Zobrazeno 1 - 10
of 18
pro vyhledávání: '"GBM, glomerular basement membrane"'
Autor:
Wei Zhang, Yilan Shen, Zongshu Xian, Tao Ding, Lei Han, Dianwen Ju, Zhiyong Guo, Jiajun Fan, Xiaobin Mei, Wei Chen, Qi Bian, Zhonglian Cao, Xin Jin
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 127-142 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 127-142 (2021)
Diabetic nephropathy (DN) is considered the primary causes of end-stage renal disease (ESRD) and is related to abnormal glycolipid metabolism, hemodynamic abnormalities, oxidative stress and chronic inflammation. Antagonism of vascular endothelial gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f219822cc51b051f7ece0ce7f7e9b55
https://doi.org/10.1016/j.apsb.2020.07.002
https://doi.org/10.1016/j.apsb.2020.07.002
Autor:
Steve Mangos, Domenico Salvatore, Jochen Reiser, Ranadheer Reddy Dande, Kwi Hye Koh, Antonio C. Bianco, Chuang Chen, Joao Pedro WerneckdeCastro, Yashwanth Reddy Sudhini, Cristina Luongo, Nicholas J. Tardi, Beata Samelko, Shivangi Agarwal, Mehmet M. Altintas
Publikováno v:
EBioMedicine
EBioMedicine, Vol 72, Iss, Pp 103617-(2021)
EBioMedicine, Vol 72, Iss, Pp 103617-(2021)
Background: Nephrotic syndrome (NS) is associated with kidney podocyte injury and may occur as part of thyroid autoimmunity such as Graves’ disease. Therefore, the present study was designed to ascertain if and how podocytes respond to and regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df25212d328ab5b102e491f56f1abd6
http://europepmc.org/articles/PMC8517284
http://europepmc.org/articles/PMC8517284
Autor:
Michio Nagata, Kandai Nozu, Makoto Asahina, Kentarou Hashikami, Kazumoto Iijima, Michiyasu Takeyama
Publikováno v:
Biochemistry and Biophysics Reports, Vol 17, Iss, Pp 81-86 (2019)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Alport syndrome (AS) is an inherited disorder characterized by glomerular basement membrane (GBM) abnormality and development of chronic kidney disease at an early age. The cause of AS is a genetic mutation in type IV collagen, and more than 80% of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47db9e2226cab1e91d5e8535455c1e5
http://www.sciencedirect.com/science/article/pii/S240558081830236X
http://www.sciencedirect.com/science/article/pii/S240558081830236X
Autor:
Juan Saus, Tatiana Mikhailova, Billy G. Hudson, Jean-Christophe Harmange, Mary C Barber, Vadim Pedchenko, Sergei P. Boudko
Publikováno v:
The Journal of Biological Chemistry
We identified a genetic variant, an 8-residue appendage, of the α345 hexamer of collagen IV present in patients with glomerular basement membrane (GBM) disease, Goodpasture's disease (GP) and Alport syndrome (AS) (see Companion Paper I), and determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bef66c227debf469ab7e2859d0b4a7c
http://europepmc.org/articles/PMC8099640
http://europepmc.org/articles/PMC8099640
Autor:
Kostas Stylianou, Charalambos Stefanou, Myrtani Pieri, Constantinos Deltas, Kyriaki Antoniadou, Neoklis Makrides, Christoforos Odiatis, Oliver Gross, Dorin-Bogdan Borza, Gregory Papagregoriou, Pavlos Ioannou, Georgios Nikolaou, Isavella Savva, Petros Petrou, Danica Galešić Ljubanović
Publikováno v:
Matrix Biology Plus, Vol 9, Iss, Pp 100053-(2021)
Matrix Biology Plus
Matrix Biology Plus
Alport syndrome (AS) is a severe inherited glomerulopathy caused by mutations in the genes encoding the α-chains of type-IV collagen, the most abundant component of the extracellular glomerular basement membrane (GBM). Currently most AS mouse models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9dede0573d325297111c28240dbf66d
http://www.sciencedirect.com/science/article/pii/S259002852030034X
http://www.sciencedirect.com/science/article/pii/S259002852030034X
Autor:
Mitchell J. de Souza, Matthew P. Hardy, Martin J. Pearse, Kim G. Lieu, Saw Yen Ow, Martin O. Spycher, Anup G. Nair, Michael J. Wilson, Jason Simmonds, Yun Dai, Sandra Wymann, Adrian Zuercher, Anna Schnell, Con Panousis, Rebecca E. Butcher, Glenn A. Powers, Marcel Mischnik, Tony Rowe, Genevieve Martin-Roussety, Adriana Baz Morelli, Helen Cao, David Leong, Shirley Taylor
Publikováno v:
The Journal of Biological Chemistry
Human complement receptor 1 (HuCR1) is a pivotal regulator of complement activity, acting on all three complement pathways as a membrane-bound receptor of C3b/C4b, C3/C5 convertase decay accelerator, and cofactor for factor I-mediated cleavage of C3b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605c43f8a6fc70ffcd57fb8866f643b1
https://doi.org/10.1074/jbc.ra120.016127
https://doi.org/10.1074/jbc.ra120.016127
Autor:
Billy G. Hudson, Ryan Bauer, Jarrod A. Smith, Sergey Ivanov, Paul A. Voziyan, Sergei P. Boudko, Sergei V. Chetyrkin
Publikováno v:
The Journal of Biological Chemistry
Our recent work identified a genetic variant of the α345 hexamer of the collagen IV scaffold that is present in patients with glomerular basement membrane diseases, Goodpasture's disease (GP) and Alport syndrome (AS), and phenocopies of AS in knock-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f16cd9d5f41724d2208df598a6a4ce
https://doi.org/10.1016/j.jbc.2021.100591
https://doi.org/10.1016/j.jbc.2021.100591
Autor:
George Haddad, Charles D. Pusey, Agnes B. Fogo, Dale R. Abrahamson, Rudolf P. Wüthrich, Clifford E. Kashtan, Alicia Simmons, Paul A. Voziyan, Fernando C. Fervenza, Sergei P. Boudko, Timo Wagner, Zhao Wei Cui, A. Richard Kitching, Raymond C. Harris, Eric Delpire, Andreas D. Kistler, Johan M. Lorenzen, Ming-Hui Zhao, Aaron L. Fidler, Sergei V. Chetyrkin, Ariana Gaspert, Carsten Bergmann, Oliver Gross, Billy G. Hudson, Maik Grohmann, Marten Segelmark, Harald Seeger, Elena Pokidysheva, Stephen P. McAdoo, Vadim Pedchenko
Publikováno v:
The Journal of Biological Chemistry
Diseases of the glomerular basement membrane (GBM), such as Goodpasture’s disease (GP) and Alport syndrome (AS), are a major cause of chronic kidney failure and an unmet medical need. Collagen IVα345 is an important architectural element of the GB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed717b2a810710cfdf2e9dee7466f10
https://doi.org/10.1016/j.jbc.2021.100590
https://doi.org/10.1016/j.jbc.2021.100590
Publikováno v:
Biochemical Journal
The kidney is widely regarded as an organ without regenerative abilities. However, in recent years this dogma has been challenged on the basis of observations of kidney recovery following acute injury, and the identification of renal populations that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147d0b341dead042342b6d24fad68865
https://doi.org/10.1042/bj20120176
https://doi.org/10.1042/bj20120176
Autor:
Anupam Agarwal, Balu K. Chacko, Kurt R. Zinn, Anup Srivastava, Balaraman Kalyanaraman, Yaozu Ye, Michelle S. Johnson, Elena Ulasova, Michael P. Murphy, Colin Reily, Victor M. Darley-Usmar
Publikováno v:
Biochemical Journal
Mitochondrial production of ROS (reactive oxygen species) is thought to be associated with the cellular damage resulting from chronic exposure to high glucose in long-term diabetic patients. We hypothesized that a mitochondria-targeted antioxidant wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b2011de91060723cc6eb5c7ac6b2a6
https://doi.org/10.1042/bj20100308
https://doi.org/10.1042/bj20100308