Zobrazeno 1 - 10
of 2 013
pro vyhledávání: '"GABA transporter"'
Autor:
Nikita Shah, Ameya S. Kasture, Florian P. Fischer, Harald H. Sitte, Thomas Hummel, Sonja Sucic
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
As the first member of the solute carrier 6 (SLC6) protein family, the γ-aminobutyric acid (GABA) transporter 1 (GAT1, SLC6A1), plays a pivotal role in the uptake of GABA from the synaptic cleft into neurons and astrocytes. This process facilitates
Externí odkaz:
https://doaj.org/article/32a4d9eccf1a45ecadbc7b915b884790
Autor:
Nisha Gopal, Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A. Pfuetzner, Axel T. Brunger
Publikováno v:
Current Research in Physiology, Vol 7, Iss , Pp 100121- (2024)
Synaptic vesicles specific to inhibitory GABA-releasing neurons are critical for regulating neuronal excitability. To study the specific molecular composition, architecture, and function of inhibitory synaptic vesicles, we have developed a new method
Externí odkaz:
https://doaj.org/article/676dd94ef0024c84ac2e9b4e8b0a1e30
Autor:
Niels Knippenberg, Matthias Bauwens, Olaf Schijns, Govert Hoogland, Alexandru Florea, Kim Rijkers, Thomas J. Cleij, Kasper Eersels, Bart van Grinsven, Hanne Diliën
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-21 (2023)
Abstract By clearing GABA from the synaptic cleft, GABA transporters (GATs) play an essential role in inhibitory neurotransmission. Consequently, in vivo visualization of GATs can be a valuable diagnostic tool and biomarker for various psychiatric an
Externí odkaz:
https://doaj.org/article/b64430080ced41669b512618149e6f45
Publikováno v:
Cells, Vol 13, Iss 4, p 318 (2024)
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system (CNS). Most GABAergic neurons synthesize GABA from glutamate and release it in the synaptic cleft in the CNS. However, astrocytes can also synthesiz
Externí odkaz:
https://doaj.org/article/c100a2be20ea446f81ee161544eb6159
Autor:
Tiziana Romanazzi, Daniele Zanella, Manan Bhatt, Angela Di Iacovo, Aurelio Galli, Elena Bossi
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Synthesized in the liver from cholesterol, the bile acids (BAs) primary role is emulsifying fats to facilitate their absorption. BAs can cross the blood-brain barrier (BBB) and be synthesized in the brain. Recent evidence suggests a role for BAs in t
Externí odkaz:
https://doaj.org/article/c67a404e8fe5440f8027adfde41840e8
Autor:
Min-Yi Wu, Wen-Jun Zou, Pei Yu, Yuhua Yang, Shao-Jian Li, Qiang Liu, Jiatian Xie, Si-Qi Chen, Wei-Jye Lin, Yamei Tang
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 10, Pp 2253-2259 (2022)
Radiation therapy is a standard treatment for head and neck tumors. However, patients often exhibit cognitive impairments following radiation therapy. Previous studies have revealed that hippocampal dysfunction, specifically abnormal hippocampal neur
Externí odkaz:
https://doaj.org/article/3fd46700f7a84fbda2d36eb73af59fb9
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Rheumatoid arthritis (RA) is a highly disabling chronic autoimmune disease. Multiple factors contribute to the complex pathological process of RA, in which an abnormal autoimmune response, high survival of inflammatory cells, and excessive release of
Externí odkaz:
https://doaj.org/article/5c799dbac9e047168accc8f773884baa
Autor:
Ameya S. Kasture, Florian P. Fischer, Lisa Kunert, Melanie L. Burger, Alexander C. Burgstaller, Ali El-Kasaby, Thomas Hummel, Sonja Sucic
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
Mutations in the human γ-aminobutyric acid (GABA) transporter 1 (hGAT-1) can instigate myoclonic-atonic and other generalized epilepsies in the afflicted individuals. We systematically examined fifteen hGAT-1 disease variants, all of which dramatica
Externí odkaz:
https://doaj.org/article/4ffecd21f91c4448a6d11fb06eb3c27c
Autor:
Felicia Mermer, Sarah Poliquin, Shuizhen Zhou, Xiaodong Wang, Yifeng Ding, Fei Yin, Wangzhen Shen, Juexin Wang, Kathryn Rigsby, Dong Xu, Taralynn Mack, Gerald Nwosu, Carson Flamm, Matthew Stein, Jing-Qiong Kang
Publikováno v:
Neurobiology of Disease, Vol 172, Iss , Pp 105810- (2022)
Objective: Mutations in γ-aminobutyric acid (GABA) transporter 1 (GAT-1)-encoding SLC6A1 have been associated with myoclonic atonic epilepsy and other phenotypes. We determined the patho-mechanisms of the mutant GAT-1, in order to identify treatment
Externí odkaz:
https://doaj.org/article/d1f63b8a4f894bc59d7315bb22010afa
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