Zobrazeno 1 - 10
of 354
pro vyhledávání: '"G.S. Tint"'
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 7, Pp 1535-1541 (2006)
Mice with a targeted mutation of 3β-hydroxysterol Δ7-reductase (Dhcr7) that cannot convert 7-dehydrocholesterol to cholesterol were used to identify the origin of fetal sterols. Because their heterozygous mothers synthesize cholesterol normally, vi
Externí odkaz:
https://doaj.org/article/e41e1b5696a94859ba5b0622a12ea980
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 11, Pp 2044-2051 (2004)
Three major long-term effects of sterol deprivation in Caenorhabditis elegans are described. 1) The life expectancy of sterol-deprived wild-type animals is decreased by more than 40%. Similar decreases are found in animals carrying mutations in the d
Externí odkaz:
https://doaj.org/article/1508977d29214fd09254b595378403f6
Autor:
L.M. Refolo, M.A. Pappolla, J. LaFrancois, B. Malester, S.D. Schmidt, T. Thomas-Bryant, G.S. Tint, R. Wang, M. Mercken, S.S. Petanceska, K.E. Duff
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 5, Pp 890-899 (2001)
Clinical, epidemiological, and laboratory studies suggest that cholesterol may play a role in the pathogenesis of Alzheimer's disease (AD). Transgenic mice exhibiting an Alzheimer's β-amyloid phenotype were treated with the cholesterol-lowering drug
Externí odkaz:
https://doaj.org/article/12bdc1b469f74658871dafb93418b49e
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 2, Pp 195-200 (2001)
The effects of feeding cholesterol, sitosterol, and lovastatin on cholesterol absorption, biosynthesis, esterification, and LDL receptor function were examined in the rat jejunal mucosa. Cholesterol absorption was measured by the dual-isotope plasma
Externí odkaz:
https://doaj.org/article/fe2ec2f5c03d4b7fbbb09e3bb8d73a77
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 11, Pp 1883-1889 (2000)
We measured the percent absorption, turnover, and distribution of campestanol (24-methyl-5α-cholestan-3β-ol) in a sitosterolemic homozygote, her obligate heterozygous mother, and three healthy human control subjects. For reasons relating to sterol
Externí odkaz:
https://doaj.org/article/d4c9aa5aa9ce42988a4a65d16797bdd4
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 12, Pp 2471-2476 (1998)
The mechanism for the catalytic reduction of the double bond at C-7,8 in 7-dehydrocholesterol by 3β-hydroxysterol Δ7-reductase was investigated by testing structurally related sterols as substrates and potential inhibitors. The hepatic smooth endop
Externí odkaz:
https://doaj.org/article/378fbd644dd646b39cfc0c25cd2ef0ea
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 3, Pp 647-657 (1998)
The Smith-Lemli-Opitz syndrome (SLOS) is a common birth defect–mental retardation syndrome caused by a defect in the enzyme that reduces 7-dehydrocholesterol to cholesterol. Because of this block, patients' plasma cholesterol levels are generally l
Externí odkaz:
https://doaj.org/article/bb9e9960b4bc43599467ee1b265293c2
Publikováno v:
Journal of Lipid Research, Vol 16, Iss 4, Pp 280-286 (1975)
This paper describes studies dealing with the nature of the C27 pentahydroxy bile alcohols present in the bile and feces of two patients with cerebrotendinous xanthomatosis (CTX). The presence of a bile alcohol having the structure 5β-cholestane-3α
Externí odkaz:
https://doaj.org/article/07cb60b151054b9b9a5f4601678ead97
Autor:
G.S. Tint, Gerald Salen
Publikováno v:
Journal of Lipid Research, Vol 15, Iss 3, Pp 256-262 (1974)
The metabolism of Δ7-cholestenol, cholesterol, and cholestanol was examined in a patient with cerebrotendinous xanthomatosis after intravenous pulse-labeling with a mixture of dl-[2-14C]mevalonate and stereospecific 3S,4S,3R,4R-[4-3H]-mevalonate. Si
Externí odkaz:
https://doaj.org/article/7a1795041f6f49ccbd9529d4b9c67262
Publikováno v:
Developmental Neuroscience. 36:132-142
Cholesterol synthesis in the fetal brain is inhibited because activity of DHCR24 (24-dehydrocholesterol reductase) is insufficient, causing concentrations of the precursor desmosterol to increase temporarily to 15-25% of total sterols at birth. We de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b061011e9fc15337f4c7f686b141ca
https://doi.org/10.1159/000362363
https://doi.org/10.1159/000362363