Impairment of T immunoregulatory activities in the induction of antibody specific response in aged humans

Autor: Maria Gallitelli, Garofalo Ar, Salvatore Antonaci, Emilio Jirillo, Lorenzo Bonomo

Publikováno v: Mechanisms of Ageing and Development. 30:251-259

T helper (Th) and T suppressor (Ts) functions on the induction of specific antibody response have been studied in 80 aged individuals by means of a plaque-forming cell assay. Of the subjects 45.2% exhibited a reduction of Ts activity on Ig production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff62eefc0f10c91b2c312cb7018a2045
https://doi.org/10.1016/0047-6374(85)90115-0

Regulatory effects mediated by OKT8+ subsets on B cell response in the elderly

Autor: Lorenzo Bonomo, Emilio Jirillo, Salvatore Antonaci, Maria Gallitelli, Garofalo Ar

Publikováno v: Mechanisms of Ageing and Development. 41:115-124

The B cell responsiveness mediated by T cells has been evaluated in 50 aged donors by using a Pokeweed mitogen (PWM)-driven differentiation system. Peripheral blood mononuclear cells (PBMC) from aged donors exhibited a lower plaque-forming cell (PFC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9994e56f163fbe02a1df5332dae301
https://doi.org/10.1016/0047-6374(87)90056-x

Non-specific immunity in aging: deficiency of monocyte and polymorphonuclear cell-mediated functions

Autor: Emilio Jirillo, Maria Teresa Ventura, Salvatore Antonaci, Lorenzo Bonomo, Garofalo Ar

Publikováno v: Mechanisms of ageing and development. 24(3)

Peripheral blood monocytes obtained from 55 aged donors were evaluated for their chemotactic and phagocytic capacity. In the same subjects, polymorphonuclear cell-mediated functions were studied by chemotaxis, phagocytosis, nylon fiber adherence and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40159a89fdcdd05594e0b963d0438f72
https://pubmed.ncbi.nlm.nih.gov/6717097

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Genomics, epigenomics and pharmacogenomics of familial hypercholesterolemia (FHBGEP): A study protocol.

Autor: Borges JB; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: jessica.bassani.borges@gmail.com., Oliveira VF; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: fo.victor@hotmail.com., Ferreira GM; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: glauciom.ferreira@gmail.com., Los B; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: brunalos17@gmail.com., Barbosa TKAA; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: thais.almendros@gmail.com., Marçal EDSR; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: elisangela.idpc@gmail.com., Dagli-Hernandez C; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: carolina.dagli@gmail.com., de Freitas RCC; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: renata_karoline@hotmail.com., Bortolin RH; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: raulhbortolin@yahoo.com.br., Mori AA; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: augusto.akira.mori@usp.br., Hirata TDC; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: thiagodch@gmail.com., Nakaya HTI; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: hnakaya@usp.br., Bastos GM; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil; Real e Benemerita Associação Portuguesa de Beneficiência, Sao Paulo, Brazil. Electronic address: gimebastos@gmail.com., Thurow HS; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: thurow.hs@gmail.com., Gonçalves RM; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: rodrigomg@gmail.com., Araujo DB; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: dbaraujo@gmail.com., Zatz HP; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: hpzatz@gmail.com., Bertolami A; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: adriana@cardiologiabertolami.com., Faludi AA; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: aaf.2312@gmail.com., Bertolami MC; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: bertolami@uol.com.br., Sousa AGMR; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: amandars@cardiol.br., França JÍD; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: jitalo@lee.dante.br., Jannes CE; Heart Institute, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: cejannes@hotmail.com., Pereira ADC; Heart Institute, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: acplbmpereira@gmail.com., Nakazone MA; Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, Brazil. Electronic address: naka_med@yahoo.com., Souza DRS; Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, Brazil. Electronic address: doroteiasouza@yahoo.com., Carmo TS; Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, Brazil. Electronic address: tay.scarmo@gmail.com., Sampaio MF; Real e Benemerita Associação Portuguesa de Beneficiência, Sao Paulo, Brazil. Electronic address: msampaio@cardiol.br., Gorjão R; Cruzeiro do Sul University, Sao Paulo, Brazil. Electronic address: renata.gorjao@cruzeirodosul.edu.br., Pithon-Curi TC; Cruzeiro do Sul University, Sao Paulo, Brazil. Electronic address: tania.pithon-curi@cruzeirodosul.edu.br., Moriel P; Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, Brazil. Electronic address: morielpatricia@gmail.com., Silbiger VN; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Brazil. Electronic address: viviansilbiger@hotmail.com., Luchessi AD; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Brazil. Electronic address: andre.luchessi@outlook.com., de Araújo JNG; Northeast Biotechnology Network (RENORBIO), Graduate Program in Biotechnology, Federal University of Rio Grande do Norte, Natal, Brazil. Electronic address: jessnaysub@hotmail.com., Naslavsky MS; Human Genome and Stem-Cell Research Center, Biosciences Institute, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: mnaslavsky@gmail.com., Wang JYT; Human Genome and Stem-Cell Research Center, Biosciences Institute, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: jaqueytw@gmail.com., Kronenberger T; Department of Internal Medicine VIII, University Hospital Tübingen, Tübingen, Germany. Electronic address: kronenberger7@gmail.com., Cerda A; Center of Excellence in Translational Medicine, BIOREN, Department of Basic Sciences, Universidad de La Frontera, Temuco, Chile. Electronic address: alvaro.cerda@ufrontera.cl., Lin-Wang HT; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: pesquisalin@yahoo.com.br., Garofalo AR; Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil. Electronic address: adrianaregarofalo@gmail.com., Fajardo CM; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: cris.mf01@gmail.com., Hirata RDC; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: rosariohirata@usp.br., Hirata MH; School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: mhhirata@usp.br.

Publikováno v: Research in social & administrative pharmacy : RSAP [Res Social Adm Pharm] 2021 Jul; Vol. 17 (7), pp. 1347-1355. Date of Electronic Publication: 2020 Oct 29.