Výsledky vyhledávání - "G.J.M. Pruijn"

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Rapid lupus autoantigen relocalization and reactive oxygen species accumulation following ultraviolet irradiation of human keratinocytes

Autor: S Denniss, W. J. Van Venrooij, Karl E. Herbert, Joseph Lunec, D Chauhan, G.J.M. Pruijn, W. Lawley, A Doherty

Publikováno v: Rheumatology, 39, 253-61
Rheumatology, 39, 3, pp. 253-61

Objective. In vitro treatment with ultraviolet B ( UVB) induces relocalization of lupus autoantigens to the cell surface. We have addressed the relationship between autoantigen relocalization, accumulation of intracellular reactive oxygen species (RO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba0fb351d86a11164f7f11b96679d15
https://doi.org/10.1093/rheumatology/39.3.253

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The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis

Autor: Paul J. Utz, A.G. Van Der Heijden, S.A. Rutjes, W. J. Van Venrooij, G.J.M. Pruijn, C.H. Broekhuis

Publikováno v: Cell Death and Differentiation, 6, 976-86
Cell Death and Differentiation, 6, 10, pp. 976-86

Contains fulltext : 186150.pdf (Publisher’s version ) (Closed access) In the past few years, a role for apoptotic processes in the development of autoimmune diseases has been suggested. An increasing number of cellular proteins, which are modified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1061be2e88d6ca740d1033fd33971e24
https://doi.org/10.1038/sj.cdd.4400571

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Characterization of an anti-RNA recombinant autoantibody fragment (scFv) isolated from a phage display library and detailed analysis of its binding site on U1 snRNA

Autor: M.H.W. Stassen, G.J.M. Pruijn, Rene Hoet, S.W.M. Teunissen, W. J. Van Venrooij

Publikováno v: RNA. 4:1124-1133

This is the first study in which the complex of a monoclonal autoantibody fragment and its target, stem loop II of U1 snRNA, was investigated with enzymatic and chemical probing. A phage display antibody library derived from bone marrow cells of an S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb2eace7cc26d1009257ed7ba826871
https://doi.org/10.1017/s1355838298980633

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Accessibility of Epitopes on the 52-kD Ro/SSA Protein (Ro52) and on the RoRNP Associated Ro52 Protein as Determined by Anti-Peptide Antibodies

Autor: José Thijssen, V. Ricchiuti, W. J. Van Venrooij, Sylviane Muller, G.J.M. Pruijn

Publikováno v: Journal of Autoimmunity, 10, 2, pp. 181-191
Journal of Autoimmunity, 10, 181-191. Academic press ltd

The Ro ribonucleoprotein particle (RoRNP) is the target of a variety of specific anti-protein autoantibodies produced by patients with systemic autoimmune diseases. RoRNPs, the function of which remains elusive, appear to be rather heterogeneous in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06d3793bfb8306dee1190f5dc4f690c
https://doi.org/10.1006/jaut.1996.0122

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Interaction of the La (SS-B) Autoantigen with Small Ribosomal Subunits

Autor: G.J.M. Pruijn, Ron Peek, W. J. Van Venrooij

Publikováno v: European Journal of Biochemistry, 236, 649-655. Springer verlag
European Journal of Biochemistry, 236, 2, pp. 649-655

The La (SS-B) autoantigen is an evolutionarily conserved 47-kDa protein which binds to nascent RNA polymerase III transcripts and to a number of viral leader RNAs. The La protein plays a direct role in the termination of RNA polymerase III transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e3d8b3e46ac5990c30798a2a0978f8
https://doi.org/10.1111/j.1432-1033.1996.0649d.x

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Characterization of murine monoclonal antibodies against 60-kD Ro/SS-A and La/SS-B autoantigens

Autor: C.H.A. Veldhoven, A. W. C. M. Van Der Kemp, J. P. H. Thijssen, Ruud J.T. Smeenk, W. J. Van Venrooij, J. F. Meilof, G.J.M. Pruijn

Publikováno v: Clinical and Experimental Immunology. 101:45-54

SUMMARYSmall cytoplasmic ribonucleoproteins (scRNPs) are important autoantigens in patients with systemic lupus erythematosus and Sjögren's syndrome. MoAbs against these proteins were made by immunization of BALB/c mice with purified human recombina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340c977266bf2e5b27902897660d9274
https://doi.org/10.1111/j.1365-2249.1995.tb02275.x

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