Výsledky vyhledávání - "G.H.P. Te Wierik"

A new generation starch product as excipient in pharmaceutical tablets

Autor: Jacob Bergsma, Anna Wilhelmina Arends-Scholte, Anko C. Eissens, G.H.P. Te Wierik, Gerad Klaas Bolhuis

Publikováno v: International Journal of Pharmaceutics. 157:181-187

This paper describes the general applicability of a new pregelatinized starch product in directly compressible controlled-release matrix systems. It was prepared by enzymatic degradation of potato starch followed by precipitation (retrogradation), fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f837d9eb8d1f0d700dd003565b47812
https://doi.org/10.1016/s0378-5173(97)00234-2

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A new generation of starch products as excipient in pharmaceutical tablets . II. High surface area retrograded pregelatinized potato starch products in sustained-release tablets

Autor: G.H.P. Te Wierik, Coenraad F. Lerk, Anko C. Eissens, Anna Wilhelmina Arends-Scholte, Jack Bergsma

Publikováno v: Journal of Controlled Release, 45(1), 25-33. Elsevier Bedrijfsinformatie b.v.

A new linear short-chain starch product was prepared by gelatinization of potato starch followed by enzymatic degradation, precipitation (retrogradation) and filtration. A high specific surface area was subsequently created by washing with ethanol or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c8e66085c77c89fdb82568a0ca5150
https://doi.org/10.1016/S0168-3659(96)01535-0

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Improvement of dissolution of poorly soluble drugs by solid deposition on a super disintegrant. II. The choice of super disintegrants and effect of granulation

Autor: K Zuurman, G.H.P. Te Wierik, Gerad Klaas Bolhuis

Publikováno v: European Journal of Pharmaceutical Sciences. 5:63-69

It is demonstrated that the dissolution from capsules and tablets of poorly soluble, hydrophobic drugs can be strongly improved by solid deposition of the drug upon hydrophilic, strongly swelling carriers like the super disintegrants sodium starch gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd86d5becbb92f4f89d5920d6d68c28e
https://doi.org/10.1016/s0928-0987(96)00256-4

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A new generation of starch products as excipient in pharmaceutical tablets. I. Preparation and binding properties of high surface area potato starch products

Autor: A.C. Eissens, Jacob Bergsma, T Boersma, Lerk Coenraad, Anna Wilhelmina Arends-Scholte, G.H.P. Te Wierik

Publikováno v: International Journal of Pharmaceutics. 134:27-36

A new pharmaceutical excipient with a high binding capacity was prepared from potato starch by enzymatic degradation, followed by suitable dehydration of the precipitated and filtered retrograded starch to produce high specific surface area products.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f94128b444299e2ac711935b267e7bc
https://doi.org/10.1016/0378-5173(95)04383-7

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Preparation, characterization and pharmaceutical application of linear dextrins: V. Study on the binding properties of amylodextrin, metastable amylodextrin and metastable amylose

Autor: Lerk Coenraad, A.C. Eissens, G.H.P. Te Wierik

Publikováno v: International Journal of Pharmaceutics. 102:81-90

Amylodextrin, metastable amylodextrins, Amylose V and metastable amylose were investigated on their dry binding properties. Amylose V showed poor binding properties. Both amylodextrin and metastable amylodextrin produced tablets showing crushing stre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56f4fef1d4001f1250acf085a122908b
https://doi.org/10.1016/0378-5173(94)90042-6

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Preparation, characterization and pharmaceutical application of linear dextrins: IV. Drug release from capsules and tablets containing amylodextrin

Autor: A.C. Eissens, G.H.P. Te Wierik, Lerk Coenraad

Publikováno v: International Journal of Pharmaceutics. 98:219-224

Linear dextrin (amylodextrin) and its soluble fraction were investigated for their suitability to enhance diazepam release from capsules and tablets. Drug release was analyzed in the USP XXI paddle apparatus and performed in phosphate buffer pH 6.8,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebe98ebb71ac9161c8a6cdbdb462dd16
https://doi.org/10.1016/0378-5173(93)90059-o

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