Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Autor: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020

Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice

Autor: Fanny Langlet, Bernard Thorens, Antoine Rohrbach, Irina Kolotuev, Emilie Caron, Roxane Pasquettaz, Federico Santoni, Rafik Dali, Maxime Brunner

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 53, Iss, Pp 101311-(2021)

Objectives Glucokinase (GCK) is critical for glucosensing. In rats, GCK is expressed in hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this study, we investigated the distribution of GCK-expressing tanycytes in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c27ff32b82421b71e5764fb0b90600
https://pubmed.ncbi.nlm.nih.gov/34325016

Counter-regulatory responses to

Autor: Toyin Mohammed, Salman, Isiaka Abdullateef, Alagbonsi, Sheu Oluwadare, Sulaiman

Publikováno v: Metabolism Open

Background Telfairia occidentalis (TO) has many biological activities including blood glucose regulation. Thus, it is being used in the treatment of diabetes mellitus. TO has been shown to cause insulin-mediated hypoglycaemia, which leads to post-hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::233c973b9d0484b645de539d1e86c2df
https://pubmed.ncbi.nlm.nih.gov/33235989

Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

Autor: Chakera, Ali J., Hurst, Paul S., Spyer, Gill, Ogunnowo-Bada, Emmanuel O., Marsh, William J., Riches, Christine H., Yueh, Chen-Yu, Markkula, S. Pauliina, Dalley, Jeffrey W., Cox, Roger D., Macdonald, Ian A., Amiel, Stephanie A., MacLeod, Kenneth M., Heisler, Lora K., Hattersley, Andrew T., Evans, Mark L.

Publikováno v: Molecular Metabolism, Vol 17, Iss, Pp 17-27 (2018)
Chakera, A J, Hurst, P S, Spyer, G, Ogunnowo-Bada, E O, Marsh, W J, Riches, C H, Yueh, C Y, Markkula, S P, Dalley, J W, Cox, R D, Macdonald, I A, Amiel, S A, MacLeod, K M, Heisler, L K, Hattersley, A T & Evans, M L 2018, ' Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes ', Molecular Metabolism . https://doi.org/10.1016/j.molmet.2018.08.001
Molecular Metabolism

Objective Appropriate glucose levels are essential for survival; thus, the detection and correction of low blood glucose is of paramount importance. Hypoglycemia prompts an integrated response involving reduction in insulin release and secretion of k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3790757ba77e77647b9ef28458dabd9a
http://www.sciencedirect.com/science/article/pii/S2212877818307506

Does broodstock nutritional history affect the response of progeny to different first-feeding diets? A whole-body transcriptomic study of rainbow trout alevins

Autor: Geneviève Corraze, Françoise Médale, Laurence Larroquet, David Mazurais, Viviana Lazzarotto

Publikováno v: British Journal of Nutrition
British Journal of Nutrition, Cambridge University Press (CUP), 2016, 115 (12), pp.2079--2092. ⟨10.1017/S0007114516001252⟩
British Journal Of Nutrition (0007-1145) (Cambridge Univ Press), 2016-06, Vol. 115, N. 12, P. 2079-2092
British Journal of Nutrition, 2016, 115 (12), pp.2079-2092. ⟨10.1017/S0007114516001252⟩
British Journal of Nutrition, Cambridge University Press (CUP), 2016, 115 (12), pp.2079-2092. ⟨10.1017/S0007114516001252⟩

The whole-body transcriptome of trout alevins was characterised to investigate the effects of long-term feeding of rainbow trout broodstock females a diet free of fishmeal and fish oil on the metabolic capacities of progeny. Effects were studied befo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94e00983ea9225ddbec29b139687c34
https://hal.archives-ouvertes.fr/hal-01483272