Zobrazeno 1 - 10
of 415
pro vyhledávání: '"GCH1"'
Publikováno v:
Antioxidants, Vol 13, Iss 5, p 577 (2024)
Brucella virulence relies on its successful intracellular life cycle. Modulating host cell death is a strategy for Brucella to survive and replicate intracellularly. Ferroptosis is a novel regulated cell death characterized by iron-triggered excessiv
Externí odkaz:
https://doaj.org/article/6772687f4f52453d836314ac5ed3815f
Autor:
Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao, Daming Cui
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-20 (2022)
Abstract Background Ferroptosis is a novel form of iron-dependent cell death and participates in the malignant progression of glioblastoma (GBM). Although circular RNAs (circRNAs) are found to play key roles in ferroptosis via several mechanisms, inc
Externí odkaz:
https://doaj.org/article/74a845b5cd5f4c61a5aa5a5f72f25405
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Yinan Liu, Ertao Zhai, Junting Chen, Yan Qian, Risheng Zhao, Yan Ma, Jianqiu Liu, Zhixin Huang, Shirong Cai, Jianhui Chen
Publikováno v:
Cancer Communications, Vol 42, Iss 4, Pp 327-344 (2022)
Abstract Background Methyltransferase 3 (METTL3)‐mediated N6‐methyladenosine (m6A) RNA modification has been demonstrated to be a potential factor in promoting gastric cancer (GC). METTL3 regulates a series of signaling pathways by modifying vari
Externí odkaz:
https://doaj.org/article/436015b32ff04e44934645246c9f01ba
Publikováno v:
Xin yixue, Vol 53, Iss 1, Pp 70-73 (2022)
Dopa-responsive dystonia（DRD） is an autosomal dominant or recessive dyskinesia, which is pathologically characterized with reduced amount of dopamine in the substantia nigra and striatum. DRD is mainly manifested with dystonian in early childhood
Externí odkaz:
https://doaj.org/article/ebcc7b966a6c43c583356913e4138aa7
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Dopa-responsive dystonia (DRD) comprises a group of rare but treatable dystonias that exhibit diurnal fluctuation. The GCH1 gene encodes GTP cyclohydrolase-1 (GTPCH-І), a protein that catalyzes the first rate-limiting step of tetrahydrobiopterin bio
Externí odkaz:
https://doaj.org/article/129f105292504b12b15727f2a4e18ad1
Autor:
Nan Tao, Bopu Cheng, Hongmei Chai, Xianghua Cui, Yuanhao Ma, Jinping Yan, Yongchang Zhao, Weimin Chen
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Guanosine triphosphate (GTP) cyclohydrolase I (GCH1) is the limiting enzyme of the tetrahydrobiopterin (BH4) synthesis pathway. The disruption of gch1 gene may cause conditional lethality due to folic acid auxotrophy in microorganisms, although the f
Externí odkaz:
https://doaj.org/article/d6ddf002b37c49ac91de39206ca1db2e
Autor:
Hong-xu Pan, Yu-wen Zhao, Jun-pu Mei, Zheng-huan Fang, Yige Wang, Xun Zhou, Yang-jie Zhou, Rui Zhang, Kai-lin Zhang, Li Jiang, Qian Zeng, Yan He, Zheng Wang, Zhen-hua Liu, Qian Xu, Qi-ying Sun, Yang Yang, Ya-cen Hu, Ya-se Chen, Juan Du, Li-fang Lei, Hai-nan Zhang, Chun-yu Wang, Xin-xiang Yan, Lu Shen, Hong Jiang, Jie-qiong Tan, Jin-chen Li, Bei-sha Tang, Ji-feng Guo
Publikováno v:
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-12 (2020)
Abstract Background Common and rare variants of guanosine triphosphate cyclohydrolase 1 (GCH1) gene may play important roles in Parkinson’s disease (PD). However, there is a lack of comprehensive analysis of GCH1 genotypes, especially in non-coding
Externí odkaz:
https://doaj.org/article/e37c50f7cbe541038d65d3dfff802d0e