Zobrazeno 1 - 10
of 37
pro vyhledávání: '"G.P.B. Kraan"'
Autor:
B.G. Wolthers, G.P.B. Kraan
Publikováno v:
Journal of Chromatography A. 843:247-274
This review article underlines the importance of gas chromatography-mass spectrometry (GC-MS) for determination of steroids in man. The use of steroids labelled with stable isotopes as internal standard and subsequent analysis by GC-MS yields up to n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc4fc2836beb58f87888a5e5c4d3a5b
https://doi.org/10.1016/s0021-9673(99)00153-3
https://doi.org/10.1016/s0021-9673(99)00153-3
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 83:1247-1252
We have measured the urinary cortisol production rate (uCPR) simultaneously with the serum cortisol production rate (sCPR) in four healthy men within a period of 3 days. uCPR, determined by isotope dilution of 11-oxoetiocholanolone was compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8ced86b02fd4eab86a1bbe195220704
https://doi.org/10.1210/jcem.83.4.4694
https://doi.org/10.1210/jcem.83.4.4694
Autor:
C.W. Rouwe, J.C. van der Molen, F. Lenting, E.R. Boersma, G.T. Nagel, G.P.B. Kraan, B.G. Wolthers
Publikováno v:
Clinica chimica acta, 236(1), 33-43. ELSEVIER SCIENCE BV
A case is described of a newborn, admitted to hospital because of severe salt loss at the age of 1 month. Subsequent analysis of urinary steroid excretion, by gas chromatography and gas chromatography-mass spectrometry, revealed that the patient suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9052a00cacd0cfefe70e6715701fc3fc
https://doi.org/10.1016/0009-8981(95)06034-7
https://doi.org/10.1016/0009-8981(95)06034-7
Autor:
J.C. van der Molen, R.W.J. Zijlstra, G.T. Nagel, J. Hartstra, N.M. Drayer, W.H. Kruizinga, G.P.B. Kraan, B.G. Wolthers
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 49:233-244
The synthesis and identification of 12 A-ring reduced 6 alpha-(and 6 beta-)hydroxylated compounds derived from 11-deoxycortisol (S), corticosterone (B) and 11-dehydrocorticosterone (A) are reported here. These steroids were prepared in two steps from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea629632c4640cc6e2341c839e6c5fe
https://doi.org/10.1016/0960-0760(94)90015-9
https://doi.org/10.1016/0960-0760(94)90015-9
Publikováno v:
Journal of steroid biochemistry and molecular biology, 42(2), 169-177. PERGAMON-ELSEVIER SCIENCE LTD
A new model is proposed to study the kinetics of [H-3]cortisol metabolism by using urinary data only. The model consists of 5 pools, in which changes of the fractions of dose are given by a system of 5 ordinary differential equations. After i.v. admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442ac4ca33a91f3462c68e356fe4a2bb
https://doi.org/10.1016/0960-0760(92)90025-e
https://doi.org/10.1016/0960-0760(92)90025-e
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 38:489-496
[1,2,3,4-C-13]cortisol was i.v. administered to two sisters aged 11 yr (patient I) and 3 yr (patient II) who suffer from 17-alpha-hydroxylase deficiency. This is the first time that the cortisol production rate (CPR) in patients with 17-alpha-hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b99641784e1b36500865e18c13dd35f
https://doi.org/10.1016/0960-0760(91)90337-5
https://doi.org/10.1016/0960-0760(91)90337-5
Autor:
Nick M. Drayer, G.P.B. Kraan
Publikováno v:
Steroids, 55(4), 159-164. ELSEVIER SCIENCE INC
A urinary method of determining the cortisol production rate (CPR) in children was studied under physiologic conditions by administration of low amounts of [1,2,3,4-13C]cortisol. The CPR in three patients with multiple pituitary deficiency ranged fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede916a3943f605f350b60c8862bd140
https://doi.org/10.1016/0039-128x(90)90104-j
https://doi.org/10.1016/0039-128x(90)90104-j
Publikováno v:
Journal of steroid biochemistry and molecular biology, 63(1-3), 139-146. PERGAMON-ELSEVIER SCIENCE LTD
The kinetics of cortisol in the serum of 4 healthy men were studied following single i.v. doses of 2 and 0.8 mg of cortisol. The disappearance of cortisol was determined by blood sampling frequently over 2.5 h and analysing the apparently biexponenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db00bd09b6a957fad954a6264eb91d7c
https://pubmed.ncbi.nlm.nih.gov/9449215
https://pubmed.ncbi.nlm.nih.gov/9449215
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 45(5)
The identification of 3 new 15 beta-hydroxylated 21-deoxy-pregnanes in the urinary steroid profile of a 4-month-old girl with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is reported here. These steroids were identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdbe49a9630910736685a96111fd39a
https://pubmed.ncbi.nlm.nih.gov/8499349
https://pubmed.ncbi.nlm.nih.gov/8499349
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 44(1)
The kinetic features of 11-deoxycortisol (S) were studied in a 11 beta-hydroxylase deficient boy. After i.v. administration of 35 kBq [3H]S (11 pmol) together with 44 nmol [13C]cortisol all his urine was collected during the next 3 days. A recently r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7b5ce60a78e0ee0055a207a5cd58bc
https://pubmed.ncbi.nlm.nih.gov/8424891
https://pubmed.ncbi.nlm.nih.gov/8424891