Zobrazeno 1 - 10
of 21 521
pro vyhledávání: '"GABAa receptor"'
Publikováno v:
Asian Pacific Journal of Tropical Medicine, Vol 17, Iss 11, Pp 481-490 (2024)
The use of insecticides remain the most effective vector control approach for mosquito borne diseases like malaria, dengue fever, chikungunya, and Zika virus disease; however, their increasing resistance has complicated the management. Mutations in k
Externí odkaz:
https://doaj.org/article/9796ebb0d24343ac9a7c0bc0d1d1d13c
Autor:
Zihan Wang, Haoran Zheng, Hui Yang, Huifang Song, Jingjing Lian, Chao Peng, Han Wang, Hanbo Zhang, Yulin Zheng, Qiufeng Wang, Lan Lan, Guifang Duan, Lin Ma, Xiaodong Peng, Zhuo Huang
Publikováno v:
Fundamental Research, Vol 4, Iss 6, Pp 1357-1364 (2024)
The approval of Epidiolex, an anti-epileptic drug containing cannabidiol (CBD) as its active component, has brought hope to patients with refractory epilepsy. However, the anti-seizure effect of full-spectrum hemp extract (HE), a CBD-enriched hemp oi
Externí odkaz:
https://doaj.org/article/aa49db54001d477f89f9e92be1990d6f
Autor:
Yoshihiko Kosaki, Daisuke Nishizawa, Junko Hasegawa, Kaori Yoshida, Kazutaka Ikeda, Tatsuya Ichinohe
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Midazolam is widely used for intravenous sedation. However, wide interindividual variability is seen in the sensitivity to midazolam. The association between genetic factors and interindividual differences in midazolam sensitivity remains un
Externí odkaz:
https://doaj.org/article/8349feeda5734ba28d8dbb6031cb3555
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol Volume 20, Pp 1781-1796 (2024)
Juan Qiao,1,2 Shiwan Tao,2 Yurong Sun,3,4 Jiabo Shi,2,5 Yu Chen,2,5 Shui Tian,3,4 Zhijian Yao,2,5 Qing Lu3,4 1Department of Psychology, Xuzhou East Hospital Affiliated to Xuzhou Medical University, Xuzhou, People’s Republic of China; 2Department of
Externí odkaz:
https://doaj.org/article/029f3c2ff91845809d02a56239e972e6
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
The expression of GABAARs goes through large scale, evolutionarily conserved changes through the early postnatal period. While these changes have been well-studied in brain regions such as the hippocampus and sensory cortices, less is known about ear
Externí odkaz:
https://doaj.org/article/0fdc87ffb8e0442cac090d189bc6579a
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Insomnia is the most common sleep disorder in which an individual has trouble falling or staying asleep. Chronic sleep loss interferes with daily functioning and adversely affects health. The main clinical drugs for insomnia are the positive alloster
Externí odkaz:
https://doaj.org/article/93de1b36b3db4b6489ea8afa34cda86c
Publikováno v:
Experimental Biology and Medicine, Vol 249 (2024)
Prolonged exposure to volatile anesthetics may raise the risk of developing cognitive impairment by acting on gamma-a Aminobutyric acid A receptors (GABAAR). The dentate gyrus plays an important role in the hippocampus and has a high potential for ne
Externí odkaz:
https://doaj.org/article/aa3dd532efd644de9db9725c9bf362f1
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit containing GABAA recepto
Externí odkaz:
https://doaj.org/article/42431302e7c843399a5a0d1659566016
Publikováno v:
Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)
Abstract Pain, a comorbidity of anxiety disorders, causes substantial clinical, social, and economic burdens. Emerging evidence suggests that propofol, the most commonly used general anesthetic, may regulate psychological disorders; however, its role
Externí odkaz:
https://doaj.org/article/5c7379d4da684a2f87ac6678f75ca598
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
IntroductionStress and trauma are significant risk factors for many neuropsychiatric disorders and diseases, including anxiety disorders. Stress-induced anxiety symptoms have been attributed to enhanced excitability in circuits controlling fear, anxi
Externí odkaz:
https://doaj.org/article/00ee864373c4445ab47446946296d706