Výsledky vyhledávání

Patrolling monocytes control tumor metastasis to the lung

Autor: RN, Hanna, C, Cekic, D, Sag, R, Tacke, GD, Thomas, H, Nowyhed, E, Herrley, N, Rasquinha, S, McArdle, R, Wu, E, Peluso, D, Metzger, Ichinose, Hiroshi, I, Shaked, G, Chodaczek, SK, Biswas, CC, Hedrick

Publikováno v: Science

Monocytes block tumor access to the lung Metastatic cancer is especially hard to treat. In order to find potential new therapeutic targets, scientists are trying to understand the cellular events that promote or prevent metastasis. Hanna et al. now r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c394ab33a59d05f6260f8aeca58fed2
https://pubmed.ncbi.nlm.nih.gov/26494174

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Optimal tumor targeting by antibodies: Development of a mathematical model

Autor: Arthur R. Bradwell, GD Thomas, Michael J. Chappell, Keith R. Godfrey

Publikováno v: Journal of Pharmacokinetics and Biopharmaceutics. 19:227-260

A mathematical model has been developed to optimize tumor targeting with labeled antibodies. The model is compartmental and nonlinear, incorporating saturable binding. Published parameter values have been used in the model, and the resulting stiff di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c623a4126e7095585fe4594d043c56a
https://doi.org/10.1007/bf01073870

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Antibody targeting: Theoretical considerations

Autor: P.W. Dykes, Arthur R. Bradwell, GD Thomas

Publikováno v: Cancer Imaging with Radiolabeled Antibodies ISBN: 9781461288053

The detection of tumors using radiolabeled antibodies has been usefully applied to many tumor types [1]. Many important factors can be defined and thereby developed into mathematical models to assess the potential and limitations of the technique. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ed995302f17ebd22770dff1bf31bc8a
https://doi.org/10.1007/978-1-4613-1497-4_2

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Antibody imaging of endocrine tumors

Autor: P.W. Dykes, GD Thomas, Catherine Chapman, Arthur R. Bradwell

Publikováno v: Cancer Imaging with Radiolabeled Antibodies ISBN: 9781461288053

Accurate localization of relatively slow-growing endocrine tumors, where removal may be curative or at least reduce symptoms from the released hormones, has considerable clinical importance. This applies to parathyroid adenomas, pancreatic tumors (in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01ce7bc8c3f466054e9dea3ed0ae5b51
https://doi.org/10.1007/978-1-4613-1497-4_17

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Effect of dose, molecular size, affinity, and protein binding on tumor uptake of antibody or ligand: a biomathematical model

Autor: Gd, Thomas, Mj, Chappell, Pw, Dykes, Db, Ramsden, Kr, Godfrey, Jr, Ellis, Arthur Bradwell

Publikováno v: Europe PubMed Central

A mathematical model has been developed to determine the best approach to improving tumor targeting with antibody. The amount of antibody in the tumor (tumor content) and the tumor:normal tissue antibody concentration ratio (uptake ratio) were calcul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::268e98f88a052d8f04ede853ebc33a13
http://europepmc.org/abstract/med/2720683

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