Zobrazeno 1 - 10
of 22
pro vyhledávání: '"GC, guanylate cyclase"'
A hybrid stochastic/deterministic model of single photon response and light adaptation in mouse rods
Autor:
Sabrina Asteriti, Karl-Wilhelm Koch, Charlotte Johanna Beelen, Daniele Dell'Orco, Lorenzo Cangiano
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3720-3734 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Highlights • A hybrid stochastic/deterministic model of mouse rod phototransduction is presented. • Rod photocurrent to photovoltage conversion in darkness is accurately characterized. • Photoresponses to dim and bright
Highlights • A hybrid stochastic/deterministic model of mouse rod phototransduction is presented. • Rod photocurrent to photovoltage conversion in darkness is accurately characterized. • Photoresponses to dim and bright
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8136acd6ea6a307ba719e270e61c52a1
http://www.sciencedirect.com/science/article/pii/S2001037021002713
http://www.sciencedirect.com/science/article/pii/S2001037021002713
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3861-3876 (2020)
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3861-3876 (2020)
Graphical abstract
Highlights • Toxoplasma genome harbors at least 18 phosphodiesterases encoded by distinct genes. • Most parasite PDEs lack regulatory modules and are quite divergent from their human orthologs. • Acutely-infectious tachy
Highlights • Toxoplasma genome harbors at least 18 phosphodiesterases encoded by distinct genes. • Most parasite PDEs lack regulatory modules and are quite divergent from their human orthologs. • Acutely-infectious tachy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952729672d93971172ad6bb332f7a8ef
http://europepmc.org/articles/PMC7720076
http://europepmc.org/articles/PMC7720076
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 7 (2014)
Photoreceptor rod outer segment membrane guanylate cyclase (ROS-GC) is central to visual transduction; it generates cyclic GMP, the second messenger of the photon signal. Photoexcited rhodopsin initiates a biochemical cascade that leads to a drop in
Externí odkaz:
https://doaj.org/article/81d8f41f4ed7427d9b7558caf30a630a
Autor:
Rameshwar K Sharma, Teresa eDuda
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 5 (2012)
From its initial discovery that ROS-GC membrane guanylate cyclase is a mono-modal Ca2+-transduction system linked exclusively with the phototransduction machinery to the successive finding that it embodies a remarkable bimodal Ca2+signaling device, i
Externí odkaz:
https://doaj.org/article/7086eb621cf847ec89953c81d0e86f3f
Publikováno v:
The Journal of Biological Chemistry
In murine and bovine photoreceptors, guanylate cyclase–activating protein 2 (GCAP2) activates retinal guanylate cyclases (GCs) at low Ca2+ levels, thus contributing to the Ca2+/cGMP negative feedback on the cyclase together with its paralog guanyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c025d7be8b1010bff981b38c4e0145f3
https://doi.org/10.1016/j.jbc.2021.100619
https://doi.org/10.1016/j.jbc.2021.100619
Autor:
Sanda Despa, Michael J. Shattock, William Fuller, Karen L. Aughton, Donald M. Bers, Andrii Boguslavskyi, Erika J. Kennington, Andrew R. Hall, Davor Pavlovic
Publikováno v:
Journal of Molecular and Cellular Cardiology
In the heart, Na/K-ATPase regulates intracellular Na+ and Ca2 + (via NCX), thereby preventing Na+ and Ca2 + overload and arrhythmias. Here, we test the hypothesis that nitric oxide (NO) regulates cardiac intracellular Na+ and Ca2 + and investigate me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67996b413629f1796f810f53fa04c7e4
https://doi.org/10.1016/j.yjmcc.2013.04.013
https://doi.org/10.1016/j.yjmcc.2013.04.013
Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development
Autor:
Opher, Gileadi
Publikováno v:
Biochemical Society Transactions
Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7dee024935ed4f8da6f8f538439cb12a
https://pubmed.ncbi.nlm.nih.gov/24450636
https://pubmed.ncbi.nlm.nih.gov/24450636
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 7 (2014)
Frontiers in Molecular Neuroscience, Vol 7 (2014)
Photoreceptor rod outer segment membrane guanylate cyclase (ROS-GC) is central to visual transduction; it generates cyclic GMP, the second messenger of the photon signal. Photoexcited rhodopsin initiates a biochemical cascade that leads to a drop in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8417a49976f2ce34259f66c429ffbba4
https://pubmed.ncbi.nlm.nih.gov/24723847
https://pubmed.ncbi.nlm.nih.gov/24723847
Autor:
Takeshi Katafuchi
Publikováno v:
Bioscience Reports, Vol 33, Iss 3, p e00039 (2013)
Bioscience Reports
Bioscience Reports
In this study, Tyr808 in GC-B (guanylate cyclase-B), a receptor of the CNP (C-type natriuretic peptide), has been shown to be a critical regulator of GC-B activity. In searching for phosphorylation sites that could account for suppression of GC-B act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7594c84dd51d3148b0866c8ec81c62
http://www.bioscirep.org/bsr/033/e039/bsr033e039.htm
http://www.bioscirep.org/bsr/033/e039/bsr033e039.htm
Publikováno v:
Bioscience Reports, Vol 32, Iss 5 (2012)
Bioscience Reports
Bioscience Reports
The second messengers cAMP and cGMP mediate a multitude of physiological processes. In mammals, these cyclic nucleotides are formed by related Class III nucleotidyl cyclases, and both ACs (adenylate cyclases) and GCs (guanylate cyclases) comprise tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327488c6f46380a7b9dc2e98fae1a721
http://www.bioscirep.org/bsr/032/0491/bsr0320491.htm
http://www.bioscirep.org/bsr/032/0491/bsr0320491.htm