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Akademický článek
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Autor:
Gayle A. Orner, G.S. Bailey, Clifford B. Pereira, Jerry D. Hendricks, David E. Williams, Aram Oganesian
Publikováno v:
Carcinogenesis. 20:453-458
Indole-3-carbinol (I3C), a metabolite of glucobrassicin found in cruciferous vegetables, is documented as acting as a modulator of carcinogenesis and, depending on timing and dose of administration, it may promote hepatocarcinogenesis in some animal
Autor:
David E. Williams, Herman A.J. Schut, M. Xu, G.S. Bailey, Leonard F. Bjeldanes, Roderick H. Dashwood
Publikováno v:
Carcinogenesis. 18:2149-2153
Indole-3-carbinol (I3C) inhibits the formation of colonic aberrant crypt foci and DNA adducts in rats given heterocyclic amine colon carcinogens, such as 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Mechanism studies indicate that I3C induces cytoch
Publikováno v:
Food and Chemical Toxicology. 33:851-857
Possible inhibitory mechanisms of indole-3-carbinol (I3C) against aflatoxin B1 (AFB1), a potent hepatocarcinogen, were examined in rainbow trout. In the Salmonella assay using a trout post-mitochondrial activation system, I3C itself was not an antimu
Autor:
Christiane V. Loehr, Clifford B. Pereira, Mandy A. Louderback, David E. Williams, G.S. Bailey, Kay A. Fischer, Nancy I. Kerkvliet, Mark Steven Miller, Sharon K. Krueger, Zhen Yu, Jamie Jennings-Gee, Roderick H. Dashwood, Stephanie T. Dance
Publikováno v:
Cancer research. 66(2)
Lymphoma and leukemia are the most common cancers in children and young adults; in utero carcinogen exposure may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was given to pregnant mic
Autor:
T.S. Elthaher, G.S. Bailey
Publikováno v:
Analytical biochemistry. 217(2)
Publikováno v:
Carcinogenesis. 22:685-685
Publikováno v:
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 51:429-438
1. 1. Methods for the partial purification of nerve growth factor from five different snake venoms are described. 2. 2. The physico-chemical properties of the different proteins are compared and the difficulties involved in the isolation of the facto
Autor:
Daniel N. Arbogast, Rod H. Dashwood, G.S. Bailey, A.T. Fong, Clifford B. Pereira, Jerry D. Hendricks
Publikováno v:
Carcinogenesis. 10(1)
A number of recent studies have described inhibitor-mediated reductions in the covalent DNA binding and tumorigenicity of various carcinogens, in species such as rats, mice and rainbow trout (Salmo gairdneri). Since inhibitory effects have, in most c