Zobrazeno 1 - 10
of 166
pro vyhledávání: '"G.E. Neal"'
Publikováno v:
Journal of Biological Chemistry. 269:20707-20717
Fetal rat liver possesses substantial levels of glutathione S-transferase (GST) activity toward aflatoxin B1-8,9-epoxide. The enzyme responsible for this activity is an Alpha-class GST heterodimer comprising Yc1 and Yc2 subunits. The cDNAs encoding t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4b2402a9230cb1d55a38029e6f0167
https://doi.org/10.1016/s0021-9258(17)32050-1
https://doi.org/10.1016/s0021-9258(17)32050-1
Publikováno v:
Toxicology and applied pharmacology. 125(1)
Rat hepatocytes on culturing rapidly lose the ability to metabolize many xenobiotics including the mycotoxin aflatoxin B1 (AFB1). Rat hepatocytes cultured for 5 days on plastic retain10% of the initial cytochrome P450 content compared with 34% in cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960207ab46134e6e2e8e8743ddfa6595
https://pubmed.ncbi.nlm.nih.gov/8128492
https://pubmed.ncbi.nlm.nih.gov/8128492
Publikováno v:
Carcinogenesis. 13(12)
Hepatocyte proliferation was analyzed in vivo during the time course of continuous administration to rats of the liver tumor promoter ethinyl estradiol (EE) at 10 p.p.m. in the diet. EE-induced acute liver hyperplasia was detected in male and female
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b517eca36c171e651437c706408cd4c0
https://pubmed.ncbi.nlm.nih.gov/1361882
https://pubmed.ncbi.nlm.nih.gov/1361882
Autor:
Z.S.C. Okoye, G.E. Neal
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 29(1)
In a previous study (Okoye and Neal, Food and Chemical Toxicology 1988, 26, 679) enhanced ethanol-induced reductions in albumin-bound and unbound serum aflatoxin B1 (AFB1) and increased hepatic DNA-AFB1 binding were observed in rats treated with bark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1cfdb1cf9997bd430dcd47df31101ad
https://pubmed.ncbi.nlm.nih.gov/1900252
https://pubmed.ncbi.nlm.nih.gov/1900252
Akademický článek
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Publikováno v:
Biochemical Pharmacology. 36:4269-4276
Glutathione-S-transferase (GST) activity has been examined in liver cytosol fractions from guinea pigs, mice, control fed rats or rats with pre-neoplastic nodular liver lesions. The levels of activity in unfractionated cytosols have been assayed usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2b80026357bab18f5247ef5c147665
https://doi.org/10.1016/0006-2952(87)90669-1
https://doi.org/10.1016/0006-2952(87)90669-1
Autor:
G.E. Neal, S.A. Metcalfe
Publikováno v:
Carcinogenesis. 4:1007-1012
Isolated rat hepatocytes, an intact cellular system capable of performing phase I and phase II metabolism, have been used to investigate metabolism of aflatoxin B1. These cells were found to metabolise (/sup 14/C)aflatoxin B1 to aflatoxins M1 and Q1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7103708234551f5a85883c3bb20eb6f
https://doi.org/10.1093/carcin/4.8.1007
https://doi.org/10.1093/carcin/4.8.1007
Autor:
G.E. Neal, J.R.P. Cabral
Publikováno v:
Tumori Journal. 69:195-199
The incidence of testicular mesotheliomas after exposure to the carcinogen N-2-fluorenylacetamide (FAA) was studied in Fischer 344 rats. The animals were fed a carcinogenic diet (containing 0.06 % FAA) for 4 weeks and then a control diet for 1 week.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac9f3832d45c16fe6ff6ea81c6cfe1b
https://doi.org/10.1177/030089168306900304
https://doi.org/10.1177/030089168306900304
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects. 68:68-77
The distribution of labelling among certain fractions prepared at intervals from yeast cells following an initial brief period of uptake of [14]arginine was consistent with the earlier idea that the amino acid entered protein via nucleotide-peptides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c57567bcefaa908cc40467aaecc1c6ee
https://doi.org/10.1016/0926-6550(63)90408-0
https://doi.org/10.1016/0926-6550(63)90408-0
Publikováno v:
Biochemical Pharmacology. 18:159-171
Rat liver tetrahydrofolate dehydrogenase activity in vivo recovers rapidly from inhibition by methotrexate, despite the known stability of the enzyme-inhibitor complex. Control levels of activity are usually regained within 24 hr following a single i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1cbc5aeec0ef8af8451a1cc53b24a3
https://doi.org/10.1016/0006-2952(69)90021-5
https://doi.org/10.1016/0006-2952(69)90021-5