carolina, USA., Huggins E; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, North Carolina, USA., Nading E; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, North Carolina, USA., Jung SH; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, North Carolina, USA., Iyengar AK; University Program in Genetics & Genomics, Duke University, Durham, North Carolina, USA.; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.; Center for Statistical Genetics and Genomics, Duke University, Durham, North Carolina, USA., Zou X; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.; Center for Statistical Genetics and Genomics, Duke University, Durham, North Carolina, USA.; Program in Computational Biology & Bioinformatics, Duke University, Durham, North Carolina, USA., Dang H; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Barrera A; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.; Center for Statistical Genetics and Genomics, Duke University, Durham, North Carolina, USA., Majoros WH; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.; Center for Statistical Genetics and Genomics, Duke University, Durham, North Carolina, USA., Rehder CW; Department of Pathology, Duke University, Durham, North Carolina, USA., Reddy TE; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.; Center for Statistical Genetics and Genomics, Duke University, Durham, North Carolina, USA., Ostrowski LE; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Allen AS; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.; Center for Statistical Genetics and Genomics, Duke University, Durham, North Carolina, USA., Knowles MR; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Zariwala MA; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Crawford GE; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, North Carolina, USA.

Publikováno v: American journal of medical genetics. Part A [Am J Med Genet A] 2025 Feb; Vol. 197 (2), pp. e63880. Date of Electronic Publication: 2024 Oct 04.

Single-nucleus multi-omics of Parkinson's disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks.

Autor: Shwab EK; Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, 27708, USA., Gingerich DC; Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, 27708, USA., Man Z; Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, 27708, USA., Gamache J; Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, 27708, USA., Garrett ME; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27701, USA., Crawford GE; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, 27708, USA.; Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27708, USA.; Center for Advanced Genomic Technologies, Duke University Medical Center, Durham, NC, 27708, USA., Ashley-Koch AE; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27701, USA.; Department of Medicine, Duke University Medical Center, Durham, NC, 27708, USA., Serrano GE; Banner Sun Health Research Institute, Sun City, AZ, 85351, USA., Beach TG; Banner Sun Health Research Institute, Sun City, AZ, 85351, USA., Lutz MW; Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Duke University Medical Center, Durham, NC, 27710, USA., Chiba-Falek O; Division of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Duke University Medical Center, Durham, NC, 27710, USA. o.chibafalek@duke.edu.; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, 27708, USA. o.chibafalek@duke.edu.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Jul 02; Vol. 12 (1), pp. 111. Date of Electronic Publication: 2024 Jul 02.

Chromatin Remodeling in Patient-Derived Colorectal Cancer Models.

Autor: Xiang K; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Wang E; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Mantyh J; Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA., Rupprecht G; Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA., Negrete M; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Sanati G; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Hsu C; Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA., Randon P; Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, 27709, USA., Dohlman A; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Kretzschmar K; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Uppsalalaan 8, Utrecht, CT, 3584, The Netherlands.; Mildred Scheel Early Career Centre (MSNZ) for Cancer Research Würzburg, University Hospital Würzburg, 97080, Würzburg, Germany., Bose S; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Giroux N; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Ding S; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Wang L; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Balcazar JP; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Huang Q; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA.; Terasaki Institute, Los Angeles, CA, 90024, USA., Sundaramoorthy P; Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA., Xi R; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., McCall SJ; Department of Pathology, School of Medicine, Duke University, Durham, NC, 27710, USA., Wang Z; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA., Jiang C; Terasaki Institute, Los Angeles, CA, 90024, USA., Kang Y; Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA., Kopetz S; Department of Gastrointestinal (GI) Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Crawford GE; Department of Pediatrics, Division of Medical Genetics, School of Medicine, Duke University, Durham, NC, 27710, USA., Lipkin SM; Department of Medicine and Program in Mendelian Genetics, Weill Cornell Medicine, New York, NY, 10021, USA., Wang XF; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27710, USA., Clevers H; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, Uppsalalaan 8, Utrecht, CT, 3584, The Netherlands., Hsu D; Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA., Shen X; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, 27708, USA.; Terasaki Institute, Los Angeles, CA, 90024, USA.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Apr; Vol. 11 (16), pp. e2303379. Date of Electronic Publication: 2024 Feb 21.

Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus.

Autor: Dai J; Department of Molecular Genetics and Microbiology, Center for Virology, Duke University School of Medicine, Durham, North Carolina, USA., SoRelle ED; Department of Molecular Genetics and Microbiology, Center for Virology, Duke University School of Medicine, Durham, North Carolina, USA., Heckenberg E; Department of Molecular Genetics and Microbiology, Center for Virology, Duke University School of Medicine, Durham, North Carolina, USA., Song L; Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA.; Division of Medical Genetics, Department of Pediatrics, Duke University, Durham, North Carolina, USA., Cable JM; Department of Molecular Genetics and Microbiology, Center for Virology, Duke University School of Medicine, Durham, North Carolina, USA., Crawford GE; Center for Genomic & Computational Biology, Duke University, Durham, North Carolina, USA.; Division of Medical Genetics, Department of Pediatrics, Duke University, Durham, North Carolina, USA., Luftig MA; Department of Molecular Genetics and Microbiology, Center for Virology, Duke University School of Medicine, Durham, North Carolina, USA.

Publikováno v: MBio [mBio] 2024 Jan 16; Vol. 15 (1), pp. e0244423. Date of Electronic Publication: 2023 Dec 07.