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pro vyhledávání: '"G.H. Constantine"'
Publikováno v:
SpringerPlus
The brine shrimp (Artemia salina) bioassay was used to screen 211 methanol extracts from 128 species of Pacific Northwest plants in search of general cytotoxic activity. Strong toxicity (LC50 1000 µg/ml). Our subsequent studies of conifer heartwoods
Autor:
G.H. Constantine, J. Karchesy
Publikováno v:
Pharmaceutical Biology. 36:365-367
Twelve samples of Hypericum perforatum L. (St. John’s wort) were collected throughout Oregon and assayed for hypericin concentrations which ranged from 0.03 to 0.38%. Eight commercially available dietary supplements were also assayed using the same
Publikováno v:
Fitoterapia. 72(5)
The isolation of (+)-totarol as active compound against Mycobacterium tuberculosis is reported from Chamaecyparis nootkatensis outerbark.
Publikováno v:
Toxicology and Applied Pharmacology. 54:399-404
Treatment of Yersinia ruckeri-infected juvenile coho salmon with tobramycin (TBM) revealed significant toxicity of the drug to these fish. In a group of fish receiving only 5 mg/kg/day a cumulative mortality of 100% was observed in 21 days. To verify
Publikováno v:
Aquaculture. 5:299-304
Selective solvent extracts prepared from 25 species of marine invertebrates collected in the waters of the Pacific Northwest were evaluated for antimicrobial activity. 52 instances of inhibition of microbial growth were observed, including 23 against
Publikováno v:
Marine Chemistry. 1:157-162
Choline sulfate (ester) was isolated from the marine imperfect fungus Zalerion maritimum (Linder) Anastasiou, and was subsequently revealed by comparative thin-layer chromatography in eighteen additional isolates of marine fungi including Z. maritimu
Publikováno v:
Journal of Pharmaceutical Sciences. 55:1378-1382
Improved methods of extraction and new techniques of isolation and identification of 11 components from the title plants were conducted. A solvent mixture of diverse polarity extracted four polycyclic compounds, a hydrocarbon, two flavonoids, and fou
Publikováno v:
Phytochemistry. 7:1379-1383
The underground portions of Vaccinium membranaceum (Dougl.) and V. parvifolium (Sm.) were examined for their triterpene content. The first-mentioned ericaceous plant yielded taraxerol, taraxerone, β-sitosterol, and friedel-3-ene. All but the last co
Autor:
J. H. Block, G.H. Constantine
Publikováno v:
Phytochemistry. 11:3279-3282
Updated NMR evidence is given that a previously reported triterpenoid oxide is not D:B Friedoolean-3,5-oxide, but is, instead, D:B-Friedoolean-3,10-oxide. A mechanistic explanation is given as to why the chemical evidence does not seem to support the
Autor:
G.H. Constantine
Publikováno v:
Phytochemistry. 9:1659-1665
The triterpenoid epoxide present in the title plant has been isolated previously from species of Dendropanax and other Rhododendrons and given different names, i.e. epoxyglutinane, dendropanoxide, and possibly campanulin. Previously conflicting evide