Výsledky vyhledávání - "GCL, glutamate cysteine ligase"

Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice

Autor: Jephte Y. Akakpo, Qingyun Bai, Xiao Yang, Li Yang, Thomas Rülicke, Lili Ji, Kurt Zatloukal, Wen-Xing Ding, Hong-Min Ni, Hui Qian, Hartmut Jaeschke

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3791-3805 (2021)

Acetaminophen (APAP) overdose can induce liver injury and is the most frequent cause of acute liver failure in the United States. We investigated the role of p62/SQSTM1 (referred to as p62) in APAP-induced liver injury (AILI) in mice. We found that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822a9d722ce09297bbb1ac56b38e95ad
https://pubmed.ncbi.nlm.nih.gov/35024307

Zobrazit plný text záznamu

Oxidative profile exhibited by Mucopolysaccharidosis type IVA patients at diagnosis: Increased keratan urinary levels

Autor: Carmen Regla Vargas, Bruna Donida, Helen Tais da Rosa, Roberto Giugliani, Graziela S. Ribas, Jenifer Saffi, Marion Deon, Carlos Eduardo Diaz Jacques, Paula R. Manini, Desirèe Padilha Marchetti, Dinara Jaqueline Moura

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 11, Iss C, Pp 46-53 (2017)
Molecular Genetics and Metabolism Reports

Morquio A disease (Mucopolysaccharidosis type IVA, MPS IVA) is one of the 11 mucopolysaccharidoses (MPSs), a heterogeneous group of inherited lysosomal storage disorders (LSDs) caused by deficiency in enzymes need to degrade glycosaminoglycans (GAGs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83981f248cbaa05dd8322a825abad972
https://doi.org/10.1016/j.ymgmr.2017.04.005

Zobrazit plný text záznamu

Oral administration of γ-glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study

Autor: Martin Hani Zarka, Wallace Bridge

Publikováno v: Redox Biology, Vol 11, Iss, Pp 631-636 (2017)
Redox Biology

Objective To determine if orally dosed γ-glutamylcysteine (γ-GC) can increase cellular glutathione (GSH) levels above homeostasis. Many chronic and age-related disorders are associated with down-regulation, or impairment, of glutamate cysteine liga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a436b2d6187b445f8959f08e3bc562c4
http://www.sciencedirect.com/science/article/pii/S2213231716303718

Zobrazit plný text záznamu

Quercetin affects glutathione levels and redox ratio in human aortic endothelial cells not through oxidation but formation and cellular export of quercetin-glutathione conjugates and upregulation of glutamate-cysteine ligase

Autor: Balz Frei, Jaewoo Choi, Chuan Li, Wei-Jian Zhang

Publikováno v: Redox Biology, Vol 9, Iss C, Pp 220-228 (2016)
Redox Biology

Endothelial dysfunction due to vascular inflammation and oxidative stress critically contributes to the etiology of atherosclerosis. The intracellular redox environment plays a key role in regulating endothelial cell function and is intimately linked

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc4299273c8cf28d0e45901932a9fc0
http://www.sciencedirect.com/science/article/pii/S2213231716301240

Zobrazit plný text záznamu

Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells

Autor: Betul Karademir, Perinur Bozaykut, Nesrin Kartal Ozer

Publikováno v: Redox Biology, Vol 8, Iss C, Pp 323-332 (2016)
Redox Biology

Nrf2 pathway has been known to be protective against cancer progression however recent studies have revealed that the antioxidant activity of Nrf2 contributes to chemotherapy resistance. For many years, hyperthermia has been used as an additional the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c799f61c8643bd19c1a4d01c8212da
http://www.sciencedirect.com/science/article/pii/S2213231716300209

Zobrazit plný text záznamu

Lipoxidation and cancer immunity

Autor: Paula Laranjeira, Artur Paiva, M.R. Domingues, Carmen Martín-Sierra

Publikováno v: Redox Biology
Redox Biology, Vol 23, Iss, Pp-(2019)

Lipoxidation is a well-known reaction between electrophilic carbonyl species, formed during oxidation of lipids, and specific proteins that, in most cases, causes an alteration in proteins function. This can occur under physiological conditions but,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c79b203ecef18bc579d03b65d11f13

Zobrazit plný text záznamu

Redox signaling in acute pancreatitis

Autor: Javier Pereda, Luis Sabater, Juan Sastre, Salvador Pérez

Publikováno v: Redox Biology, Vol 5, Iss, Pp 1-14 (2015)
Redox Biology

Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may lead to a severe systemic inflammatory response. A key event in pancreatic damage is the intracellular activation of NF-κB and zymogens, involving also calcium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb56911ba099d9fead4ed389905fc86
http://www.sciencedirect.com/science/article/pii/S2213231715000154

Zobrazit plný text záznamu

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

Autor: Huijuan Jin, Dhulfiqar Ali Abed, Haifa Albanyan, Melanie Goldstein, Longqin Hu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 5, Iss 4, Pp 285-299 (2015)
Acta Pharmaceutica Sinica. B

The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction (PPI) has become an important drug target to upregulate the expression of ARE-co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e376506c73d1e50dafd120221447bd0a
http://www.sciencedirect.com/science/article/pii/S2211383515000829

Zobrazit plný text záznamu

Role of glutathione biosynthesis in endothelial dysfunction and fibrosis

Autor: Verónica Miguel, Susana Vallejo, Pablo Cannata, Eva Maria Blanco, Concepción Peiró, Elena Sandoval, Francisco Sánchez, Carlos F. Sánchez-Ferrer, Santiago Lamas, Cristina Espinosa-Diez

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Redox Biology
Redox Biology, Vol 14, Iss, Pp 88-99 (2018)
Digital.CSIC. Repositorio Institucional del CSIC

Glutathione (GSH) biosynthesis is essential for cellular redox homeostasis and antioxidant defense. The rate-limiting step requires glutamate-cysteine ligase (GCL), which is composed of the catalytic (GCLc) and the modulatory (GCLm) subunits. To eval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c1c7b88fff95766c4d77f2f8680468
https://hdl.handle.net/20.500.12530/42459

Zobrazit plný text záznamu

Hippocampal neurons require a large pool of glutathione to sustain dendrite integrity and cognitive function

Autor: Juan P. Bolaños, Monica Carabias-Carrasco, Angeles Almeida, Silvia Gonzalez-Fernandez, Monica Resch, Joaquim Ros, Seila Fernandez-Fernandez, Raquel Requejo-Aguilar, Veronica Bobo-Jimenez

Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Redox Biology, Vol 19, Iss, Pp 52-61 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Recercat. Dipósit de la Recerca de Catalunya
Redox Biology

Loss of brain glutathione has been associated with cognitive decline and neuronal death during aging and neurodegenerative diseases. However, whether decreased glutathione precedes or follows neuronal dysfunction has not been unambiguously elucidated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f877997b5ac2102a2d526f9f98fb08a7
http://hdl.handle.net/10459.1/64860

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání