Zobrazeno 1 - 10
of 61
pro vyhledávání: '"G.K. Poon"'
Autor:
G.K. Poon
Publikováno v:
Journal of Chromatography A. 794:63-74
The analysis of catechin and related polyphenolic compounds in crude tea extracts by direct infusing of the samples into the mass spectrometer is described in this report. The mass spectra of catechin and its analogues all produced strong deprotonate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ce93705619bf395bed4faacc5f68205
https://doi.org/10.1016/s0021-9673(97)01050-9
https://doi.org/10.1016/s0021-9673(97)01050-9
Autor:
Kenneth R. Harrap, G.K. Poon, A. Donaghue, Florence I. Raynaud, L.R. Kelland, Prakash Mistry, Barry A. Murrer, Christopher F. J. Barnard
Publikováno v:
Cancer Chemotherapy and Pharmacology. 38:155-162
This study evaluates the metabolic profile of JM216 [bis(acetato)ammine-dichloro(cyclohexylamine) platinum(IV)], the first orally administrable platinum complex, in plasma ultrafiltrates of 12 patients (n = 2-4 time points per patient) following diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de713d95e5429c6f6d80ec7fff595f8
https://doi.org/10.1007/s002800050464
https://doi.org/10.1007/s002800050464
Autor:
Ian R. Hardcastle, David H. Phillips, G.K. Poon, Kathleen J. Cole, Paul L. Carmichael, Alastair J. Strain, Adrian Keogh, Alan Hewer
Publikováno v:
Carcinogenesis. 17:89-94
The metabolic activation of tamoxifen and its metabolite alpha-hydroxytamoxifen in primary cultures of rat, mouse and human hepatocytes has been compared. The extent of formation of DNA adducts in these cells was measured by 32P-postlabelling, using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563283baa7397215c9f75c644d319b7c
https://doi.org/10.1093/carcin/17.1.89
https://doi.org/10.1093/carcin/17.1.89
Autor:
Kenneth R. Harrap, Florence I. Raynaud, Prakash Mistry, Lloyd R. Kelland, Barry A. Murrer, D. Odell, G.K. Poon, Christopher F. J. Barnard
Publikováno v:
Journal of Chromatography A. 712:61-66
Bis(acetato)amminedichloro(cyclohexylamine) platinum(IV) (JM216) is a new orally administered platinum complex with antitumor properties, and is currently undergoing phase II clinical trials. When JM216 was incubated with human plasma ultrafiltrate,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d00986d789237624c50ca6d6e59b4a1
https://doi.org/10.1016/0021-9673(95)00288-x
https://doi.org/10.1016/0021-9673(95)00288-x
Publikováno v:
Journal of Chromatography A. 628:215-233
Cyanobacterial neurotoxins such as anatoxin-a and saxitoxin, peptide hepatotoxins including microcystin variants and nodularin were studied by electrospray ionization-mass spectrometry following direct infusion of samples into the mass spectrometer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b79de3d6192eaf70729c4ada6c5a6f3
https://doi.org/10.1016/0021-9673(93)80005-s
https://doi.org/10.1016/0021-9673(93)80005-s
Autor:
R. McCague, Wilfried M. A. Niessen, C. E. M. Heeremans, R.A.M. van der Hoeven, J. van der Greef, G.K. Poon, M. Jarman, J.H. Davies
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 576:235-244
Liquid chromatography with thermospray mass spectrometry has proved to be an invaluable technique for the study of metabolic degradation of xenobiotics in complex biological fluids. This paper describes the detection of 4-hydroxyandrost-4-ene-3,17-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec93241658f062a55a835723b8803e2
https://doi.org/10.1016/0378-4347(92)80197-x
https://doi.org/10.1016/0378-4347(92)80197-x
Autor:
G.K. Poon, Michael Jarman, John Houghton, Martin G. Rowlands, J. H. Davies, Mitch Dowsett, R. J. Shearer
Publikováno v:
Journal of Enzyme Inhibition. 6:141-147
The steroidal aromatase inhibitor, 4-hydroxyandrost-4-ene-3,17-dione (4OHA) and its metabolites, 4-hydroxytestosterone (4OHT), 3 beta,17-dihydroxy-5 alpha-androstan-4-one (metabolite A) and 3 alpha, 17-dihydroxy-5 beta-androstan-4-one (metabolite B)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ff109bc22b4a66103d2c03b0cdb2b7
https://doi.org/10.3109/14756369209040745
https://doi.org/10.3109/14756369209040745
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 572:143-157
The identification of metabolites from the pyridylglutarimide 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (PG, Rogletimide) was achieved using liquid chromatography-mass spectrometry with a thermospray interface (LC-TSP-MS). The urinary metabolites inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa7b483640e1e32f02c33b54a53a975
https://doi.org/10.1016/0378-4347(91)80479-v
https://doi.org/10.1016/0378-4347(91)80479-v
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 565:75-88
A sensitive procedure for studying the metabolism of the steroidal aromatase inhibitor 4-hydroxyandrost-4-ene-3,17-dione (4OHA) was developed based on enzyme hydrolysis, liquid—liquid extraction and reversed-phase liquid chromatography coupled with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c78d71754c1d0111ed4ac8fcb4acbe
https://doi.org/10.1016/0378-4347(91)80372-j
https://doi.org/10.1016/0378-4347(91)80372-j
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 23(4)
Microcystins are a group of structurally similar cyclic heptapeptide hepatotoxins and tumor promoters, produced by cyanobacteria. A microbore liquid chromatography electrospray ionization ion-trap mass spectrometry (LC-ESI-ITMS) method has been devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8720f1f8eb2bdc101fcfff455210cc97
https://pubmed.ncbi.nlm.nih.gov/10975248
https://pubmed.ncbi.nlm.nih.gov/10975248