Zobrazeno 1 - 10 of 22 pro vyhledávání: '"G.S. Provost"'
1
System issues: Mutagenic response to benzene andTris(2,3-dibromopropyl)-phosphate in the lambdalacl transgenic mouse mutation assay: A standardized approach to in vivo mutation analysis
Autor: Jon C. Mirsalis, G.S. Provost, B. J. Rogers, Jay M. Short
Publikováno v: Environmental and Molecular Mutagenesis. 28:342-347
The genotoxic response of benzene and tris(2,3-dibromopropyl)-phosphate (TDBP) have been evaluated in several tissues using the standardized lambda/lacI (Big Blue) transgenic mouse mutation assay. Separate groups of four to five male B6C3F1 transgeni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eda8877bd3b9c469d3b5d2971f2d2558
https://doi.org/10.1002/(sici)1098-2280(1996)28:4<342::aid-em7>3.0.co
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2
Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice
Autor: Patricia L. Kretz, Joseph A. Sorge, D L Putman, S W Kohler, W O Bullock, Annabeth Fieck, Jay M. Short, G.S. Provost
Publikováno v: Proceedings of the National Academy of Sciences. 88:7958-7962
Transgenic mice with a lambda shuttle vector containing a lacI target gene were generated for use as a short-term, in vivo mutagenesis assay. The gene is recovered from the treated mice by exposing mouse genomic DNA to in vitro packaging extracts and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e029efbbffd0a251ce91b7ac7e80095
https://doi.org/10.1073/pnas.88.18.7958
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3
Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vector
Autor: Annabeth Fieck, Patricia L. Kretz, G.S. Provost, Jay M. Short, D L Putman, S W Kohler, W O Bullock, Joseph A. Sorge
Publikováno v: Environmental and Molecular Mutagenesis. 18:316-321
A short term, in vivo mutagenesis assay has been developed utilizing a lacl target gene contained within a lambda ZAP shuttle vector which has been incorporated into transgenic mice. Following chemical exposure, the target gene was recovered from mou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ed508941a290163a2927431f55b79f
https://doi.org/10.1002/em.2850180421
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4
Species-specific differences in hepatic mutant frequency and mutational spectrum among lambda/lacI transgenic rats and mice following exposure to aflatoxin B1
Autor: Barry W. Glickman, G.S. Provost, J.G. de Boer, M. Dycaico, Gregory R. Stuart, G.M. Tobal
Publikováno v: Carcinogenesis. 17(11)
In vivo mutations were studied in lambda/lacI (Big Blue) transgenic C57BL/6 mice and F344 rats following exposure to either AFB1 (aflatoxin B1) or DMSO vehicle. Fourteen days after exposure, livers were removed for DNA extraction and subsequent mutat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e6fb457ebebfa57f75694aada41083
https://pubmed.ncbi.nlm.nih.gov/8968048
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5
Mutagenicity of o-anisidine to the bladder of lacI- transgenic B6C3F1 mice: absence of 14C or 32P bladder DNA adduction
Autor: P. A. Lefevre, Jay M. Short, Brenda J. Rogers, James M. Parry, Nigel J. Jones, Helen Tinwell, K. Burnette, B.W. GIickman, E.A. Martin, John Ashby, G.S. Provost
Publikováno v: Carcinogenesis. 15(10)
Earlier studies have established that the rodent bladder carcinogen o-anisidine (OA) gives negative results in all of the standard rodent genetic toxicity assays. In the present study, a single oral administration of the maximum tolerated dose level
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6ce316f753cb961461a92348ae0e20
https://pubmed.ncbi.nlm.nih.gov/7955069
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6
The use of shuttle vectors for mutation analysis in transgenic mice and rats
Autor: Ransom Sl, Moores Jc, G.S. Provost, P.L. Kretz, Jay M. Short, Mark J. Dycaico
Publikováno v: Mutation research. 307(2)
The establishment in recent years of transgenic shuttle vector-based mutagenicity assays has provided improved systems for analysis of mutagenic and carcinogenic processes. Results in the mouse have stimulated the development of an alternate species
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e5f27b36e660c68a19874feaae0062
https://pubmed.ncbi.nlm.nih.gov/7514720
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10
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