Zobrazeno 1 - 10
of 279
pro vyhledávání: '"G.P. Dutta"'
This book details antimalarial suppositories proposed for emergency life-saving treatment of children and adults suffering from severe and cerebral malaria. It stresses the importance of emergency antimalarial therapy to save the lives of patients wh
Autor:
Anil K. Saxena, Arif Jamal Siddiqui, Nitya Anand, Jyoti Bhardwaj, Mridula Saxena, Sunil K. Puri, G.P. Dutta, Chandra S. Azad
Publikováno v:
Chemical Biology & Drug Design. 90:254-261
Primaquine (PQ) is the only drug used to prevent relapse of malaria due to P. vivax and P. ovale, by eradicating the dormant liver form of the parasite (hypnozoites). The side-effects associated with PQ limits is uses in treatment of malaria. To over
Publikováno v:
Life Sciences. 67:759-763
Pyronaridine, administered intramuscularly (im) to Swiss mice infected with the lethal multidrug-resistant Plasmodium yoelii nigeriensis, was found to exert high blood schizontocidal activity. The efficacy of doses of pyronaridine ranging from 0.625
Publikováno v:
Molecular and Cellular Biochemistry. 194:179-183
Reactive oxygen species are important mediators of tissue injury during malaria infection. The status of hepatic oxidative stress and antioxidant defence indices were studied during Plasmodium yoelii nigeriensis (P. y. nigeriensis) infection and chlo
Publikováno v:
Journal of Interferon & Cytokine Research. 16:321-325
In vitro as well as in vivo studies suggest that cytokine-induced synthesis of nitric oxide (NO) from L-arginine is a major effector mechanism against intracellular pathogens. In this study, we demonstrate that golden hamsters infected with Leishmani
Autor:
G.P. Dutta, R.C. Srimal, Prati Pal Singh, V.C. Dhawan, K.B. Mathur, Dhawan Bn, Wahajul Haq, Savita J. Singh
Publikováno v:
Immunopharmacology. 27:245-251
Methionine-enkephalin (ME) and its synthetic congener Tyr-D-Ala-Gly-Me-Phe-Gly-NH.C3H7-iso (82/205), in a concentration-dependent biphasic manner modulated the concanavalin A (Con A)-stimulated phagocytosis-promoting (PP)-activity elaboration in the
Autor:
Anju Mehrotra, G.P. Dutta
Publikováno v:
Life Sciences. 54:1861-1868
P. cynomolgi B -rhesus monkey model of malarial infection has been used to study lipid infiltration in host tissues in early (exoerythrocytic) and late (chronic) stages of malaria infection. Histochemically we could demonstrate significant infiltrati
Publikováno v:
Life Sciences. 54:331-339
The effect of morphine on immunomodulation and host defense have been investigated during Plasmodiumbergheiinfection in BALB/c mice. A single low (5.0 mg/kg) subcutaneous dose of morphine strongly suppressed (sometimes completely eliminated) the para
Publikováno v:
International Journal for Parasitology. 23:231-234
Hepatic heme-oxygenase and heme levels were monitored during Plasmodium berghei infection and chloroquine treatment in Swiss albino mice. A progressive increase in heme-oxygenase and heme levels was noticed with the rise in parasitemia. Further, chlo
Publikováno v:
International Journal for Parasitology. 21:463-466
The hepatic microsomal mixed-function oxidase (MFO) system was markedly impaired during Plasmodium berghei infection in mice. Cytochrome P-450 and other mono-oxygenases, viz. aniline hydroxylase, aminopyrine- N -demethylase and benzo( a )pyrene hydro