Zobrazeno 1 - 10
of 44
pro vyhledávání: '"G.M.T. Vogel"'
Autor:
D.G. Meuleman, G.M.T. Vogel, Rienk Nieuwland, A. Sturk, Anita N. Böing, F.J. Hoek, M. N. Abid Hussein, E. Biro
Publikováno v:
Thrombosis research, 121(6), 865-871. Elsevier Limited
Introduction: Microparticles from activated endothelial cells (EMP) are well known to expose tissue factor (TF) and initiate coagulation in vitro. TF coagulant activity is critically dependent on the presence of aminophospholipids, such as phosphatid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a80054e44708b6a8c2859aaa8878bcd
https://doi.org/10.1016/j.thromres.2007.08.005
https://doi.org/10.1016/j.thromres.2007.08.005
Autor:
Martin-Jan Smit, Jac C. H. M. Wijkmans, Rong-Qiang Liu, Jaap van der Louw, Koc-Kan Ho, Jim Inglese, Shawn David Erickson, Ming You, Ellen Son, Andrew Laird Roughton, Douglas S. Auld, G.M.T. Vogel, Christopher M. Masterson, Paolo Conti, Daming Feng, Martijn Rooseboom, Adolph Bohnstedt, Celia Kingsbury, Maria L. Webb, Steven G. Kultgen, Yajing Rong, Michael Ohlmeyer, Philippe Samama, Wim Dokter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2724-2728
An imidazolylpyrimidine was identified in a CXCR2 chemokine receptor antagonist screen and was optimized for potency, in vitro metabolic stability, and oral bioavailability. It was found that subtle structural modification within the series affected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e77595dde5f19c6adc662437d25282
https://doi.org/10.1016/j.bmcl.2006.02.028
https://doi.org/10.1016/j.bmcl.2006.02.028
Autor:
Jan Kelder, Sjoerd F. van Aelst, Co A.M. Peters, Theo G. van Dinther, Peter D. J. Grootenhuis, A. Visser, Hans Lucas, Anton E.P. Adang, Johannes Bernardus Maria Rewinkel, D.G. Meuleman, Martin J. Smit, Adrianus Petrus Antonius De Man, G.M.T. Vogel, Constant A. A. van Boeckel
Publikováno v:
Journal of Medicinal Chemistry. 45:4419-4432
Despite intense research over the last 10 years, aided by the availability of X-ray structures of enzyme-inhibitor complexes, only very few truly orally active thrombin inhibitors have been found. We conducted a comprehensive study starting with pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b8dd5256b1dcd877b95198f2ee775e
https://doi.org/10.1021/jm011110z
https://doi.org/10.1021/jm011110z
Autor:
Ronald Gijsbertus Ma. Amsterdam, Marijke Tromp, Dirk G. Meuleman, Theo G. van Dinther, G.M.T. Vogel
Publikováno v:
Thrombosis and Haemostasis. 84:611-620
SummaryOrg 36764, is an antithrombin III (AT) and thrombin binding carbohydrate, which accelerates the inactivation of both factor Xa and thrombin by AT. It displays in buffer an anti-Xa and anti-thrombin activity of 415 and 2 U/mg, respectively, com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34de7bbad7ab1b71d41ca240637c177f
https://doi.org/10.1055/s-0037-1614076
https://doi.org/10.1055/s-0037-1614076
Autor:
P. Zandberg, W. J. Kop, R. G. M. Van Amsterdam, P. van Houwelingen, G.M.T. Vogel, D.G. Meuleman, F. W. J. Van Mensvoort
Publikováno v:
Thrombosis and Haemostasis. 77:183-189
SummaryTwo thrombosis models in rats are described in which mixed type thrombi are formed at arterial and venous flow rates. The models, containing a silk thread in the aorta and vena cava, respectively, were characterised for the activity of three p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14728923992324131ec0c09e6714a5fa
https://doi.org/10.1055/s-0038-1655928
https://doi.org/10.1055/s-0038-1655928
Autor:
R. G. M. Van Amsterdam, J.P. He´rault, G.M.T. Vogel, D.G. Meuleman, M. Petitou, J.C. Lormeau, A. Bernat, J.M. Herbert
Publikováno v:
Circulation Research. 79:590-600
SANORG 32701 is a new sulfated pentasaccharide obtained by total chemical synthesis. It is an analogue of the “synthetic pentasaccharide” (SR 90107/ORG 31540), which represents the antithrombin III (AT-III) binding site of heparin. Like SR 90107,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecbc9071b7c42a66f674a1806028129
https://doi.org/10.1161/01.res.79.3.590
https://doi.org/10.1161/01.res.79.3.590
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 15:495-503
Abstract The synthetic pentasaccharide Org 31540/SR 90107A represents the antithrombin III (ATIII) binding region of heparin and accelerates the ATIII-mediated inhibition of coagulation factor Xa. This compound and 15 structural analogues with ATIII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3993ae80b3a7cc1aa9cf42d3404474
https://doi.org/10.1161/01.atv.15.4.495
https://doi.org/10.1161/01.atv.15.4.495
Publikováno v:
Thrombosis and Haemostasis. 69:029-034
SummaryThe mode of action of glycosaminoglycans (GAGs) towards thrombus formation in a rat arteriovenous shunt was studied by simultaneous examination of thrombus weight, platelet consumption and thrombin generation during 45 min of blood circulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb87bcd8952e9e72630d6650b5f081a
https://doi.org/10.1055/s-0038-1651543
https://doi.org/10.1055/s-0038-1651543
Autor:
T. G. Van Dinther, H. C. T. Moelker, C. A. A. Van Boeckel, D.G. Meuleman, P.M.J. Hobbelen, G.M.T. Vogel
Publikováno v:
Thrombosis and Haemostasis. 63:265-270
SummaryThe antithrombotic and haemostatic effects of a pentasaccharide, the chemically synthesized antithrombin III (AT-III) binding fragment of heparin (PENTA), were investigated in rats in comparison with heparin. PENTA showed a dose-dependent anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dafa28c50c51bda1ad18b7ecfab24685
https://doi.org/10.1055/s-0038-1645206
https://doi.org/10.1055/s-0038-1645206
Publikováno v:
International journal of pharmaceutics. 263(1-2)
In this study the gastrointestinal absorption and P-glycoprotein (Pgp) efflux transport of heterocyclic drugs was investigated with the Caco-2 cell model. Based on the calculation of the physico-chemical properties a good oral absorption was predicte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e29368dcb4ab0a38d3a926dc62b4aef
https://pubmed.ncbi.nlm.nih.gov/12954186
https://pubmed.ncbi.nlm.nih.gov/12954186