Bioactive molecules for regenerative pulp capping

Autor: LLE Whitehouse, NH Thomson, T Do, GA Feichtinger

Publikováno v: European Cells & Materials, Vol 42, Pp 415-437 (2021)

Since the discovery of bioactive molecules sequestered in dentine, researchers have been exploring ways to harness their activities for dental regeneration. One specific area, discussed in this review, is that of dental-pulp capping. Dental-pulp caps

Externí odkaz: https://doaj.org/article/f00045a70fb34a39a3e7e3ab33907fef

Constitutive and inducible co-expression systems for non-viral osteoinductive gene therapy

Autor: GA Feichtinger, A Hacobian, AT Hofmann, K Wassermann, A Zimmermann, M van Griensven, H Redl

Publikováno v: European Cells & Materials, Vol 27, Pp 166-184 (2014)

issue regenerative gene therapy requires expression strategies that deliver therapeutic effective amounts of transgenes. As physiological expression patterns are more complex than high-level expression of a singular therapeutic gene, we aimed at cons

Externí odkaz: https://doaj.org/article/a9fcad70aaaf43998b422d87bd89e289

Systematic Review of the Preclinical Technology Readiness of Orthopedic Gene Therapy and Outlook for Clinical Translation.

Autor: Wilkinson P; Division of Oral Biology, School of Dentistry, University of Leeds, Leeds, United Kingdom.; CDT Tissue Engineering and Regenerative Medicine, Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom., Bozo IY; Federal Medical Biophysical Center, Federal Medical-Biological Agency of Russia, Moscow, Russia., Braxton T; Division of Oral Biology, School of Dentistry, University of Leeds, Leeds, United Kingdom.; CDT Tissue Engineering and Regenerative Medicine, Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom., Just P; Into Numbers Data Science GmbH, Vienna, Austria., Jones E; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom., Deev RV; Ryazan State Medical University, Ryazan, Russia., Giannoudis PV; Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds General Infirmary, Leeds, United Kingdom.; NIHR Leeds Biomedical Research Centre, Chapel Allerton Hospital, Leeds, United Kingdom., Feichtinger GA; Division of Oral Biology, School of Dentistry, University of Leeds, Leeds, United Kingdom.

Publikováno v: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2021 Mar 17; Vol. 9, pp. 626315. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021).

Delivery of the improved BMP-2-Advanced plasmid DNA within a gene-activated scaffold accelerates mesenchymal stem cell osteogenesis and critical size defect repair.

Autor: Raftery RM; Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI and TCD, Dublin, Ireland., Mencía-Castaño I; Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI and TCD, Dublin, Ireland., Sperger S; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology/AUVA Research Center, The Austrian Cluster for Tissue Regeneration, European Institute of Excellence on Tissue Engineering and Regenerative Medicine Research (Expertissues EEIG), Vienna, Austria., Chen G; Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Microsurgical Research and Training Facility (MRTF), Royal College of Surgeons in Ireland, Dublin, Ireland., Cavanagh B; Cellular and Molecular Imaging Core, Royal College of Surgeons in Ireland, Dublin, Ireland., Feichtinger GA; Division of Oral Biology, School of Dentistry, Faculty of Medicine and Health, University of Leeds, United Kingdom., Redl H; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology/AUVA Research Center, The Austrian Cluster for Tissue Regeneration, European Institute of Excellence on Tissue Engineering and Regenerative Medicine Research (Expertissues EEIG), Vienna, Austria., Hacobian A; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology/AUVA Research Center, The Austrian Cluster for Tissue Regeneration, European Institute of Excellence on Tissue Engineering and Regenerative Medicine Research (Expertissues EEIG), Vienna, Austria., O'Brien FJ; Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI and TCD, Dublin, Ireland. Electronic address: fjobrien@rcsi.ie.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2018 Aug 10; Vol. 283, pp. 20-31. Date of Electronic Publication: 2018 May 19.

Improved osteogenic vector for non-viral gene therapy.

Autor: Hacobian AR; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A-1200 Vienna, Austria.ara.hacobian@trauma.lbg.ac.at., Posa-Markaryan K, Sperger S, Stainer M, Hercher D, Feichtinger GA, Schuh CM, Redl H

Publikováno v: European cells & materials [Eur Cell Mater] 2016 Mar 20; Vol. 31, pp. 191-204. Date of Electronic Publication: 2016 Mar 20.