Zobrazeno 1 - 10
of 104
pro vyhledávání: '"GARY A. QUAMME"'
Publikováno v:
Journal of Biological Chemistry. 283:33365-33374
Polyglutamine expansions of huntingtin protein are responsible for the Huntington neurological disorder. HIP14 protein has been shown to interact with huntingtin. HIP14 and a HIP14-like protein, HIP14L, with a 69% similarity reside in the Golgi and p
Publikováno v:
American Journal of Physiology-Cell Physiology. 295:C944-C953
We used microarray analysis to identify renal cell transcripts that were upregulated with low magnesium. One transcript, identified as NIPA2 (nonimprinted in Prader-Willi/Angelman syndrome) subtype 2, was increased over twofold relative to cells cult
Autor:
Gary A. Quamme
Publikováno v:
Current Opinion in Gastroenterology. 24:230-235
Recent identification and characterization of novel Mg transporters have clarified our understanding of intestinal magnesium absorption. The predominant Mg transporters include TRPM6 and TRPM7, members of the transient receptor potential melastatin f
Autor:
Angelia Goytain, Gary A. Quamme
Publikováno v:
American Journal of Physiology-Cell Physiology. 294:C495-C502
Magnesium is an essential metal, but few selective transporters have been identified at the molecular level. Microarray analysis was used to identify two similar transcripts that are upregulated with low extracellular Mg2+. The corresponding cDNAs en
Autor:
Hyung-Sub Kang, Yong-Geun Kwak, Chang-Woo Jeong, Jin-Shang Kim, Sang-Yeol Park, Gary A. Quamme, In-Shik Kim, Sung-Zoo Kim, Nam-Soo Kim, Shang-Jin Kim
Publikováno v:
Biochemical and Biophysical Research Communications. 341:742-748
Immunosuppressants such as cyclosporinA and FK506 (tacrolimus) are widely prescribed to treat numerous disorders and to treat organ transplant recipients. However, cyclosporine A and FK506 are both known to produce hypomagnesaemia. The mechanism of t
Autor:
Angela Goytain, Gary A. Quamme
Publikováno v:
Physiological Genomics. 22:382-389
We have begun to identify and characterize genes that are differentially expressed with low magnesium. One of these sequences conformed to the ancient conserved domain protein, ACDP2. Real-time RT-PCR of mRNA isolated from distal epithelial cells cul
Autor:
Angela Goytain, Gary A. Quamme
Publikováno v:
Physiological Genomics. 21:337-342
We have begun to identify and characterize genes that are differentially expressed with low magnesium. One of these sequences conformed to the solute carrier SLC41A1. Real-time RT-PCR of RNA isolated from renal distal tubule epithelial [mouse distal
Autor:
Angela Goytain, Gary A. Quamme
Publikováno v:
Biochemical and Biophysical Research Communications. 330:701-705
We have recently demonstrated that the human solute carrier, SLC41A1, is a Mg 2+ transporter that is regulated by extracellular magnesium. A BLAST search found a closely related protein encoded by SLC41A2 that may have related functional properties.
Publikováno v:
American Journal of Physiology-Renal Physiology. 281:F1141-F1147
tk;1Adenosine plays a role in the control of water and electrolyte reabsorption in the distal tubule. As the distal convoluted tubule is important in the regulation of renal Mg2+ balance, we determined the effects of adenosine on cellular Mg2+ uptake
Publikováno v:
American Journal of Physiology-Renal Physiology. 281:F833-F840
First published July 12, 2001; 10.1152/ajprenal.00349.2001.—Nucleotides have diverse effects on water and electrolyte reabsorption within the distal tubule of the nephron. As the distal tubule is important in control of renal Mg2+balance, we determ