Zobrazeno 1 - 10
of 149
pro vyhledávání: '"G.W. Johnston"'
Autor:
Emer E. Hackett, Hugo Charles-Messance, Seónadh M. O’Leary, Laura E. Gleeson, Natalia Muñoz-Wolf, Sarah Case, Anna Wedderburn, Daniel G.W. Johnston, Michelle A. Williams, Alicia Smyth, Mireille Ouimet, Kathryn J. Moore, Ed C. Lavelle, Sinéad C. Corr, Stephen V. Gordon, Joseph Keane, Frederick J. Sheedy
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 124-136.e4 (2020)
Summary: Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we observe repression of
Externí odkaz:
https://doaj.org/article/940d7725a10c42f3aa2a7e0bce32ab6d
Autor:
Hugo Charles-Messance, Anna Wedderburn, Emer E. Hackett, Ed C. Lavelle, Mireille Ouimet, Joseph Keane, Natalia Muñoz-Wolf, Laura E. Gleeson, Frederick J. Sheedy, Seónadh O'Leary, Kathryn J. Moore, Daniel G.W. Johnston, Michelle A. Williams, Sinéad C. Corr, Sarah Case, Stephen V. Gordon, Alicia Smyth
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 124-136.e4 (2020)
Cell Rep
Cell Rep
Summary: Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we observe repression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8629cd934a423927a68b9b180167aca1
http://www.sciencedirect.com/science/article/pii/S2211124719316651
http://www.sciencedirect.com/science/article/pii/S2211124719316651
Autor:
Eran Elinav, Paul D. Cotter, Sinéad C. Corr, Daniel G.W. Johnston, Michelle A. Williams, Raul Cabrera-Rubio, Craig P. McEntee, Mathilde Raverdeau, Luke A. J. O'Neill, Christoph A. Thaiss
Publikováno v:
Journal of Crohn's and Colitis. 12:835-848
Background and Aims microRNAs regulate gene expression and influence the pathogenesis of human diseases. The present study investigated the role of microRNA-21 [miR-21] in the pathogenesis of intestinal inflammation, because miR-21 is highly expresse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d2f89a17c73abdb79bca1e7fe2a707
https://doi.org/10.1093/ecco-jcc/jjy038
https://doi.org/10.1093/ecco-jcc/jjy038
Autor:
Sinéad C. Corr, Daniel G.W. Johnston
Publikováno v:
Methods in Molecular Biology ISBN: 9781493933334
Epithelial barrier function and innate immunity are fundamental to the pathogenesis of inflammatory and infectious disease. Along with plasma membranes, epithelial cells are the primary cellular determinant of epithelial barrier function. The mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8327a76013ff755bd4fa66912b4f7f0e
https://doi.org/10.1007/978-1-4939-3335-8_18
https://doi.org/10.1007/978-1-4939-3335-8_18
Autor:
Luke A. J. O'Neill, Clary B. Clish, Mario A.R. Lauterbach, Susan R. Quinn, Frederick J. Sheedy, Anne M. Curtis, Daniel G.W. Johnston, Joseph Keane, Gautam Goel, Craig J. Thomas, Raquel Domingo-Fernandez, William J. Israelsen, Matthew G. Vander Heiden, Eva M. Palsson-McDermott, Mirjam W.M. van den Bosch, Laura E. Gleeson, Ramnik J. Xavier, Jian-kang Jiang
SummaryMacrophages activated by the TLR4 agonist LPS undergo dramatic changes in their metabolic activity. We here show that LPS induces expression of the key metabolic regulator Pyruvate Kinase M2 (PKM2). Activation of PKM2 using two well-characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a098b127ed46129ab7464d688c98fbc0
https://europepmc.org/articles/PMC5198835/
https://europepmc.org/articles/PMC5198835/
Autor:
Luke A. J. O'Neill, Gabriella Aviello, Padraic G. Fallon, Daniel G.W. Johnston, Sinéad C. Corr
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 306(9)
Toll-like receptors (TLRs) play a central role in the recognition and response to microbial pathogens and in the maintenance and function of the epithelial barrier integrity in the gut. The protein MyD88 adaptor-like (Mal/TIRAP) serves as a bridge be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6050dd7e7923177bd3e71a80dada6f70
https://pubmed.ncbi.nlm.nih.gov/24603458
https://pubmed.ncbi.nlm.nih.gov/24603458
Publikováno v:
Molecular and cellular neurosciences. 56
Accumulating evidence continues to underpin the role of the innate immune system in pathologies associated with neuroinflammation. Innate immunity is regulated by pattern recognition receptors that detect pathogens, and in the case of Gram-positive b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc1948a0940639051190ff492f061ba
https://pubmed.ncbi.nlm.nih.gov/23659921
https://pubmed.ncbi.nlm.nih.gov/23659921
Akademický článek
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Akademický článek
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Publikováno v:
Journal of Laparoendoscopic Surgery. 3:73-74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4bbee68fb561c82e5bb0a8c3e5f3664
https://doi.org/10.1089/lps.1993.3.73
https://doi.org/10.1089/lps.1993.3.73