Výsledky vyhledávání - "GAP Proteins"

Rho-Signalgebung in der Tumorentstehung und -progression

Autor: Monilola A. Olayioye, Janina Hendrick, Bettina Noll

Publikováno v: BIOspektrum. 22:369-372

Metastatic cancers are characterized by uncontrolled cell proliferation and tissue invasion, processes controlled by small Rho GTPases, the activation of which is regulated by GEF and GAP proteins. Deleted in liver cancer (DLC) proteins are such Rho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::583ee8e4956e65c2056151e745b2e60b
https://doi.org/10.1007/s12268-016-0700-5

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A potential Rho GEF and Rac GAP for coupled Rac and Rho cycles during mesenchymal-to-epithelial-like transitions

Autor: André Le Bivic, Christopher P. Toret

Publikováno v: Small GTPases
Small GTPases, Taylor & Francis, 2018, pp.1-7. ⟨10.1080/21541248.2018.1502592⟩
Small GTPases, 2021, 12 (1), pp.13-19. ⟨10.1080/21541248.2018.1502592⟩
Small GTPases, 2018, pp.1-7. ⟨10.1080/21541248.2018.1502592⟩
Small GTPases, Taylor & Francis, 2021, 12 (1), pp.13-19. ⟨10.1080/21541248.2018.1502592⟩

International audience; The leading edge-to-cadherin contact transitions that occur during metazoan developmental processes and disease states require fine coordination of Rac and Rho pathways. Recently the elmo-mbc complex, a Rac GEF and RhoGAP19D,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6c2ec6777e4e242a11c90912079be9
https://hal.archives-ouvertes.fr/hal-01973878

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A GAP that Divides

Autor: Angika Basant, Michael Glotzer

Publikováno v: F1000Research

Cytokinesis in metazoan cells is mediated by an actomyosin-based contractile ring that assembles in response to activation of the small GTPase RhoA. The guanine nucleotide exchange factor that activates RhoA during cytokinesis, ECT-2, is highly regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9cddf8ceea27c7b913f12fec121f26
http://europepmc.org/articles/PMC5627578

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Ras activation revisited

Autor: Ignacio Rubio, Julian Downward

Publikováno v: Scopus-Elsevier

other major group of regulatory proteins for Ras, have been mostly attributed a rather passive role related to termination of Ras-elicited signals. In this review we have attempted to summarise our current understanding of the reactions that lead to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5339ffcd20c49639748721d81f770399
https://doi.org/10.1002/1615-4061(200101)1:1+<11::aid-sita11>3.0.co

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Arf GAPs: gatekeepers of vesicle generation

Autor: Paul A. Randazzo, Yoko Shiba, Anne Spang

Publikováno v: FEBS letters

Arf GAP proteins are a versatile and diverse group of proteins. They control the activity of the GTP-binding proteins of the ARF family by inducing the hydrolysis of GTP that is bound to Arf proteins. The best-studied role of Arf GAPs is in intracell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d38364eb2fe76c5c17a908a28ec9e31
https://pubmed.ncbi.nlm.nih.gov/20394747

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Zebra patterns in fly embryos: activation of stripes or repression of interstripes?

Autor: Sean B. Carroll

Publikováno v: Cell. 60(1)

Like Gould's zebra, the striped embryo can be viewed as a pattern of both interstripe repression and stripe activation. A growing body of evidence suggests that both processes are at work in regulating pair-rule gene expression. Certain genes, such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1a59d8ebbcb9443f5d5b908aa25265
https://pubmed.ncbi.nlm.nih.gov/2403844

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