Zobrazeno 1 - 3
of 3
pro vyhledávání: '"G.R.M. Manchee"'
Autor:
G.M. Drew, A. Travers, B.C. Ross, T.A. Panchal, E. Palmer, Steve P. Watson, A. Hilditch, David Middlemiss, J.G. Montana, M.J. Robertson, A.A.E. Hunt, G.R.M. Manchee, G.C. Hirst, J.M.S. Paton, T. Hubbard, David I. C. Scopes, G. Stuart, M.D. Dowle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2043-2046
A series of GR117289 derived amino acid-amide angiotensin II antagonists is described. The possibility that the amino acid-amide element of these molecules mimics the C-terminus of Angiotensin II is discounted. One of these compounds, (2g), exhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a49036050cc030106b1f6c893bf2e68e
https://doi.org/10.1016/s0960-894x(01)81011-8
https://doi.org/10.1016/s0960-894x(01)81011-8
Autor:
Kenneth Lyle Clark, Steven J Coote, K.S. Cardwell, J.G. Montana, Steve P. Watson, G.C. Hirst, G.R.M. Manchee, J. Hamblett, M.J. Robertson, David Middlemiss, M. Donnelly, B.C. Ross, T.A. Panchal, E. Palmer, J.M.S. Paton, A. Hilditch, G.M. Drew, David I. C. Scopes, M. Pass, M.D. Dowle, J. Bradshaw, Torquil I. Jack, T. Hubbard, M.K. Bayliss, G. Stuart, P. Shah
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:589-594
A study of structure activity relationships based on the bromobenzofuran angiotensin II antagonist GR117289 is reported. This study led to the identification of compounds with potency in vitro enhanced by ca. 10 fold. Also reported is the enhancement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbaea88e6d2f5f5513c4ccd3cdac2b65
https://doi.org/10.1016/s0960-894x(01)81235-x
https://doi.org/10.1016/s0960-894x(01)81235-x
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