Zobrazeno 1 - 10
of 87
pro vyhledávání: '"G6PC2"'
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 12, Iss 1, Pp 1-6 (2020)
Abstract Type 2 diabetes mellitus (T2DM) is a complex polygenic metabolic disease characterized by elevated blood glucose. Multiple environmental and genetic factors can increase the risk of T2DM and its complications, and genetic polymorphisms are n
Externí odkaz:
https://doaj.org/article/9b60b59cf562429b8ecdc545f23ef034
Autor:
Karin J. Bosma, Mohsin Rahim, James K. Oeser, Owen P. McGuinness, Jamey D. Young, Richard M. O'Brien
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101043- (2020)
Objective: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycl
Externí odkaz:
https://doaj.org/article/4701c9a4aec148bc85868d0b7a48679f
Autor:
Engin Atli, Selma Demir, Emine Ikbal Atli, Sinem Yalcintepe, Damla Eker, Fatma Özgüç Çömlek, Filiz Tütüncüler Kökenli, Hakan Gurkan
Publikováno v:
Journal of Clinical Research in Pediatric Endocrinology
JCRPE, Vol 13, Iss 3, Pp 320-331 (2021)
JCRPE, Vol 13, Iss 3, Pp 320-331 (2021)
Objective The aim of this study was to investigate the molecular basis of maturity-onset diabetes of the young by targeted-gene sequencing of 20 genes related to monogenic diabetes and estimate the frequency and describe the clinical characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c870c53724b86eee6e6e38e812b5d6c
http://europepmc.org/articles/PMC8388052
http://europepmc.org/articles/PMC8388052
Autor:
Martha Eunice Rodríguez-Arellano, Paula Costa-Urrutia, Jacqueline Solares-Tlapechco, Julio Granados, Rodrigo Fernández-Pons
Publikováno v:
The Open Diabetes Journal. 10:26-29
Background: In Mexico, type 2 diabetes prevalence is 13.7%, which has a huge impact on Mexican public health. There is an urgent need to focus on the prevention of pre-diabetes to decrease the likelihood of type 2 diabetes onset. Gene variants predis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e1f6a9b797cc147bb686d82870efde0
https://doi.org/10.2174/1876524602010010026
https://doi.org/10.2174/1876524602010010026
Akademický článek
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Akademický článek
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Autor:
Minjie Wang, Yizhong Peng, Bo Wang, Hongyang Zhao, Fenghu Ji, Chaocai Zhang, Jiandong Wu, Jiannong Zhao
Publikováno v:
BioMed Research International, Vol 2021 (2021)
BioMed Research International
BioMed Research International
Introduction. Glioblastoma (GBM) is one of the most frequent primary intracranial malignancies, with limited treatment options and poor overall survival rates. Alternated glucose metabolism is a key metabolic feature of tumour cells, including GBM ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c2c5b66c59bd7600a2fbd2cd133ea6
https://doaj.org/article/2b662a79f6f840138e3150b13a88f138
https://doaj.org/article/2b662a79f6f840138e3150b13a88f138
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2021 (2021)
BioMed Research International, Vol 2021 (2021)
Objective. To screen glycolytic genes linked to the glioma prognosis and construct the prognostic model. Methods. The relevant data of glioma were downloaded from TCGA and GTEx databases. GSEA of glycolysis-related pathways was carried out, and enric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b411a7afb36372acda5fe96db1fbbf
Autor:
Owen P. McGuinness, James K. Oeser, Jamey D. Young, Karin J. Bosma, Richard M. O'Brien, Mohsin Rahim
Publikováno v:
Molecular Metabolism, Vol 41, Iss, Pp 101043-(2020)
Molecular Metabolism
Molecular Metabolism
Objective G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee63edf033dbcb3dfd97e0b69febed0f
http://www.sciencedirect.com/science/article/pii/S2212877820301174
http://www.sciencedirect.com/science/article/pii/S2212877820301174
Autor:
Elisabetta Trabetti, M L Boselli, Elisabetta Rinaldi, Sara Bonetti, Giovanni Malerba, Enzo Bonora, Maddalena Trombetta, Chiara Zusi, Riccardo C. Bonadonna
Publikováno v:
Journal of endocrinological investigation. 44(12)
Elevated fasting plasma glucose has been associated with increased risk for development of type 2 diabetes (T2D). The balance between glucokinase (GCK) and glucose-6-phosphate catalytic subunit 2 (G6PC2) activity are involved in glucose homeostasis t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9847b044e907fad847e569caebc5970
https://pubmed.ncbi.nlm.nih.gov/34128214
https://pubmed.ncbi.nlm.nih.gov/34128214