Structure-based classification of tauopathies

Autor: Fuyuki Kametani, Ruben Vidal, Mike van Beers, Abhay Kotecha, H. Tanaka, Airi Tarutani, Tammaryn Lashley, Wenjuan Zhang, Yang Yang, Yang Shi, Benjamin Falcon, Takeshi Ikeuchi, Michel Goedert, Sjors H.W. Scheres, Holly J. Garringer, Bernardino Ghetti, Gabor G. Kovacs, Mari Yoshida, Masato Hasegawa, Akiyoshi Kakita, Alexey G. Murzin, Andrew C Robinson, David M. A. Mann, Tamas Revesz, Yuko Saito, G.I. Hallinan, Shigeo Murayama

Publikováno v: Nature
Shi, Y, Zhang, W, Yang, Y, Murzin, A G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H J, Vidal, R, Hallinan, G I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A C, Mann, D M A, Kovacs, G G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M & Scheres, S H W 2021, ' Structure-based classification of tauopathies ', Nature, vol. 598, no. 7880, pp. 359-363 . https://doi.org/10.1038/s41586-021-03911-7

Ordered assembly of the tau protein into filaments characterizes multiple neurodegenerative diseases, which are called tauopathies. We previously reported that by electron cryo-microscopy (cryo-EM), tau filament structures from Alzheimer’s disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df46db44639458e3f071db56fadf1871
https://doi.org/10.1038/s41586-021-03911-7

Age-Dependent Formation of TMEM106B Amyloid Filaments in Human Brain

Autor: Kazuko Hasegawa, Ruben Vidal, Abhay Kotecha, Kathy L. Newell, Masato Hasegawa, Yuko Saito, Melissa Huang, Bernardino Ghetti, Tammaryn Lashley, G.I. Hallinan, Airi Tarutani, Tamas Revesz, Shigeo Murayama, Michel Goedert, Sofia Lövestam, Holly J. Garringer, John C. van Swieten, Yang Yang, Manuel Schweighauser, Diana Arseni, Masayuki Miyazaki, Masaki Takao, Benjamin Falcon, Mari Yoshida, Gabor G. Kovacs, Sjors H.W. Scheres, Yang Shi, Alexey G. Murzin, Wenjuan Zhang

SummaryMany age-dependent neurodegenerative diseases, like Alzheimer’s and Parkinson’s, are characterised by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β (Aβ), α-synuclein and TDP-43 are the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fdce1da12c85094ec5e9c1872cde49c
https://doi.org/10.1101/2021.11.09.467923

Cryo-EM structures and functional characterization of homo- and heteropolymers of human ferritin variants

Autor: Chen Sun, Kunpeng Li, Ruben Vidal, Bernardino Ghetti, Wen Jiang, Barry B. Muhoberac, Jose Irimia-Dominguez, Holly J. Garringer, G.I. Hallinan

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)

The role of abnormal brain iron metabolism in neurodegenerative diseases is still insufficiently understood. Here, we investigate the molecular basis of the neurodegenerative disease hereditary ferritinopathy (HF), in which dysregulation of brain iro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a59db13b32c97faa3c7951b13b2eac2
http://europepmc.org/articles/PMC7692541

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