Zobrazeno 1 - 10
of 278
pro vyhledávání: '"GAT1"'
Autor:
Kazuyuki Fukushima, Hiroyuki Higashiyama, Yuji Kazuta, Keisuke Hashimoto, Naoto Watanabe, Yoshiaki Furuya, Yoshimasa Ito, Ting Wu, Takashi Kosasa, Delia M. Talos, Yeri Song, Nicholas S. Roberts, Frances E. Jensen, Takahisa Hanada, Katsutoshi Ido
Publikováno v:
Epilepsia Open, Vol 8, Iss 3, Pp 834-845 (2023)
Abstract Objective As of 2022, 36 anti‐seizure medications (ASMs) have been licensed for the treatment of epilepsy, however, adverse effects (AEs) are commonly reported. Therefore, ASMs with a wide margin between therapeutic effects and AEs are pre
Externí odkaz:
https://doaj.org/article/f701ca4aa9704aca88c101bf7dd510b7
Autor:
Manan Bhatt, Laure Gauthier-Manuel, Erika Lazzarin, Rocco Zerlotti, Christine Ziegler, Andre Bazzone, Thomas Stockner, Elena Bossi
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system (CNS). Its homeostasis is maintained by neuronal and glial GABA transporters (GATs). The four GATs identified in humans are GAT1 (SLC6A1), GAT2 (SLC6
Externí odkaz:
https://doaj.org/article/122f346d4f684060bcd6969a55da141f
Autor:
Kimberly Goodspeed, Lindsay R. Mosca, Nicole C. Weitzel, Kyle Horning, Elijah W. Simon, Anna C. Pfalzer, Maya Xia, Katherine Langer, Amber Freed, Megan Bone, Maria Picone, Terry Jo V. Bichell
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
IntroductionSLC6A1 Neurodevelopmental Disorder (SLC6A1-NDD), first described in 2015, is a rare syndrome caused by a mutation in the SLC6A1 gene which encodes for the GABA Transporter 1 (GAT-1) protein. Epilepsy is one of the most common symptoms in
Externí odkaz:
https://doaj.org/article/045ab631c7d44f84b4a098cd24540ed2
Autor:
Wenqiang Xu, Yu Fang, Mingyang Ding, Yajing Ren, Xiangfeng Meng, Guanjun Chen, Weixin Zhang, Weifeng Liu
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The filamentous fungus Trichoderma reesei secretes large quantities of cellulases and hemicellulases that have found wide applications in industry. Compared with extensive studies on the mechanism controlling cellulase gene expression, less is known
Externí odkaz:
https://doaj.org/article/9dfe131a4d644d9f80cb25873c7a5cd3
Akademický článek
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Akademický článek
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Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 874-882 (2017)
The γ-aminobutyric acid (GABA) transporter 1 (GAT1) belongs to a family of Na+ and Cl−-coupled transport proteins and possesses 12 putative transmembrane domains. To perform structural analyses of the GAT1 protein, the GAT1/green fluorescent prote
Externí odkaz:
https://doaj.org/article/19dd6ce363944ceb9f5cb03ed12adc60
Autor:
Sadia Zafar, Ishrat Jabeen
Publikováno v:
PeerJ, Vol 7, p e6283 (2019)
Background The γ-aminobutyric acid (GABA) transporter GAT1 is involved in GABA transport across the biological membrane in and out of the synaptic cleft. The efficiency of this Na+ coupled GABA transport is regulated by an electrochemical gradient,
Externí odkaz:
https://doaj.org/article/95b7164a1e154b349ccc8ba48de14501
Autor:
Ya-Ping Wang, Lin Liu, Xue-Shan Wang, Kun-Qiang Hong, Li-Hua Zhang, Zhong-Guan Sun, Dong-Guang Xiao
Publikováno v:
Bioengineering, Vol 8, Iss 5, p 61 (2021)
Uncoordinated carbon-nitrogen ratio in raw materials will lead to excessive contents of higher alcohols in alcoholic beverages. The effect of GAT1 gene, the GATA transcription activator, on higher alcohol biosynthesis was investigated to clarify the
Externí odkaz:
https://doaj.org/article/82975f8cf81e4f809365ba1399b17c13
Autor:
Sadia Zafar, Ishrat Jabeen
Publikováno v:
Molecules, Vol 25, Iss 20, p 4745 (2020)
The human gamma aminobutyric acid transporter subtype 1 (hGAT1) located in the nerve terminals is known to catalyze the neuronal function by the electrogenic reuptake of γ-aminobutyric acid (GABA) with the co-transport of Na+ and Cl− ions. In the
Externí odkaz:
https://doaj.org/article/d4afa42306b3476494e2c661be8e79f8