OC-004 Thiopurine Induced Pancreatitis In Inflammatory Bowel Disease: Clinical Features And Genetic Determinants

Autor: GA Heap, A Singh, C Bewshea, MN Weedon, A Cole, T Creed, E Greig, P Irving, J Lindsay, J Mawdsley, Z Mazhar, T Orchard, D Reffitt, A Holden, T Ahmad

Publikováno v: Gut. 63:A2.2-A3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53fc70cc2eea235827318d9320a30ecc
https://doi.org/10.1136/gutjnl-2014-307263.4

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.

Autor: Sazonovs A; Genomics of Inflammation and Immunity Group, Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Stevens CR; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Venkataraman GR; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Yuan K; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Avila B; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Abreu MT; Crohn's and Colitis Center, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA., Ahmad T; Royal Devon and Exeter Hospital, Exeter, UK., Allez M; Hopital Saint-Louis, APHP, Universite de Paris, INSERM U1160, Paris, France., Ananthakrishnan AN; Division of Gastroenterology, Crohn's and Colitis Center, Massachusetts General Hospital, Boston, MA, USA., Atzmon G; Department for Human Biology, University of Haifa, Haifa, Israel.; Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY, USA., Baras A; Regeneron Genetics Center, Tarrytown, NY, USA., Barrett JC; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Barzilai N; Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.; The Institute for Aging Research, The Nathan Shock Center of Excellence in the Basic Biology of Aging and the Paul F. Glenn Center for the Biology of Human Aging Research at Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA., Beaugerie L; Gastroenterology Department, Sorbonne Universite, Saint Antoine Hospital, Paris, France., Beecham A; John P. Hussman Institute for Human Genomics, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA., Bernstein CN; University of Manitoba, Winnipeg, Manitoba, Canada., Bitton A; McGill University and McGill University Health Centre, Montreal, Quebec, Canada., Bokemeyer B; Department of Internal Medicine, University Medical Center Schleswig-Holstein, Kiel, Germany., Chan A; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Womens Hospital, Boston, MA, USA., Chung D; Massachusetts General Hospital, Boston, MA, USA., Cleynen I; Department of Human Genetics, KU Leuven, Leuven, Belgium., Cosnes J; Professeur Chef de Service chez APHP and Universite Paris-6, Paris, France., Cutler DJ; Department of Human Genetics, Emory University, Atlanta, GA, USA.; Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA., Daly A; Human Genetics Informatics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Damas OM; University of Miami, Miami, FL, USA., Datta LW; Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Dawany N; Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA., Devoto M; Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.; University of Rome Sapienza, Rome, Italy.; IRGB - CNR, Cagliari, Italy.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA., Dodge S; Genomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ellinghaus E; Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany., Fachal L; Genomics of Inflammation and Immunity Group, Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Farkkila M; Helsinki University Central Hospital, Helsinki, Finland., Faubion W; Mayo Clinic, Rochester, Rochester, MN, USA., Ferreira M; Regeneron Genetics Center, Tarrytown, NY, USA., Franchimont D; Erasme Hospital, ULB, Brussels, Belgium., Gabriel SB; Genomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ge T; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Georges M; University of Liège, ULG, Liège, Belgium., Gettler K; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Giri M; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Glaser B; Department of Endocrinology and Metabolism, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Goerg S; University Medical Center Schleswig-Holstein, Kiel, Germany., Goyette P; Research Center Montreal Heart Institute, Montreal, Quebec, Canada., Graham D; Infectious Disease and Microbiome Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA., Hämäläinen E; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland., Haritunians T; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA., Heap GA; Royal Devon and Exeter Hospital, Exeter, UK., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Hoeppner M; Christian-Albrechts-University of Kiel, Kiel, Germany., Horowitz JE; Regeneron Genetics Center, Tarrytown, NY, USA., Irving P; Department of Gastroenterology, Guys and Saint Thomas Hospital, London, UK.; School of Immunology and Microbial Sciences, Kings College London, London, UK., Iyer V; Human Genetics Informatics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Jalas C; Director of Genetic Resources and Services, Center for Rare Jewish Genetic Disorders, Bonei Olam, Brooklyn, NY, USA., Kelsen J; Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA., Khalili H; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA., Kirschner BS; Department of Gastroenterology, University of Chicago Medicine, Chicago, IL, USA., Kontula K; Department of Medicine, Helsinki University Hospital, and Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland., Koskela JT; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland., Kugathasan S; Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA., Kupcinskas J; Department of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania., Lamb CA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Laudes M; University Medical Center Schleswig-Holstein, Kiel, Germany., Lévesque C; Research Center Montreal Heart Institute, Montreal, Quebec, Canada., Levine AP; University College London, London, UK., Lewis JD; Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.; Crohn's and Colitis Foundation, New York, NY, USA., Liefferinckx C; Erasme Hospital, ULB, Brussels, Belgium., Loescher BS; Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany., Louis E; University of Liège, ULG, Liège, Belgium., Mansfield J; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., May S; Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany., McCauley JL; John P. Hussman Institute for Human Genomics, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA., Mengesha E; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA., Mni M; University of Liège, ULG, Liège, Belgium., Moayyedi P; McMaster University, Hamilton, Ontario, Canada., Moran CJ; Massachusetts General Hospital, Boston, MA, USA., Newberry RD; Washington University School of Medicine, St. Louis, MO, USA., O'Charoen S; Crohn's and Colitis Foundation, New York, NY, USA., Okou DT; Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.; Institut National de Sante Publique (INSP), Abidjan, Côte d'Ivoire., Oldenburg B; Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands., Ostrer H; Albert Einstein College of Medicine, Bronx, NY, USA., Palotie A; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Paquette J; Research Center Montreal Heart Institute, Montreal, Quebec, Canada., Pekow J; Department of Gastroenterology, University of Chicago Medicine, Chicago, IL, USA., Peter I; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Pierik MJ; Department of Gastroenterology and Hepatology, Maastricht University Medical Centre, Maastricht, The Netherlands., Ponsioen CY; Department of Gastroenterology and Hepatology, Amsterdam University Medical Centres, Amsterdam, The Netherlands., Pontikos N; University College London, London, UK., Prescott N; Department of Medical and Molecular Genetics, Kings College London, London, UK., Pulver AE; School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Rahmouni S; University of Liège, ULG, Liège, Belgium., Rice DL; Genomics of Inflammation and Immunity Group, Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Saavalainen P; Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland., Sands B; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sartor RB; Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Schiff ER; University College London, London, UK., Schreiber S; Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany., Schumm LP; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Segal AW; University College London, London, UK., Seksik P; Gastroenterology Department, Sorbonne Universite, Saint Antoine Hospital, Paris, France., Shawky R; IBD BioResource, NIHR BioResource, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Sheikh SZ; Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Silverberg MS; Mount Sinai Hospital, Toronto, Ontario, Canada., Simmons A; MRC Human Immunology Unit, NIHR Biomedical Research Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Skeiceviciene J; Department of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania., Sokol H; Gastroenterology Department, Sorbonne Universite, Saint Antoine Hospital, Paris, France., Solomonson M; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Somineni H; Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA., Sun D; Regeneron Genetics Center, Tarrytown, NY, USA., Targan S; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA., Turner D; Shaare Zedek Medical Center, Jerusalem, Israel., Uhlig HH; Translational Gastroenterology Unit and Biomedical Research Centre, Nuffield Department of Clinical Medicine, Experimental Medicine Division, University of Oxford, Oxford, UK.; Department of Pediatrics, John Radcliffe Hospital, Oxford, UK., van der Meulen AE; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Vermeire S; University Hospitals Leuven, Leuven, Belgium.; Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Verstockt S; Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Voskuil MD; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Winter HS; Massachusetts General Hospital, Boston, MA, USA., Young J; Crohn's and Colitis Foundation, New York, NY, USA., Duerr RH; University of Pittsburgh, Pittsburgh, PA, USA., Franke A; Christian-Albrechts-University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany., Brant SR; Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Crohn's Colitis Center of New Jersey, Department of Medicine, Rutgers Robert Wood Johnson Medical School and Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers University, New Brunswick and Piscataway, NJ, USA., Cho J; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Weersma RK; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Parkes M; Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Xavier RJ; Infectious Disease and Microbiome Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.; Kurt Isselbacher Professor of Medicine at Harvard Medical School, Cambridge, MA, USA.; Core Institute Member, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Immunology Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Microbiome Informatics and Therapeutics at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA., Rivas MA; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Rioux JD; Research Center Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Canada., McGovern DPB; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA., Huang H; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. hhuang@broadinstitute.org.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. hhuang@broadinstitute.org., Anderson CA; Genomics of Inflammation and Immunity Group, Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. carl.anderson@sanger.ac.uk., Daly MJ; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. mjdaly@broadinstitute.org.; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. mjdaly@broadinstitute.org.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. mjdaly@broadinstitute.org.; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland. mjdaly@broadinstitute.org.

Publikováno v: Nature genetics [Nat Genet] 2022 Sep; Vol. 54 (9), pp. 1275-1283. Date of Electronic Publication: 2022 Aug 29.

HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.

Autor: Sazonovs A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Kennedy NA; Department of Gastroenterology, Royal Devon and Exeter Hospital National Health Service Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Moutsianas L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Heap GA; Department of Gastroenterology, Royal Devon and Exeter Hospital National Health Service Foundation Trust, Exeter, UK; AbbVie Inc, North Chicago, Illinois., Rice DL; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Reppell M; AbbVie Inc, North Chicago, Illinois., Bewshea CM; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Chanchlani N; Department of Gastroenterology, Royal Devon and Exeter Hospital National Health Service Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Walker GJ; Department of Gastroenterology, Royal Devon and Exeter Hospital National Health Service Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Perry MH; Department of Blood Science, Royal Devon and Exeter Hospital National Health Service Foundation Trust, Exeter, UK., McDonald TJ; Department of Blood Science, Royal Devon and Exeter Hospital National Health Service Foundation Trust, Exeter, UK., Lees CW; Department of Gastroenterology, Western General Hospital, National Health Service Lothian, Edinburgh, UK., Cummings JRF; Department of Gastroenterology, University Hospital Southampton National Health Service Foundation Trust, Southampton, UK; Faculty of Experimental Medicine, University of Southampton, Southampton, UK., Parkes M; Department of Gastroenterology, Addenbrooke's Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK., Mansfield JC; Department of Gastroenterology, Newcastle Upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK., Irving PM; Department of Gastroenterology, Guy's and St Thomas' NHS Foundation, Trust, London, UK., Barrett JC; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., McGovern D; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California., Goodhand JR; Department of Gastroenterology, Royal Devon and Exeter Hospital National Health Service Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Anderson CA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. Electronic address: carl.anderson@sanger.ac.uk., Ahmad T; Department of Gastroenterology, Royal Devon and Exeter Hospital National Health Service Foundation Trust, Exeter, UK; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK. Electronic address: tariq.ahmad1@nhs.net.

Publikováno v: Gastroenterology [Gastroenterology] 2020 Jan; Vol. 158 (1), pp. 189-199. Date of Electronic Publication: 2019 Oct 07.

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.

Autor: Walker GJ; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England.; IBD Pharmacogenetics Group, University of Exeter, Exeter, England., Harrison JW; University of Exeter Medical School, Exeter, England., Heap GA; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England.; IBD Pharmacogenetics Group, University of Exeter, Exeter, England., Voskuil MD; Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, the Netherlands., Andersen V; Medical Department, Regional Hospital Viborg, Viborg, Denmark., Anderson CA; Wellcome Trust Sanger Institute, Hinxton, England., Ananthakrishnan AN; Department of Gastroenterology, Massachusetts General Hospital, Boston., Barrett JC; Wellcome Trust Sanger Institute, Hinxton, England., Beaugerie L; Department of Gastroenterology, Saint-Antoine Hospital and Sorbonne Universite, Paris, France., Bewshea CM; IBD Pharmacogenetics Group, University of Exeter, Exeter, England., Cole AT; Derby Digestive Diseases Centre, Royal Derby Hospital, Derby Teaching Hospitals NHS Foundation Trust, Derby, England., Cummings FR; Department of Gastroenterology, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, England., Daly MJ; Broad Institute, Harvard University, Cambridge, Massachusetts., Ellul P; Department of Gastroenterology, Mater Dei Hospital, Msida, Malta., Fedorak RN; Division of Gastroenterology, University of Alberta, Edmonton, Canada., Festen EAM; Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, the Netherlands., Florin TH; Mater Research Institute, University of Queensland, South Brisbane, Australia., Gaya DR; Department of Gastroenterology, Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde, Glasgow, Scotland., Halfvarson J; Division of Gastroenterology, Örebro University, Örebro, Sweden., Hart AL; Department of Gastroenterology, St Mark's Hospital, London North West Healthcare NHS Trust, Harrow, England., Heerasing NM; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England.; IBD Pharmacogenetics Group, University of Exeter, Exeter, England., Hendy P; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England.; IBD Pharmacogenetics Group, University of Exeter, Exeter, England., Irving PM; Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, England., Jones SE; University of Exeter Medical School, Exeter, England., Koskela J; Broad Institute, Harvard University, Cambridge, Massachusetts., Lindsay JO; Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, England., Mansfield JC; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, England., McGovern D; F. Widjaja Foundation Inflammatory Bowel Disease and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California., Parkes M; Department of Gastroenterology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England., Pollok RCG; Department of Gastroenterology, St George's Healthcare NHS Trust, Tooting, England., Ramakrishnan S; Gastrointestinal and Liver Services, Warrington and Halton Hospitals NHS Foundation Trust, Warrington, England., Rampton DS; Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, London, England., Rivas MA; Broad Institute, Harvard University, Cambridge, Massachusetts., Russell RK; Department of Paediatric Gastroenterology, Royal Hospital for Children, NHS Greater Glasgow and Clyde, Glasgow, Scotland., Schultz M; Dunedin Hospital, Dunedin, New Zealand., Sebastian S; Gastroenterology and Hepatology, Hull and East Yorkshire Hospitals NHS Trust, Hull, England., Seksik P; Department of Gastroenterology, Saint-Antoine Hospital and Sorbonne Universite, Paris, France., Singh A; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England., So K; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England., Sokol H; Department of Gastroenterology, Saint-Antoine Hospital and Sorbonne Universite, Paris, France., Subramaniam K; Canberra Hospital, Canberra, Australia., Todd A; Department of Haematology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England., Annese V; Division of Gastroenterology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy., Weersma RK; Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, the Netherlands., Xavier R; Broad Institute, Harvard University, Cambridge, Massachusetts., Ward R; University of Exeter Medical School, Exeter, England., Weedon MN; University of Exeter Medical School, Exeter, England., Goodhand JR; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England.; IBD Pharmacogenetics Group, University of Exeter, Exeter, England., Kennedy NA; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England.; IBD Pharmacogenetics Group, University of Exeter, Exeter, England., Ahmad T; Department of Gastroenterology, Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, England.; IBD Pharmacogenetics Group, University of Exeter, Exeter, England.

Publikováno v: JAMA [JAMA] 2019 Feb 26; Vol. 321 (8), pp. 773-785.

Corrigendum: Clinical Features and HLA Association of 5-Aminosalicylate (5-ASA)-induced Nephrotoxicity in Inflammatory Bowel Disease.

Autor: Heap GA; IBD Pharmacogenetics, Royal Devon and Exeter Foundation Trust, UK.; Precision Medicine Exeter, University of Exeter, UK., So K; IBD Pharmacogenetics, Royal Devon and Exeter Foundation Trust, UK.; Precision Medicine Exeter, University of Exeter, UK., Weedon M; Precision Medicine Exeter, University of Exeter, UK., Edney N; Exeter Kidney Unit, Royal Devon and Exeter Foundation Trust, UK., Bewshea C; IBD Pharmacogenetics, Royal Devon and Exeter Foundation Trust, UK.; Precision Medicine Exeter, University of Exeter, UK., Singh A; IBD Pharmacogenetics, Royal Devon and Exeter Foundation Trust, UK.; Precision Medicine Exeter, University of Exeter, UK., Vito A; University Hospital AOU, Department of Emergency, 2nd Gastroenterology Unit, Italy., Beckly J; Royal Cornwall Hospital NHS Trust, Penventinnie Lane, UK., Buurman D; Department of Gastroenterology and Hepatology, University of Groningen, The Netherlands.; University Medical Center Groningen, The Netherlands., Chaudhary R; Department of Gastroenterology, West Hertfordshire Hospitals NHS Trust, Watford General Hospital, UK.

Publikováno v: Journal of Crohn's & colitis [J Crohns Colitis] 2017 Dec 04; Vol. 11 (12), pp. 1509.