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Proton NMR study of peptides from myelin basic protein: evidence for Lys74-His77 interaction revealed from histidine line broadening

Autor: Joan M. Boggs, K.M. Koshy, G.A. Hashim

Publikováno v: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1293:23-30

Residues 69-84 of guinea pig myelin basic protein contain the encephalitogenic determinant for the Lewis rat. Insertion of histidine and glycine at positions 77 and 78 in bovine MBP greatly reduces the encephalitogenicity of the protein. Synthetic pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf4e6c0991257da2eac2a9c94862ceb
https://doi.org/10.1016/0167-4838(95)00229-4

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T cell receptor peptides in treatment of autoimmune disease: Rationale and potential

Autor: Halina Offner, Arthur A. Vandenbark, G.A. Hashim

Publikováno v: Journal of Neuroscience Research. 43:391-402

The natural tendency in T cell-mediated autoimmune conditions to develop focused antigen-specific responses that over-utilize certain T cell receptor (TCR) V region segments prompts the induction of anti-TCR-specific T cells and antibodies that can i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0d2b8e88e2e505941e4f5b89a565e77
https://doi.org/10.1002/(sici)1097-4547(19960215)43:4<391::aid-jnr1>3.0.co

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Natural immunodominant and experimental autoimmune encephalomyelitis-protective determinants within the lewis rat V?8.2 sequence include CDR2 and framework 3 idiotopes

Autor: Arthur A. Vandenbark, Halina Offner, B. Celnik, M. Vainiene, G.A. Hashim

Publikováno v: Journal of Neuroscience Research. 43:137-145

The V beta 8.2-39-59 peptide has served as a prototypic natural regulatory idiotope in Lewis rats developing experimental autoimmune encephalomyelitis (EAE). The purpose of the present study was to determine if additional regulatory regions were cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cb3b2a94a7aeeb4ec5672609502cd14
https://doi.org/10.1002/(sici)1097-4547(19960115)43:2<137::aid-jnr2>3.0.co

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T cell receptor V? gene usage in the recognition of myelin basic protein by cerebrospinal fluid- and blood-derived T cells from patients with multiple sclerosis

Autor: William J. Morrison, J. Atherton, Dennis Bourdette, J. Lane, Ruth H. Whitham, R. Dedrick, G.A. Hashim, Halina Offner, Arthur A. Vandenbark, E. Spoor, A. C. Burenafe, Yuan K. Chou

Publikováno v: Journal of Neuroscience Research. 37:169-181

Because of its proximity to the central nervous system, the cerebrospinal fluid (CSF) represents an important source of T cells that potentially could mediate putative autoimmune diseases such as multiple sclerosis (MS). To overcome the low CSF cellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467e6eb427878ae9f0edee966e475b72
https://doi.org/10.1002/jnr.490370203

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Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia

Autor: Jack M. Gorman, David H. Strauss, K. Kilidireas, A.D. Gorig, Norman Latov, Saud Sadiq, G.A. Hashim

Publikováno v: The Lancet. 340:569-572

Immune mechanisms are thought to be important in a subpopulation of patients with schizophrenia. We examined the specificity of neural antibodies in patients with schizophrenia to identify a possible antigen. Serum antibodies from patients with schiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e707fc8bd5853f6ff5748f338e6fe42
https://doi.org/10.1016/0140-6736(92)92105-o

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Adoptive transfer of experimental allergic encephalomyelitis and localization of the encephalitogenic epitope in the SWR mouse

Autor: Cedric S. Raine, Anne H. Cross, G.A. Hashim

Publikováno v: Journal of Neuroimmunology. 31:59-66

Adoptively-transferred experimental allergic encephalomyelitis (EAE) was induced in the SWR (H-2q) strain of mouse using lymph node cells, spleen cells, or cell lines sensitized to whole myelin basic protein (MBP). With the aid of synthetic peptides,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a0a738787a736ed3858bff73de1c5a
https://doi.org/10.1016/0165-5728(91)90087-n

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Studies on T-cell receptors involved in experimental autoimmune encephalomyelitis using the complementary peptide recognition approach

Autor: Arthur A. Vandenbark, G.A. Hashim, P. R. Carnegie, Cory J. Xian, D. O. Willenborg, R. D. Simmons

Publikováno v: Journal of neuroscience research. 41(5)

Based upon Blalock's complementary recognition approach, a complementary or antisense peptide (CP) was designed to the experimental autoiramune encephalomyelitis (EAE) epitope peptide, rat myelin basic protein (MBP) peptide 72-82. This peptide (EAE C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58f882bf890a43be30b03b850e39cfd
https://pubmed.ncbi.nlm.nih.gov/7563242

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