Zobrazeno 1 - 10
of 117
pro vyhledávání: '"GDNF family ligands"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Well-known effects of neurotrophic factors are related to supporting the survival and functioning of various neuronal populations in the body. However, these proteins seem to also play less well-documented roles in glial cells, thus, influencing neur
Externí odkaz:
https://doaj.org/article/240c79037cac4ac08876fff307404cfe
Publikováno v:
Cells, Vol 9, Iss 4, p 865 (2020)
The neurotrophic factors are well known for their implication in the growth and the survival of the central, sensory, enteric and parasympathetic nervous systems. Due to these properties, neurturin (NRTN) and Glial cell-derived neurotrophic factor (G
Externí odkaz:
https://doaj.org/article/dda4ece38bae4eb9a4c24b835df35ec6
Autor:
Pia Runeberg-Roos, Richard D. Penn
Publikováno v:
Cell and Tissue Research
The last decade has been a frustrating time for investigators who had envisioned major advances in the treatment of Parkinson’s disease using neurotrophic factors. The first trials of glial cell line–derived neurotrophic factor for treating Parki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79d58781bcf3c4b2155c20ef4d1542b
https://doi.org/10.1007/s00441-020-03256-z
https://doi.org/10.1007/s00441-020-03256-z
Autor:
Yulia A. Sidorova, Maxim M. Bespalov, Agnes W. Wong, Oleg Kambur, Viljami Jokinen, Tuomas O. Lilius, Ilida Suleymanova, Gunnar Karelson, Pekka V. Rauhala, Mati Karelson, Peregrine B. Osborne, Janet R. Keast, Eija A. Kalso, Mart Saarma
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Neuropathic pain caused by nerve damage is a common and severe class of chronic pain. Disease-modifying clinical therapies are needed as current treatments typically provide only symptomatic relief; show varying clinical efficacy; and most have signi
Externí odkaz:
https://doaj.org/article/386952903bfa44e9aacfe166bb459eff
Autor:
Arun Kumar Mahato, Yulia Sidorova
Publikováno v:
Cell and Tissue Research
Rearranged during transfection (RET), in complex with glial cell line-derived (GDNF) family receptor alpha (GFRα), is the canonical signaling receptor for GDNF family ligands (GFLs) expressed in both central and peripheral parts of the nervous syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b3c3a02138f9f21fc1fca375e460f9
https://doi.org/10.1007/s00441-020-03227-4
https://doi.org/10.1007/s00441-020-03227-4
Well-known effects of neurotrophic factors are related to supporting the survival and functioning of various neuronal populations in the body. However, these proteins seem to also play less well-documented roles in glial cells, thus, influencing neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1593::57c144591d3fc8399a5396b6c634def8
http://hdl.handle.net/10138/332606
http://hdl.handle.net/10138/332606
Autor:
Francesca M. Houghton, Andrea Nans, Christopher Earl, Neil Q. McDonald, Svend Kjaer, Pauline B. McIntosh, David Briggs, Phillip P. Knowles, Andrew Purkiss, Sarah E. Adams, Agata Nawrotek, Kerry M. Goodman, Aaron J. Borg, Annabel Borg
Publikováno v:
Structure(London, England:1993)
Summary RET receptor tyrosine kinase plays vital developmental and neuroprotective roles in metazoans. GDNF family ligands (GFLs) when bound to cognate GFRα co-receptors recognize and activate RET stimulating its cytoplasmic kinase function. The pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4a4294b6a753737fb2a4f8fea66864
https://doi.org/10.1016/j.str.2020.12.012
https://doi.org/10.1016/j.str.2020.12.012
Autor:
Runeberg-Roos, Pia, Penn, Richard D.
The last decade has been a frustrating time for investigators who had envisioned major advances in the treatment of Parkinson's disease using neurotrophic factors. The first trials of glial cell line-derived neurotrophic factor for treating Parkinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1593::30d618a138149ccfdd5abe6e302e8897
http://hdl.handle.net/10138/321075
http://hdl.handle.net/10138/321075
Autor:
Mahato, Arun Kumar, Sidorova, Yulia A.
Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal circumstances interacts with ligand at the cell surface and mediates various essential roles in a variety of cellular processes such as proliferation, differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1593::2e112cb863f1546f000b5f68b6193bb4
http://hdl.handle.net/10138/326615
http://hdl.handle.net/10138/326615
Autor:
Mahato, Arun Kumar, Sidorova, Yulia A.
Rearranged during transfection (RET), in complex with glial cell line-derived (GDNF) family receptor alpha (GFR alpha), is the canonical signaling receptor for GDNF family ligands (GFLs) expressed in both central and peripheral parts of the nervous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1593::4eb8b05ce8bb446c9825908444214283
http://hdl.handle.net/10138/320367
http://hdl.handle.net/10138/320367