Výsledky vyhledávání - "G.R. Bicknell"

Akademický článek

Reproducibility in the Quantification of mRNA Levels by RT-PCR-ELISA and RT Competitive-PCR-ELISA

Autor: L.L. Hall, G.R. Bicknell, L. Primrose, J.H. Pringle, J.A. Shaw, P.N. Furness

Publikováno v: BioTechniques, Vol 24, Iss 4, Pp 652-658 (1998)

The use of reverse transcription (RT) PCR for relative quantitation of gene transcripts relies on the reproducibility of the individual RT, PCR and product measurement steps. Semi-competitive RT-PCR (RT-cPCR) uses an internal competitor template in t

Externí odkaz: https://doaj.org/article/c849275dd14b4871bcdd03dbda041b20

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Differential expression of cytoprotective and apoptotic genes in an ischaemia-reperfusion isolated organ perfusion model of the transplanted kidney

Autor: G.R. Bicknell, Sarah A. Hosgood, Monika Kaushik, Michael L. Nicholson, Bin Yang, Atul Bagul, Helen L. Waller, Simon J. F. Harper, Mark D. Kay

Publikováno v: Transplant International. 20:625-631

The optimal kidney preservation system and methods to ameliorate reperfusion injury are major factors in accomplishing successful graft function following transplantation. Ischaemia and reperfusion lead to cellular stress and the adaptive response ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d261d9a5ab25620020441cf50bc6738
https://doi.org/10.1111/j.1432-2277.2007.00489.x

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The novel antifibrotic agent pirfenidone attenuates the profibrotic environment generated by calcineurin inhibitors in the rat salt-depletion model

Autor: G.R. Bicknell, J R Waller, M. L. Nicholson, Nicholas R. Brook

Publikováno v: Transplantation Proceedings. 37:130-133

Calcineurin inhibitors (CNIs) promote fibrosis in renal allografts by altering the dynamics of extracellular matrix (ECM) turnover. Graft structure is changed and functional disturbance may follow. This study examined the effects of an antifibrotic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a6903c1707ff47544844b7d7ed1883
https://doi.org/10.1016/j.transproceed.2004.12.150

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Rapamycin reduces expression of fibrosis-associated genes in an experimental model of renal ischaemia reperfusion injury

Autor: P. H. Whiting, S Jain, G.R Bicknell, M. L. Nicholson

Publikováno v: Transplantation Proceedings. 33:556-558

CHRONIC ALLOGRAFT nephropathy (CAN) remains a major cause of renal transplant failure. It is characterised by a progressive functional deterioration, which is associated histologically with graft fibrosis. Cyclosporin has no impact on the development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa5e402903d10dbd28dc4a8404d2117
https://doi.org/10.1016/s0041-1345(00)02141-2

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Cyclosporine and rapamycin act in a synergistic and dose-dependent manner in a model of immunosuppressant-induced kidney damage

Autor: G.R. Bicknell, Nicholas R. Brook, J R Waller, M. L. Nicholson

Publikováno v: Transplantation proceedings. 37(2)

The combination of cyclosporine (CSA) and rapamycin (RAPA) is a potent and commonly used approach to immunosuppression following solid-organ transplantation. By applying varying doses of CSA and RAPA to the rat salt-depleted model, we aimed to find a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990a23990de26074f5c2ab879a858937
https://pubmed.ncbi.nlm.nih.gov/15848549

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Effects of the combination of rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia

Autor: G.R. Bicknell, M. L. Nicholson, Gavin J. Murphy, J R Waller, D. Toomey

Publikováno v: The British journal of surgery. 89(11)

Background Allograft vasculopathy remains the leading cause of late allograft failure following transplantation and can be inhibited by the antiproliferative drug rapamycin. This study assessed the efficacy of combining rapamycin therapy with calcine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f448d7498e639f2b3af7069ee32701
https://pubmed.ncbi.nlm.nih.gov/12390379

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