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Approaches to Structural Characterization of a Heteromeric GABA(A)R

Autor: Stevens, Alexander

Structural biology has become an important part of researching various diseases and drug development. In this thesis, I provide details on how I worked with approaches to structural characterization of a heteromeric GABA(A)R. These pentameric ligand

Externí odkaz: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-323235

The de novo missense mutation F224S in GABRB2, identified in epileptic encephalopathy and developmental delay, impairs GABA A R function.

Autor: Li PP; Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Zhou YY; Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Gao L; Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Lv JN; Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Xu SS; Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Zhao YW; Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Xu D; Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Huang R; Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Zhang X; Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China., Li P; Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, 250117 Jinan, Shandong, China., Fu X; Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China; Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, 250117 Jinan, Shandong, China., He Z; Department of Pediatric Rehabilitation, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: 217191@wzhealth.com.

Publikováno v: Neuroscience [Neuroscience] 2024 Aug 16; Vol. 553, pp. 172-184. Date of Electronic Publication: 2024 Jul 02.

Comparative Electroencephalographic Profile of a New Anesthetic and Anticonvulsant That Is Selective for the GABA A R Slow Receptor Subtype.

Autor: Maciver MB; From the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California., McCarren HS; US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland., Eagleman SL; From the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California., Davies FM; From the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California., Jahangir A; Department of Neurosurgery, Stanford University, Stanford, California., Pal D; Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan., Mashour GA; Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan., Bertaccini EJ; From the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California.; Department of Anesthesiology, Palo Alto VA Health Care System, Palo Alto, California.

Publikováno v: Anesthesia and analgesia [Anesth Analg] 2024 Oct 04. Date of Electronic Publication: 2024 Oct 04.

Synthesis and Receptor Binding Studies of α5 GABA A R Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders.

Autor: Sharmin, Dishary¹ (AUTHOR) dsharmin@uwm.edu, Mian, Md Yeunus¹ (AUTHOR), Marcotte, Michael² (AUTHOR), Prevot, Thomas D.^2,3 (AUTHOR), Sibille, Etienne^2,3,4 (AUTHOR), Witkin, Jeffrey M.^1,5 (AUTHOR), Cook, James M.¹ (AUTHOR) dsharmin@uwm.edu

Publikováno v: Molecules. Jun2023, Vol. 28 Issue 12, p4771. 37p.