Zobrazeno 1 - 10
of 112
pro vyhledávání: '"G.P. van der Schans"'
Autor:
Andrew Collins, Jan H.J. Hoeijmakers, R. Montesano, Ethel Moustacchi, Miria Stefanini, Claude Backendorf, G.P. van der Schans, R.P.D. Fuchs, Małgorzata Z. Zdzienicka, Geoffrey P. Margison, Bryn A. Bridges, A.A. van Zeeland, L.H. Thompson, Christine A. Weber, Charles Allen Smith, Erling Seeberg, Alain Sarasin, Adayapalam T. Natarajan, Alan R. Lehmann, Miroslav Radman
Publikováno v:
Mutation Research/DNA Repair. 273:1-28
A workshop on DNA repair with emphasis on eukaryotic systems was held, under the auspices of the EC Concerted Action on DNA Repair and Cancer, at Noordwijkerhout (The Netherlands) 14-19 April 1991. The local organization of the meeting was done under
Publikováno v:
Carcinogenesis, 3, 13, 457-462
Exposure of cells to ionizing radiation gives rise to DNA damage, comprising strand breaks and base modifications. All these lesions may contribute to cell death, mutagenesis and/or carcinogenesis, but their relative contributions are likely to be di
Publikováno v:
Mutation Research/DNA Repair. 235:129-135
The role of UV-induced DNA lesions and their repair in the formation of chromosomal aberrations in the xrs mutant cell lines xrs 5 and xrs 6 and their wild-type counterpart, CHO-K1 cells, were studied. The extent of induction of DNA single-strand bre
Autor:
L.P.A. de Jong, Daan Noort, Roos H. Mars-Groenendijk, G.P. van der Schans, Hendrik P. Benschop
Publikováno v:
Journal of analytical toxicology. 28(5)
A standard operating procedure has been developed for an immunoslotblot assay of sulfur mustard adducts to DNA in human blood and skin for use in a field laboratory. A minimum detectable level of exposure of human blood in vitro (> or = 50 nM) sulfur
Autor:
Adayapalam T. Natarajan, Roberta Meschini, Lubomir Stoilov, G.P. van der Schans, Firouz Darroudi, Leon H.F. Mullenders
Publikováno v:
Scopus-Elsevier
Sodium butyrate is known to inhibit histone deacetylase enzymes and to enhance the frequencies of X-ray-induced dicentrics and rings in human lymphocytes. In this study an investigation was made of the mechanisms underlying this enhancement by assess
Autor:
Jan P. Langenberg, G.P. van der Schans, Roos H. Mars-Groenendijk, H. C. M. Van Dijk-Knijnenburg, Hendrik P. Benschop, Willem C. Kuijpers, Henk C. Trap, H.P.M. van Helden, Helma E.T. Spruit
Publikováno v:
Drug and chemical toxicology. 21
In order to provide a quantitative basis for pretreatment and therapy of intoxications with sulfur mustard (SM) the toxicokinetics of this agent as well as its major DNA-adduct were studied in male hairless guinea pigs for the intravenous, respirator
Publikováno v:
Photochemistry and photobiology. 66(6)
An immunochemical assay, i.e. sandwich enzyme-linked immunosorbent assay, has been modified to detect UV-induced damage in cellular DNA of monolayer-grown human melanocytes. The method is based on the binding of a monoclonal antibody to single-strand
Publikováno v:
Mutation research. 314(2)
Previously, it has been shown that the V-H4 mutant of Chinese hamster V79 cells is homologous to Fanconi anemia (FA) group A cells. This hamster cell mutant shows a specific sensitivity to DNA cross-linking agents; therefore, the induction and repair
Publikováno v:
Mutation Research, 294, 235-245
The induction of DNA interstrand cross-links and their repair has been studied in cultured human epidermal keratinocytes exposed to sulfur mustard, bis-(beta-chloroethyl)sulfide. Alkaline elution is the most sensitive method to determine the number o
Autor:
J. Hoogerbrugge, E. Sonneveld, Paul H.M. Lohman, Robert A. Baan, G.P. van der Schans, J.A. Grootegoed, A.A.W.M. van Loon
Publikováno v:
Mutation Research-DNA Repair Reports, 294, 139-148
Alkaline elution has been used for quantitative detection of DNA damage caused by ionizing radiation in unlabeled somatic and germ cells. Both the induction and subsequent repair have been studied for two classes of DNA damage, viz. single-strand bre
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