Zobrazeno 1 - 10
of 1 452
pro vyhledávání: '"G9A"'
Publikováno v:
Animal Diseases, Vol 4, Iss 1, Pp 1-13 (2024)
Abstract Muscular atrophy accompanied by neuromuscular junction (NMJ) denervation is often observed after long-term chronic diseases and aging and is associated with substantial morbidity and mortality. Here, we report that histone methyltransferase
Externí odkaz:
https://doaj.org/article/57082c47964f4b018e0eee5a8b3dbd14
Autor:
Aiman Al-Ruwishan, Bushra Amer, Ahmed Salem, Ahmed Abdi, Namoonga Chimpandu, Abdelmonem Esa, Alexandros Melemenis, Muhammad Zubair Saleem, Roselit Mathew, Yaser Gamallat
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 8, Pp 8340-8367 (2024)
Despite recent advancements in technology, breast cancer still poses a significant threat, often resulting in fatal consequences. While early detection and treatments have shown some promise, many breast cancer patients continue to struggle with the
Externí odkaz:
https://doaj.org/article/b2c40c9c36904375920d6e62cd7b6769
Autor:
Amandda Évelin Silva-Carvalho, Luma Dayane Carvalho Filiú-Braga, Gabriela Muller Reche Bogéa, Alan Jhones Barbosa de Assis, Fábio Pittella-Silva, Felipe Saldanha-Araujo
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Histone methyltransferases (HMTs) are enzymes that regulate histone methylation and play an important role in controlling transcription by altering the chromatin structure. Aberrant activation of HMTs has been widely reported in certain type
Externí odkaz:
https://doaj.org/article/c2cb0ec651f545f39c00b7acc7b4f161
Autor:
Panagiotis Tsimpos, Simon Desiderio, Pauline Cabochette, Philippe Poelvoorde, Sadia Kricha, Luc Vanhamme, Coralie Poulard, Eric J. Bellefroid
Publikováno v:
Neural Development, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Prdm12 is an epigenetic regulator expressed in developing and mature nociceptive neurons, playing a key role in their specification during neurogenesis and modulating pain sensation at adulthood. In vitro studies suggested that Prdm12 recrui
Externí odkaz:
https://doaj.org/article/13e269671916462ebe2e42898c969349
Autor:
Aina Bellver-Sanchis, Pedro A Ávila-López, Iva Tic, David Valle-García, Marta Ribalta-Vilella, Luis Labrador, Deb Ranjan Banerjee, Ana Guerrero, Gemma Casadesus, Coralie Poulard, Mercè Pallàs, Christian Griñán-Ferré
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 11, Pp 2532-2542 (2024)
Dysregulation of G9a, a histone-lysine N-methyltransferase, has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative stress. Likewise, microRNAs are involved in many biological pro
Externí odkaz:
https://doaj.org/article/4c3e64e7fae94dd28b961cd5185e547a
Autor:
Gareth Pollin, Angela J. Mathison, Thiago M. de Assuncao, Anju Thomas, Atefeh Zeighami, Ann Salmonson, Hongfei Liu, Guillermo Urrutia, Pallavi Vankayala, Stephen J. Pandol, Johnny C. Hong, Michael T. Zimmermann, Juan Iovanna, Victor X. Jin, Raul Urrutia, Gwen Lomberk
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Introduction: The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the maturation and homeostasis of multiple organs. Recently, we have shown
Externí odkaz:
https://doaj.org/article/3ab3e4841b6348709cd8a96b6f115521
Autor:
Dexter Kai Hao Thng, Lissa Hooi, Clarissa Chin Min Toh, Jhin Jieh Lim, Deepa Rajagopalan, Imran Qamar Charles Syariff, Zher Min Tan, Masturah Bte Mohd Abdul Rashid, Lei Zhou, Alfred Wei Chieh Kow, Glenn Kunnath Bonney, Brian Kim Poh Goh, Juinn Huar Kam, Sudhakar Jha, Yock Young Dan, Pierce Kah Hoe Chow, Tan Boon Toh, Edward Kai‐Hua Chow
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2275-2294 (2023)
Hepatocellular carcinoma (HCC) is the third deadliest and sixth most common cancer in the world. Histone‐lysine N‐methyltransferase EHMT2 (also known as G9a) is a histone methyltransferase frequently overexpressed in many cancer types, including
Externí odkaz:
https://doaj.org/article/626aaf793fd742a0bc57798a71194ba1
Autor:
Luma Dayane de Carvalho Filiú-Braga, Amanda Évelin Silva-Carvalho, Marielly Reis Resende Sousa, Juliana Lott Carvalho, Felipe Saldanha-Araujo
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e27085- (2024)
In recent years, histone methyltransferases (HMTs) have emerged as important therapeutic targets in cancer due to their oncogenic role. Herein, we used the GLP/G9a inhibitor UNC0646 to assess whether the inhibition of such HMTs could induce cell deat
Externí odkaz:
https://doaj.org/article/d2318d0547354d83a6f8c672525136aa
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