Zobrazeno 1 - 10
of 61
pro vyhledávání: '"GAP (GTPase-activating protein)"'
Autor:
Shruthi Sudarshan, Manoj Kumar, Punit Kaur, Atin Kumar, Sethuraman G., Savita Sapra, Sheffali Gulati, Neerja Gupta, Madhulika Kabra, Madhumita Roy Chowdhury
Publikováno v:
BMC Medical Genetics, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Mutations in TSC1 or TSC2 gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by the formation of non-malignant hamartomas in multiple vital organs. TSC1 and TSC2 gene products form TSC hetero
Externí odkaz:
https://doaj.org/article/5ebd69bf72a54b7ba23669d521fdf941
Autor:
Kasper Hoebe, Shrinivas Bishu, John Y. Kao, Varsha Ganesan, Ankit Sharma, Yanfen Yang, Chang Zeng, Rodney D. Newberry, Sahiti Marella, Simon P. Hogan, Philip D. King, Ariel Munitz, Jazib Uddin, Taeko K. Noah, Lee A. Denson, Andrew R. Patterson, Simone Vanoni, Lisa Waggoner, Senad Divanovic, Paul S. Foster, Michael J. Rosen, S. M. S. Tomar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1479-1502 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1479-1502 (2021)
Background & Aims CD4+ T cells are regulated by activating and inhibitory cues, and dysregulation of these proper regulatory inputs predisposes these cells to aberrant inflammation and exacerbation of disease. We investigated the role of the inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bc9234d68120dd2171e099da6a99f4
http://europepmc.org/articles/PMC8531983
http://europepmc.org/articles/PMC8531983
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 569-581 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Autophagy, defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes, plays a significant role in the quality control of macromolecules and organelles. Since protein kinases are integral to the autophagy proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e45bf1ac401222740c4f8e78dae670
http://www.sciencedirect.com/science/article/pii/S221138351930276X
http://www.sciencedirect.com/science/article/pii/S221138351930276X
Autor:
Christoph Wittich, Claus A. M. Seidel, Radovan Dvorsky, Soheila Rezaei Adariani, Farhad Bazgir, Ehsan Amin, Mohammad Reza Ahmadian, Neda S. Kazemein Jasemi
Publikováno v:
The Journal of Biological Chemistry
RAS effectors specifically interact with GTP-bound RAS proteins to link extracellular signals to downstream signaling pathways. These interactions rely on two types of domains, called RAS-binding (RB) and RAS association (RA) domains, which share com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c908bf66f01ab88e26b2531338812873
http://europepmc.org/articles/PMC8163975
http://europepmc.org/articles/PMC8163975
Publikováno v:
The Journal of Biological Chemistry
During signal transduction, the G protein, Gαq, binds and activates phospholipase C-β isozymes. Several diseases have been shown to manifest upon constitutively activating mutation of Gαq, such as uveal melanoma. Therefore, methods are needed to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b312183ea3757d6df7e63b851043a207
https://pubmed.ncbi.nlm.nih.gov/34715131
https://pubmed.ncbi.nlm.nih.gov/34715131
Publikováno v:
The Journal of Biological Chemistry
Rho/Ras family small GTPases are known to regulate numerous cellular processes, including cytoskeletal reorganization, cell proliferation, and cell differentiation. These processes are also controlled by Ca2+, and consequently, cross talk between the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140bda14014405287b83abe6cfc634b1
http://europepmc.org/articles/PMC7949103
http://europepmc.org/articles/PMC7949103
Autor:
Shah, Seema, Brock, Ethan J., Jackson, Ryan M., Ji, Kyungmin, Boerner, Julie L., Sloane, Bonnie F., Mattingly, Raymond R.
Publikováno v:
Neoplasia (New York, N.Y.)
Diagnosis of breast ductal carcinoma in situ (DCIS) presents a challenge since we cannot yet distinguish those cases that would remain indolent and not require aggressive treatment from cases that may progress to invasive ductal cancer (IDC). The pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8109f7cc0b354221a67fbb885d910687
http://europepmc.org/articles/PMC6106701
http://europepmc.org/articles/PMC6106701
Autor:
Lyugao Qin, Tomonori Kaneko, Xuguang Liu, Courtney Voss, Shawn S.-C. Li, Xuan Cao, Guoping Wang
Publikováno v:
Paediatrics Publications
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Cell migration is an essential physiological process, and aberrant migration of epithelial cells underlies many pathological conditions. However, the molecular mechanisms governing cell migration are not fully understood. We report here that growth f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d321b1dfd772811b3d34652c44e6e5
https://doi.org/10.1016/j.jbc.2021.101161
https://doi.org/10.1016/j.jbc.2021.101161
Publikováno v:
The Journal of Biological Chemistry
NADPH oxidase 2 (NOX2) produces the superoxide anion radical (O2−), which has functions in both cell signaling and immune defense. NOX2 is a multimeric-protein complex consisting of several protein subunits including the GTPase Rac. NOX2 uniquely f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1acf3cfb40506c59e24d46a27b8069
https://doi.org/10.1016/j.jbc.2021.100982
https://doi.org/10.1016/j.jbc.2021.100982
Autor:
Ward, Matthew, Iskratsch, Thomas
Publikováno v:
Biochimica et Biophysica Acta. Molecular Cell Research
The composition and the stiffness of cardiac microenvironment change during development and/or in heart disease. Cardiomyocytes (CMs) and their progenitors sense these changes, which decides over the cell fate and can trigger CM (progenitor) prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4179d4eefebf105245222732b8cb9ce5
http://europepmc.org/articles/PMC7042712
http://europepmc.org/articles/PMC7042712