Výsledky vyhledávání - "GDP, Guanosine diphosphate"

Ginsenosides in Panax genus and their biosynthesis

Autor: Zhengtao Wang, Shujuan Zhao, Rufeng Wang, Maoqi Hou

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1813-1834 (2021)
Acta Pharmaceutica Sinica. B

Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol (PPD)-, protopanaxatriol (PPT)-, ocotillol (OCT)- and oleanane (OA)-type saponins known as active compounds of Panax genus. They are accumulated in plant roots, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3ebd6a887266674e75c6007dc0b127
https://doi.org/10.1016/j.apsb.2020.12.017

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A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and AutophagySummary

Autor: Iulia Oancea, Andy Wu, Michael A. McGuckin, Sumaira Z. Hasnain, Rabina Giri, John D. Hooper, Veronika Schreiber, Brett C McWhinney, Julie M. Davies, Jakob Begun, Yonghua Sheng, David P. Fairlie, Saleh Y. Alabbas, Gregor Kijanka, Yaowu He, Ramya Movva, Andrew J. Lucke, Timothy H. Florin

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 33-53 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD). Abnormal Wnt/β-catenin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f601ccce23a182b6171ce5a7c5598ec
http://www.sciencedirect.com/science/article/pii/S2352345X20300886

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Akademický článek

Stabilization of interdomain closure by a G protein inhibitor.

Autor: Todd, Tyson D., Vithani, Neha, Singh, Sukrit, Bowman, Gregory R., Blumer, Kendall J., Soranno, Andrea

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 9/3/2024, Vol. 121 Issue 36, p1-11, 46p

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Biochemistry of the Macrolide Antibiotics11The following abbreviations have been used in this article: CoA, coenzyme A; ACP, acyl-carrier protein; NAD, nicotinamide adenine dinucleotide; NADPH, reduced nicotinamide adenine dinucleotide phosphate; CDP, cytidine diphosphate; GDP, guanosine diphosphate; TDP, thymidine diphosphate

Autor: Malcolm Chick, John W. Corcoran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::396a1ce6f332e6e1a14f0453144406da
https://doi.org/10.1016/b978-0-12-395530-2.50011-1

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RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors

Autor: J.L. Gray, Christina Bitsina, Frank von Delft, Paul Brennan, Andrew P. Thompson

Publikováno v: The Journal of Biological Chemistry

The human dedicator of cytokinesis (DOCK) family consists of 11 structurally conserved proteins that serve as atypical RHO guanine nucleotide exchange factors (RHO GEFs). These regulatory proteins act as mediators in numerous cellular cascades that p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a6616905efc2a2ef77da8d684aca0b
http://europepmc.org/articles/PMC8063744

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The requirement for cobalt in vitamin B12: A paradigm for protein metalation☆

Autor: Tessa R. Young, Evelyne Deery, Anastasia Cooke, Martin J. Warren, Deenah Osman, Nigel J. Robinson

Publikováno v: Biochimica et Biophysica Acta. Molecular Cell Research

Vitamin B12, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that represents one of the most complex small molecules made by nature. In prokaryotes it is utilised as a cofactor, coenzyme, light sensor and gene regulator yet ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ace2dec5de2d9cde658800a4c92af8b
http://europepmc.org/articles/PMC7689651

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Dietary Protein and Amino Acid Deficiency Inhibit Pancreatic Digestive Enzyme mRNA Translation by Multiple Mechanisms

Autor: John A. Williams, Nancy L. Vogel, Maria Dolors Sans, Louis G. D'Alecy, Stephen J. Crozier

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 99-115 (2021)

Background & Aims Chronic amino acid (AA) deficiency, as in kwashiorkor, reduces the size of the pancreas through an effect on mammalian target of rapamycin complex 1 (mTORC1). Because of the physiological importance of AAs and their role as a substr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdfa7077fd78998f54db32a754523b3
https://pubmed.ncbi.nlm.nih.gov/32735995

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gRASping the redox lever to modulate cancer cell fate signaling

Autor: Chuan Han Jonathan Foo, Shazib Pervaiz

Publikováno v: Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biology

RAS proteins are critical regulators of signaling networks controlling diverse cellular functions such as cell proliferation and survival and its mutation are among the most powerful oncogenic drivers in human cancers. Despite intense efforts, direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11cd3c78529b5f4eae7369f41a3e411
http://www.sciencedirect.com/science/article/pii/S2213231718311558

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Targeting ADP-ribosylation as an antimicrobial strategy

Autor: Giovanna Grimaldi, Carmen Valente, Giuliana Catara, Annunziata Corteggio, Luca Palazzo

Publikováno v: Biochemical Pharmacology
Biochemical pharmacology 167 (2019): 13–26. doi:10.1016/j.bcp.2019.06.001
info:cnr-pdr/source/autori:Catara, Giuliana; Corteggio, Annunziata; Valente, Carmen; Grimaldi, Giovanna; Palazzo, Luca/titolo:Targeting ADP-ribosylation as an antimicrobial strategy/doi:10.1016%2Fj.bcp.2019.06.001/rivista:Biochemical pharmacology/anno:2019/pagina_da:13/pagina_a:26/intervallo_pagine:13–26/volume:167

Graphical abstract
ADP-ribosylation (ADPr) is an ancient reversible modification of cellular macromolecules controlling major biological processes as diverse as DNA damage repair, transcriptional regulation, intracellular transport, immune and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b75a92558b9e6288c6602ac3398b2c6
https://pubmed.ncbi.nlm.nih.gov/31176616

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Noonan syndrome-causing genes: Molecular update and an assessment of the mutation rate

Autor: Mohammed Iraqui Houssaini, Samir Atmani, Ihssane El Bouchikhi, Khadija Belhassan, Karim Ouldim, Fatima Zohra Moufid, Laila Bouguenouch, Imane Samri

Publikováno v: International Journal of Pediatrics & Adolescent Medicine
International Journal of Pediatrics and Adolescent Medicine, Vol 3, Iss 4, Pp 133-142 (2016)

Noonan syndrome is a common autosomal dominant disorder characterized by short stature, congenital heart disease and facial dysmorphia with an incidence of 1/1000 to 2500 live births. Up to now, several genes have been proven to be involved in the di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30e90f717f374a42b7ecb6fb885f044
https://doi.org/10.1016/j.ijpam.2016.06.003

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