Zobrazeno 1 - 10
of 473
pro vyhledávání: '"GABAergic Interneuron"'
Publikováno v:
Neurobiology of Disease, Vol 203, Iss , Pp 106737- (2024)
Parvalbumin-positive (PV+) GABAergic interneurons in the dentate gyrus provide powerful perisomatic inhibition of dentate granule cells (DGCs) to prevent overexcitation and maintain the stability of dentate gyrus circuits. Most dentate PV+ interneuro
Externí odkaz:
https://doaj.org/article/bcd3309bbe7d4b9eb6d86e8797b69ef9
Autor:
Yuka Shirakawa, Heng Li, Yuki Inoue, Hitomi Izumi, Yoshimi Kaga, Yu-ichi Goto, Ken Inoue, Masumi Inagaki
Publikováno v:
IBRO Neuroscience Reports, Vol 16, Iss , Pp 67-77 (2024)
The homozygous Bronx waltzer (bv) mouse, which shows hearing impairment, also exhibits anxiety accompanied by a reduction in cortical parvalbumin (PV)-positive GABAergic interneurons. Recently, a mutation in splicing factor Ser/Arg repetitive matrix
Externí odkaz:
https://doaj.org/article/9c5f8e64c1b4417a8e422f050ea28339
Autor:
Ricardo Raudales, Gukhan Kim, Sean M Kelly, Joshua Hatfield, Wuqiang Guan, Shengli Zhao, Anirban Paul, Yongjun Qian, Bo Li, Z Josh Huang
Publikováno v:
eLife, Vol 13 (2024)
Axo-axonic cells (AACs), also called chandelier cells (ChCs) in the cerebral cortex, are the most distinctive type of GABAergic interneurons described in the neocortex, hippocampus, and basolateral amygdala (BLA). AACs selectively innervate glutamate
Externí odkaz:
https://doaj.org/article/9f18dd07bd2040d2ab79afe21cb0e22d
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-20 (2023)
Abstract Kainate type glutamate receptors (KARs) are strongly expressed in GABAergic interneurons and have the capability of modulating their functions via ionotropic and G-protein coupled mechanisms. GABAergic interneurons are critical for generatio
Externí odkaz:
https://doaj.org/article/2b0e1d58157b415c817fb1a95e40c260
Autor:
Arena Manning, Victor Han, Alexa Stephens, Rose Wang, Nicholas Bush, Michelle Bard, Jan M. Ramirez, Franck Kalume
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106288- (2023)
Mutations in the NADH dehydrogenase (ubiquinone reductase) iron‑sulfur protein 4 (NDUFS4) gene, which encodes for a key structural subunit of the OXFOS complex I (CI), lead to the most common form of mitochondrial disease in children known as Leigh
Externí odkaz:
https://doaj.org/article/da24b01d7ecd4de28f1662b36f291cd6
Akademický článek
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Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 15 (2023)
Although the hippocampus is generally considered a cognitive center for spatial representation, learning, and memory, increasing evidence supports its roles in regulating locomotion. However, the neuronal mechanisms of the hippocampal regulation of l
Externí odkaz:
https://doaj.org/article/55f56a8c44eb4318bed4bd4c18e29297
Autor:
Christopher Daniel Morrone, Aaron Yenhsin Lai, Jossana Bishay, Mary Elizabeth Hill, JoAnne McLaurin
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-22 (2022)
Abstract Background Patient-to-patient variability in the degree to which β-amyloid, tau and neurodegeneration impact cognitive decline in Alzheimer’s disease (AD) complicates disease modeling and treatment. However, the underlying mechanisms lead
Externí odkaz:
https://doaj.org/article/31c9b4e8d4294f769bec737ace21dcaf
Autor:
Sanjay Singh, Lisa Topolnik
Publikováno v:
Frontiers in Neural Circuits, Vol 17 (2023)
Fear learning and memory rely on dynamic interactions between the excitatory and inhibitory neuronal populations that make up the prefrontal cortical, amygdala, and hippocampal circuits. Whereas inhibition of excitatory principal cells (PCs) by GABAe
Externí odkaz:
https://doaj.org/article/4a2743c33b7c4d54bf51499e1095a052
Autor:
Kaiqin Lu, Yuan Hong, Mengdan Tao, Luping Shen, Zhilong Zheng, Kaiheng Fang, Fang Yuan, Min Xu, Chun Wang, Dongya Zhu, Xing Guo, Yan Liu
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract Major depressive disorder with suicide behavior (sMDD) is a severe mood disorder, bringing tremendous burden to family and society. Although reduced gamma amino butyric acid (GABA) level has been observed in postmortem tissues of sMDD patien
Externí odkaz:
https://doaj.org/article/1b33819103084df9bc39368f626619b1