Zobrazeno 1 - 10
of 46
pro vyhledávání: '"G.J. Ikeda"'
Publikováno v:
Food and Chemical Toxicology. 36:907-914
Uniformly 14C-ring-labelled tert-butylhydroquinone (TBHQ) was diluted with non-radioactive TBHQ and administered orally (for excretion studies) to Fischer 344 rats. An average of 72.9% and 10.6% of the administered radioactivity was recovered in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8677d197f7a3da713ebeccd5148f8228
https://doi.org/10.1016/s0278-6915(98)00075-1
https://doi.org/10.1016/s0278-6915(98)00075-1
Autor:
P.P. Sapienza, G.J. Ikeda
Publikováno v:
Food and Chemical Toxicology. 33:409-421
Tissue distribution, excretion and metabolism studies of pentachloroanisole (PCA), an environmental metabolite of pentachlorophenol (PCP), were conducted in the beagle dog and miniature pig following single oral doses (25 mg/kg) of radiolabelled PCA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7cfab9a1af866c0b002d3fbe7487c1
https://doi.org/10.1016/0278-6915(95)00001-i
https://doi.org/10.1016/0278-6915(95)00001-i
Publikováno v:
Food and Chemical Toxicology. 32:1137-1146
Male Sprague-Dawley rats and New Zealand White rabbits were administered 14C-labelled pentachloroanisole (PCA) in corn oil by gavage as single doses of 25 mg/kg and were then placed in individual metabolism cages for as long as 4 days. Peak blood lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc0b920e7892d0fb0c44b9b3fa52fad
https://doi.org/10.1016/0278-6915(94)90129-5
https://doi.org/10.1016/0278-6915(94)90129-5
Publikováno v:
Journal of AOAC INTERNATIONAL. 74:857-861
The homogeneity of test substances in a carrier (animal feed) is a critical factor In conducting long-term feeding studies in laboratory animals. A method for determining the adequate amount of mixing to achieve homogeneity by a mixer of the type des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90aa825b919723cd02564c440c439ddc
https://doi.org/10.1093/jaoac/74.5.857
https://doi.org/10.1093/jaoac/74.5.857
Publikováno v:
Food and Chemical Toxicology. 28:333-338
Male beagle dogs and miniature swine were given 14C-labelled 8-methoxypsoralen (8-MOP) as a single oral dose (10 mg/kg body weight). In dogs, there appeared to be wide variability in 8-MOP absorption as indicated by the broad range of percentages of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae337b672a16863e0a4bb363b66b6343
https://doi.org/10.1016/0278-6915(90)90107-x
https://doi.org/10.1016/0278-6915(90)90107-x
Autor:
Leonard Friedman, Dennis W. Gaines, Vira L. Olivito, Curtis N. Barton, Philip P. Sapienza, G.J. Ikeda, Theodore C. Michel, M.W. O'Donnell
Publikováno v:
Advances in Swine in Biomedical Research ISBN: 9781461376996
The Yucatan miniature pig was introduced to FDA’s Beltsville Research Facility in the early 1980s. We were impressed by the docile, calm temperament of this strain of miniature pig. The existing strain of miniature pig at our facility was a cross b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48ef790b5af36690e7147d9a4a5f960
https://doi.org/10.1007/978-1-4615-5885-9_10
https://doi.org/10.1007/978-1-4615-5885-9_10
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 31(4)
14 C-labelled cinnamic aldehyde (CNMA) was given as a single oral dose, or 24 hr after multiple oral administration of non-radioactive CNMA for 7 days at 24-hr intervals, to male Fischer 344 rats at dose levels of 5, 50 or 500 mg/kg body weight. Resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef13e661075d22e11d34fcbb5b47dd2
https://pubmed.ncbi.nlm.nih.gov/8477915
https://pubmed.ncbi.nlm.nih.gov/8477915
Autor:
Thomas F.X. Collins, John J. Walsh, Marcy L. McGinnis, Lois E. Bragg, Philip P. Sapienza, G.J. Ikeda
Publikováno v:
Journal of Applied Toxicology. 2:307-314
Pregnant FDA-strain Osborne-Mendel rats were administered repeated doses of caffeine by oral intubation (gavage) and by administration in the drinking water (ad libitum sipping). When [1-methyl-14C]caffeine was administered at a dosage of 80 mg per k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20635707e089fd2a39d688897a7fc139
https://doi.org/10.1002/jat.2550020609
https://doi.org/10.1002/jat.2550020609
Autor:
Charles R Warner, Nicholas C Adamo, Gracia A Perfetti, Eugene M Sporn, Eugene Miller, Mark T King, G.J. Ikeda
Publikováno v:
Journal of AOAC INTERNATIONAL. 65:275-277
FD&C Red No. 3 was mixed with 20 kg pig feed to give a concentration of 0.1%. A mixing time of 30 min was sufficient to achieve homogeneity for this mixture. For larger amounts or more flocculent types of additives, a longer time may be required. Amm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca1ffb45c64d70d798832f180a9ec341
https://doi.org/10.1093/jaoac/65.2.275
https://doi.org/10.1093/jaoac/65.2.275
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 23(6)
[N-Me-14C]Betaine was administered iv as a single dose (5 mg/kg) to pregnant beagle dogs and miniature pigs late in gestation. Two hr after administration of the radiolabel, when the compound was in equilibrium, the dams were killed and the foetuses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe7c30d9ed68ada5649c78fb19e6392
https://pubmed.ncbi.nlm.nih.gov/4040106
https://pubmed.ncbi.nlm.nih.gov/4040106