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Publikováno v:
The Journal of Pathology. 187:433-438
Recent evidence associates the codon 12 valine-for-glycine (G12V) mutant Ki-Ras protein with higher stage and increased lethality of colorectal carcinomas, while the codon 12 aspartate-for-glycine (G12D) Ras mutation shows no such association. Severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::636d904d5f8315eefde8739896519349
https://doi.org/10.1002/(sici)1096-9896(199903)187:4<433::aid-path273>3.0.co
https://doi.org/10.1002/(sici)1096-9896(199903)187:4<433::aid-path273>3.0.co
Autor:
G.D. Birnie, Fahd Al-Mulla, Alison Winter, Ian R. Pickford, James J. Going, Evin T. H. H. Sowden
Publikováno v:
The Journal of Pathology. 185:130-138
The point mutations occurring in codons 12 and 13 of Ki-ras in 78 patients with colorectal carcinoma (31 Dukes' A and B, 21 Dukes' C, and 26 Dukes' D) have been determined by allele-specific oligonucleotide hybridization and sequencing. Duplicate sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9277e688e0a032a3847e855a903f2f3
https://doi.org/10.1002/(sici)1096-9896(199806)185:2<130::aid-path85>3.0.co
https://doi.org/10.1002/(sici)1096-9896(199806)185:2<130::aid-path85>3.0.co
Autor:
Kevin M. Ryan, G.D. Birnie
Publikováno v:
Biochemical Journal. 325:79-85
It has been shown that during myeloid differentiation the levels of mad1 mRNA are induced before the loss of c-Myc protein. This suggests that inactivation of the differentiation-blocking activity of c-Myc might not occur primarily through the loss o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44aba076303ddaf9345bab8f9e1f92ca
https://doi.org/10.1042/bj3250079
https://doi.org/10.1042/bj3250079
Autor:
Kevin M. Ryan, G.D. Birnie
Publikováno v:
Oncogene. 14:2835-2843
The c-myc proto-oncogene has been shown to cause blockages to differentiation in many cell lineages. Although the mechanism by which c-Myc affects this process remains unknown, it is considered that it might result indirectly as an outcome of the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d135825fa1406c9df9828c4d00224c3
https://doi.org/10.1038/sj.onc.1201124
https://doi.org/10.1038/sj.onc.1201124
Autor:
G.D. Birnie, Kevin M. Ryan
Publikováno v:
Biochemical Journal. 314:713-721
The myc family of proto-oncogenes is believed to be involved in the establishment of many types of human malignancy. The members of this family have been shown to function as transcription factors, and through a designated target sequence bring about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0204de810dc1a1125e95f19605be68
https://doi.org/10.1042/bj3140713
https://doi.org/10.1042/bj3140713
Publikováno v:
Differentiation. 45:49-54
Transcription of the c-myc gene is initiated mainly from two promoters, P1 and P2. By S1 nuclease analysis we found that there is 8 times more P2- than P1-initiated RNA in total RNA from HL60 cells. The half-lives of P1- and P2-initiated transcripts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7aaded97a28eb16a7fcf8e9f17b5f27
https://doi.org/10.1111/j.1432-0436.1990.tb00456.x
https://doi.org/10.1111/j.1432-0436.1990.tb00456.x
Publikováno v:
Cancer genetics and cytogenetics. 107(2)
The oncogenic activity of c-MYC is well known, and genetic aberrations in this locus are associated with a variety of human neoplasms. Because the encoded MYC protein has transcriptional activity only when dimerized with MAX, it is possible that muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6b95c986ada181771b9004d0f95dfc
https://pubmed.ncbi.nlm.nih.gov/9844600
https://pubmed.ncbi.nlm.nih.gov/9844600
Publikováno v:
Differentiation; research in biological diversity. 49(2)
Changes in the relative abundances of c-myc mRNA have been related to changes in other parameters of differentiation (histochemical, clonogenic) during the course of the differentiation of HL60 cells to monocytes/macrophages or to granulocytes. Induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f017fdc3e27f971666c4d00b83e6a5
https://pubmed.ncbi.nlm.nih.gov/1597257
https://pubmed.ncbi.nlm.nih.gov/1597257
Autor:
Ian Pickford, G.D. Birnie
Publikováno v:
The Lancet. 340:372-373
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00fba23f62e733d4d8c7dcd8bb6228f7
https://doi.org/10.1016/0140-6736(92)91447-g
https://doi.org/10.1016/0140-6736(92)91447-g