Zobrazeno 1 - 10
of 607
pro vyhledávání: '"G.R. Scott"'
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Advancing age is the most important risk factor for the development of and mortality from acute and chronic lung diseases, including pneumonia, chronic obstructive pulmonary disease, and pulmonary fibrosis. This risk was manifest during the COVID-19
Externí odkaz:
https://doaj.org/article/1f852d297b8b4e7f9fb43e1e34959869
Autor:
Catherine A. Gao, Nikolay S. Markov, Thomas Stoeger, Anna Pawlowski, Mengjia Kang, Prasanth Nannapaneni, Rogan A. Grant, Chiagozie Pickens, James M. Walter, Jacqueline M. Kruser, Luke Rasmussen, Daniel Schneider, Justin Starren, Helen K. Donnelly, Alvaro Donayre, Yuan Luo, G.R. Scott Budinger, Richard G. Wunderink, Alexander V. Misharin, Benjamin D. Singer, The NU SCRIPT Study Investigators
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
BACKGROUND Despite guidelines promoting the prevention and aggressive treatment of ventilator-associated pneumonia (VAP), the importance of VAP as a driver of outcomes in mechanically ventilated patients, including patients with severe COVID-19, rema
Externí odkaz:
https://doaj.org/article/f2a85cfc68d846f1a4d5f04bb23bd1d4
Autor:
Anna B. Montgomery, Shang Yang Chen, Yidan Wang, Gaurav Gadhvi, Maximilian G. Mayr, Carla M. Cuda, Salina Dominguez, Hadijat-Kubura Moradeke Makinde, Miranda G. Gurra, Alexander V. Misharin, Arthur M. Mandelin, Eric M. Ruderman, Anjali Thakrar, Simran Brar, Mary Carns, Kathleen Aren, Mahzad Akbarpour, Andrew Filer, Saba Nayar, Ana Teososio, Triin Major, Ankit Bharat, G.R. Scott Budinger, Deborah R. Winter, Harris Perlman
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112513- (2023)
Summary: Monocytes are abundant immune cells that infiltrate inflamed organs. However, the majority of monocyte studies focus on circulating cells, rather than those in tissue. Here, we identify and characterize an intravascular synovial monocyte pop
Externí odkaz:
https://doaj.org/article/adaf60afb9b54ac7aee8d7562ca316cc
Autor:
Laura A. Dada, Lynn C. Welch, Natalia D. Magnani, Ziyou Ren, Hyebin Han, Patricia L. Brazee, Diego Celli, Annette S. Flozak, Anthea Weng, Mariana Maciel Herrerias, Vitalii Kryvenko, István Vadász, Constance E. Runyan, Hiam Abdala-Valencia, Masahiko Shigemura, S. Marina Casalino-Matsuda, Alexander V. Misharin, G.R. Scott Budinger, Cara J. Gottardi, Jacob I. Sznajder
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are among the most common symptoms in patients with COVID-19 after hospital discharge. In mechanically ventilated patients with acute respiratory distress syndrome (A
Externí odkaz:
https://doaj.org/article/27f8a7d5d6534376bca1fe588efdba2a
Autor:
Wenbin Yang, Emily Jeong Cerier, Félix L. Núñez-Santana, Qiang Wu, Yuanqing Yan, Chitaru Kurihara, Xianpeng Liu, Anjana Yeldandi, Nigar Khurram, Diego Avella-Patino, Haiying Sun, G.R. Scott Budinger, Daniel Kreisel, Thalachallour Mohanakumar, Emilia Lecuona, Ankit Bharat
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)
Preexisting lung-restricted autoantibodies (LRAs) are associated with a higher incidence of primary graft dysfunction (PGD), although it remains unclear whether LRAs can drive its pathogenesis. In syngeneic murine left lung transplant recipients, pre
Externí odkaz:
https://doaj.org/article/6acb2674719446cabb799ad8228631c6
Autor:
Melissa Querrey, Stephen Chiu, Emilia Lecuona, Qiang Wu, Haiying Sun, Megan Anderson, Megan Kelly, Sowmya Ravi, Alexander V. Misharin, Daniel Kreisel, Ankit Bharat, G.R. Scott Budinger
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)
Primary graft dysfunction (PGD) is the leading cause of postoperative mortality in lung transplant recipients and the most important risk factor for development of chronic lung allograft dysfunction. The mechanistic basis for the variability in the i
Externí odkaz:
https://doaj.org/article/4eea2c26b2e1418d8349f39ba1a3756b
Autor:
Jing Yang, Hanh Chi Do-Umehara, Qiao Zhang, Huashan Wang, Changchun Hou, Huali Dong, Edith A. Perez, Marc A. Sala, Kishore R. Anekalla, James M. Walter, Shuwen Liu, Richard G. Wunderink, G.R. Scott Budinger, Jing Liu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Sepsis and acute lung injury (ALI) are linked to mitochondrial dysfunction; however, the underlying mechanism remains elusive. We previously reported that c-Jun N-terminal protein kinase 2 (JNK2) promotes stress-induced mitophagy by targeting small m
Externí odkaz:
https://doaj.org/article/c8ed6666624b4fa99b7c46a6cb604a90
Autor:
Chitaru Kurihara, Emilia Lecuona, Qiang Wu, Wenbin Yang, Félix L. Núñez-Santana, Mahzad Akbarpour, Xianpeng Liu, Ziyou Ren, Wenjun Li, Melissa Querrey, Sowmya Ravi, Megan L. Anderson, Emily Cerier, Haiying Sun, Megan E. Kelly, Hiam Abdala-Valencia, Ali Shilatifard, Thalachallour Mohanakumar, G.R. Scott Budinger, Daniel Kreisel, Ankit Bharat
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
Primary graft dysfunction (PGD) is the predominant cause of early graft loss following lung transplantation. We recently demonstrated that donor pulmonary intravascular nonclassical monocytes (NCM) initiate neutrophil recruitment. Simultaneously, hos
Externí odkaz:
https://doaj.org/article/cb3ce52f508540b4bd16d407b8b2ff90
Publikováno v:
European Respiratory Review, Vol 29, Iss 156 (2020)
The complex cellular heterogeneity of the lung poses a unique challenge to researchers in the field. While the use of bulk RNA sequencing has become a ubiquitous technology in systems biology, the technique necessarily averages out individual contrib
Externí odkaz:
https://doaj.org/article/7667f95128a549c4ae4457345608c404
Autor:
Paul Cheresh, Seok-Jo Kim, Long Shuang Huang, Satoshi Watanabe, Nikita Joshi, Kinola J.N. Williams, Monica Chi, Ziyan Lu, Anantha Harijith, Anjana Yeldandi, Anna P. Lam, Cara Gottardi, Alexander V. Misharin, G.R. Scott Budinger, Viswanathan Natarajan, David W. Kamp
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5595 (2020)
Idiopathic pulmonary fibrosis (IPF) is a chronic disease for which novel approaches are urgently required. We reported increased sphingosine kinase 1 (SPHK1) in IPF lungs and that SPHK1 inhibition using genetic and pharmacologic approaches reduces mu
Externí odkaz:
https://doaj.org/article/f324b6841ca8499c9572aaa4603847fa