Zobrazeno 1 - 10
of 1 259
pro vyhledávání: '"GARETH WILLIAMS"'
Autor:
Morag A. Lewis, Maria Lachgar-Ruiz, Francesca Di Domenico, Graham Duddy, Jing Chen, Sergio Fernandez, Matias Morin, Gareth Williams, Miguel Angel Moreno Pelayo, Karen P. Steel
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Progressive hearing loss is a common problem in the human population with no effective therapeutics currently available. However, it has a strong genetic contribution, and investigating the genes and regulatory interactions underl
Externí odkaz:
https://doaj.org/article/18ebda7be878464080ab6f75b1462e0e
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 1066 (2024)
Fibres in the micro- and nanometre scale are suited to a broad range of applications, including drug delivery and tissue engineering. Electrospinning is the manufacturing method of choice, but it has some limitations. Novel pressure-driven fibre-form
Externí odkaz:
https://doaj.org/article/6d174e88f9b24158b6ce01a4133ae6e8
Autor:
Pankaj Garg, Wasim Javed, Hosamadin Assadi, Samer Alabed, Ciaran Grafton-Clarke, Andrew J Swift, Gareth Williams, Abdallah Al-Mohammad, Chris Sawh, Vassilios S Vassiliou, Mohammed Y Khanji, Fabrizio Ricci, John P Greenwood, Sven Plein, Peter Swoboda
Publikováno v:
BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Objective To investigate whether left atrial (LA) volume and left ventricular filling pressure (LVFP) assessed by cardiovascular magnetic resonance (CMR) change during adenosine delivered myocardial hyperaemia as part of a first-pass stress
Externí odkaz:
https://doaj.org/article/51eaadac97cf46898615ec8760d917f7
Autor:
Thomas Rhys Evans, Calvin Burns, Ryan Essex, Gina Finnerty, Ella Hatton, Andrew James Clements, Genevieve Breau, Francis Quinn, Helen Elliott, Lorraine D. Smith, Barry Matthews, Kath Jennings, Jodie Crossman, Gareth Williams, Denise Miller, Benjamin Harold, Philip Gurnett, Lee Jagodzinski, Julie Smith, Wendy Milligan, Marianne Markowski, Peter Collins, Yuki Yoshimatsu, Jordi Margalef Turull, Mark Colpus, Mark L. Dayson, Sharon Weldon
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionDebriefings give healthcare workers voice through the opportunity to discuss unanticipated or difficult events and recommend changes. The typical goal of routine debriefings has been to improve clinical outcomes by learning through discus
Externí odkaz:
https://doaj.org/article/91c565f271ef45489b91b225deb0ab31
Autor:
Rebecca C. Gosling, Gareth Williams, Abdulaziz Al Baraikan, Samer Alabed, Eylem Levelt, Amrit Chowdhary, Peter P. Swoboda, Ian Halliday, D. Rodney Hose, Julian P. Gunn, John P. Greenwood, Sven Plein, Andrew J. Swift, James M. Wild, Pankaj Garg, Paul D. Morris
Publikováno v:
Cardiology Research and Practice, Vol 2023 (2023)
Background. Ischaemia with nonobstructive coronary arteries is most commonly caused by coronary microvascular dysfunction but remains difficult to diagnose without invasive testing. Myocardial blood flow (MBF) can be quantified noninvasively on stres
Externí odkaz:
https://doaj.org/article/d9164417667142e3888ceca3915eedf5
Publikováno v:
Frontiers in Psychology, Vol 13 (2022)
IntroductionThe change in Chinese fertility policy brings new challenges and considerations for children’s health outcomes; however, very little is known about the interaction between siblings, family socioeconomic status (SES), and neurodevelopmen
Externí odkaz:
https://doaj.org/article/cb4bb316fc4a4f50b03fa7f8e8a4b243
Autor:
Richard Killick, Christina Elliott, Elena Ribe, Martin Broadstock, Clive Ballard, Dag Aarsland, Gareth Williams
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11219 (2023)
The pan Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor fasudil acts as a vasodilator and has been used as a medication for post-cerebral stroke for the past 29 years in Japan and China. More recently, based on the involvement o
Externí odkaz:
https://doaj.org/article/6ef281694b6e49188979fd046f1e6899
Autor:
Abdulaziz Al Baraikan, Krzysztof Czechowicz, Paul D. Morris, Ian Halliday, Rebecca C. Gosling, Julian P. Gunn, Andrew J. Narracott, Gareth Williams, Pankaj Garg, Maciej Malawski, Frans van de Vosse, Angela Lungu, Dan Rafiroiu, David Rodney Hose
Publikováno v:
Fluids, Vol 8, Iss 5, p 159 (2023)
Acting upon clinical patient data, acquired in the pathway of percutaneous intervention, we deploy hierarchical, multi-stage, data-handling protocols and interacting low- and high-order mathematical models (chamber elastance, state-space system and C
Externí odkaz:
https://doaj.org/article/60af9157f2b847768b7ff602f26e11ae
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0245817 (2022)
The standard treatment for glioblastoma involves a combination of surgery, radiation and chemotherapy but have limited impact on survival. The exponential increase in targeted agents directed at pivotal oncogenic pathways now provide new therapeutic
Externí odkaz:
https://doaj.org/article/d07d76b81cdb4578a214ceae321c8ed6
Autor:
Marco Loddo, Keeda-Marie Hardisty, Alexander Llewelyn, Tiffany Haddow, Robert Thatcher, Gareth Williams
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0246778 (2022)
Oncogenic fusions represent compelling druggable targets in solid tumours highlighted by the recent site agnostic FDA approval of larotrectinib for NTRK rearrangements. However screening for fusions in routinely processed tissue samples is constraine
Externí odkaz:
https://doaj.org/article/ff44c4eca87a435cbd7166f80343403a